Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2017 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2017 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Efficacy of arsenic trioxide drug‑eluting stents in the treatment of coronary heart disease

  • Authors:
    • Shasha Zhang
    • Yuping Zhang
    • Shichuan Li
    • Zhifeng Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, P.R. China
  • Pages: 1634-1636
    |
    Published online on: February 7, 2017
       https://doi.org/10.3892/etm.2017.4106
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the current study was to evaluate the safety and clinical efficacy of arsenic trioxide drug‑eluting (AVI) stents, manufactured in China, for the treatment of coronary heart disease (CHD). Between January and August 2014, 40 patients with CHD admitted to Yongchuan Hospital with implanted AVI stents alone were selected. A one‑year clinical follow‑up was completed and one year postoperative coronary angiography was reviewed. Major adverse cardiovascular events (MACE), recurrent angina, stent restenosis and stent thrombosis cases were detected. All 40 patients with CHD completed the one‑year clinical follow‑up, as well as the one‑year postoperative coronary angiography. The follow‑up results indicated that the MACE rate was 15.0% (6/40), the target lesion revascularization rate was 15.0% (6/40), the angina recurrence rate was 32.5% (13/40), the in‑stent restenosis rate was 20.0% (8/40) and the stent thrombosis rate was zero. There were no cases of cardiac death or nonfatal myocardial infarction. The incidence of restenosis was higher following implantation of the AVI stent and the safety and clinical efficacy were worse than expected.
View Figures
View References

1 

Chang H, Wang Q, Shi T, Huo K, Li C, Zhang Q, Wang G, Wang Y, Tang B, Wang W, et al: Effect of DanQi Pill on PPARα, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease. BMC Complement Altern Med. 16:1032016. View Article : Google Scholar : PubMed/NCBI

2 

Lee VW, Cheng FW, Choi AY, Fong ST, Yu CM and Yan BP: Clinical, humanistic, and economic outcomes between drug-eluting stent (DES) and bare metal stent (BMS): 18-month follow-up study. J Med Econ. 1–7, 31 Oct. 2016.(Epub ahead of print). View Article : Google Scholar

3 

Babapulle MN and Eisenberg MJ: Coated stents for the prevention of restenosis: Part I. Circulation. 106:2734–2740. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Fricker J: Drug-eluting stents: Flashy future or flash-in-the-pan? Drug Discov Today. 6:1135–1137. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Regar E, Sianos G and Serruys PW: Stent development and local drug delivery. Br Med Bull. 59:227–248. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Dilda PJ and Hogg PJ: Arsenical-based cancer drugs. Cancer Treat Rev. 33:542–564. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Chen GQ, Shi XG, Tang W, Xiong SM, Zhu J, Cai X, Han ZG, Ni JH, Shi GY, Jia PM, et al: Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood. 89:3345–3353. 1997.PubMed/NCBI

8 

Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, Shi JY, Zheng PZ, Yan H, Liu YF, et al: All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA. 101:5328–5335. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, Ferrara F, Fazi P, Cicconi L, Di Bona E, et al: Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 369:111–121. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Zhang X, Yang XR, Sun C, Hu B, Sun YF, Huang XW, Wang Z, He YF, Zeng HY, Qiu SJ, et al: Promyelocytic leukemia protein induces arsenic trioxide resistance through regulation of aldehyde dehydrogenase 3 family member A1 in hepatocellular carcinoma. Cancer Lett. 366:112–122. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Hoffman EA, Gizelska K, Mirowski M and Mielicki W: Arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro. Contemp Oncol (Pozn). 19:108–112. 2015.PubMed/NCBI

12 

Liu ZM, Tseng HY, Cheng YL, Yeh BW, Wu WJ and Huang HS: TG-interacting factor transcriptionally induced by AKT/FOXO3A is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis. Toxicol Appl Pharmacol. 285:41–50. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Yang W, Ge J, Liu H, Zhao K, Liu X, Qu X, Li W, Huang Y, Sun A and Zou Y: Arsenic trioxide eluting stent reduces neointima formation in a rabbit iliac artery injury model. Cardiovasc Res. 72:483–493. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Shen L, Gong F, Tian W, Li W, Zhang F, Qian J, Sun A, Zou Y, Yang W and Ge J: Anti-inflammatory effects of arsenic trioxide eluting stents in a porcine coronary model. Biomed Res Int. 2013:9379362013. View Article : Google Scholar : PubMed/NCBI

15 

Li JX, Shen YQ, Cai BZ, Zhao J, Bai X, Lu YJ and Li XQ: Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation. Mol Biol Rep. 37:1569–1576. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Seldinger SI: Catheter replacement of the needle in percutaneous arteriography. A new technique. Acta Radiol Suppl (Stockholm). 434:47–52. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Li J, Elrashidi MY, Flammer AJ, Lennon RJ, Bell MR, Holmes DR, Bresnahan JF, Rihal CS, Lerman LO and Lerman A: Long-term outcomes of fractional flow reserve-guided vs. angiography-guided percutaneous coronary intervention in contemporary practice. Eur Heart J. 34:1375–1383. 2013. View Article : Google Scholar : PubMed/NCBI

18 

The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. TIMI Study Group. N Engl J Med. 312:932–936. 1985. View Article : Google Scholar : PubMed/NCBI

19 

Byrne RA, Sarafoff N, Kastrati A and Schömig A: Drug-eluting stents in percutaneous coronary intervention: A benefit-risk assessment. Drug Saf. 32:749–770. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Shen L, Yang W, Yin JS, Liu XB, Wu YZ, Sun AJ, Qian JY and Ge JB: Nine-month angiographic and two-year clinical follow-up of novel biodegradable-polymer arsenic trioxide-elutin gstent versus durable-polymer sirolimus-eluting stent for coronary artery disease. Chin Med J (Engl). 128:768–773. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Zhang Y, Li S and Li Z: Efficacy of arsenic trioxide drug‑eluting stents in the treatment of coronary heart disease. Exp Ther Med 13: 1634-1636, 2017.
APA
Zhang, S., Zhang, Y., Li, S., & Li, Z. (2017). Efficacy of arsenic trioxide drug‑eluting stents in the treatment of coronary heart disease. Experimental and Therapeutic Medicine, 13, 1634-1636. https://doi.org/10.3892/etm.2017.4106
MLA
Zhang, S., Zhang, Y., Li, S., Li, Z."Efficacy of arsenic trioxide drug‑eluting stents in the treatment of coronary heart disease". Experimental and Therapeutic Medicine 13.4 (2017): 1634-1636.
Chicago
Zhang, S., Zhang, Y., Li, S., Li, Z."Efficacy of arsenic trioxide drug‑eluting stents in the treatment of coronary heart disease". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1634-1636. https://doi.org/10.3892/etm.2017.4106
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Zhang Y, Li S and Li Z: Efficacy of arsenic trioxide drug‑eluting stents in the treatment of coronary heart disease. Exp Ther Med 13: 1634-1636, 2017.
APA
Zhang, S., Zhang, Y., Li, S., & Li, Z. (2017). Efficacy of arsenic trioxide drug‑eluting stents in the treatment of coronary heart disease. Experimental and Therapeutic Medicine, 13, 1634-1636. https://doi.org/10.3892/etm.2017.4106
MLA
Zhang, S., Zhang, Y., Li, S., Li, Z."Efficacy of arsenic trioxide drug‑eluting stents in the treatment of coronary heart disease". Experimental and Therapeutic Medicine 13.4 (2017): 1634-1636.
Chicago
Zhang, S., Zhang, Y., Li, S., Li, Z."Efficacy of arsenic trioxide drug‑eluting stents in the treatment of coronary heart disease". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1634-1636. https://doi.org/10.3892/etm.2017.4106
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team