Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants

Song,Yu'e; Sun,Shuzhen; Yu,Yonghui; Li,Gang; Song,Jia; Zhang,Hong; Yan,Chunmei

doi:10.3892/etm.2017.4107

April-2017 Volume 13 Issue 4

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April-2017 Volume 13 Issue 4

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Article Open Access

Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants

Authors:
- Yu'e Song
- Shuzhen Sun
- Yonghui Yu
- Gang Li
- Jia Song
- Hong Zhang
- Chunmei Yan
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Affiliations: Department of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Neonatology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Pediatrics, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia 014010, P.R. China

Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1245-1248
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Published online on: February 7, 2017

https://doi.org/10.3892/etm.2017.4107
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Abstract

The aim of the present study was to analyze the diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) in renal injury in asphyxiated preterm infants. In total, 48 cases of asphyxiated preterm infants, 45 cases of premature infants and 45 cases of normal newborn infants were included in the study. Using ELISA we evaluated the level of urine NGAL, kidney injury molecule-1 (KIM‑1), cystatin C (Cys-C) and serum creatinine (Scr). We also calculated the estimated glomerular filtration rate (eGFR). Our results showed that NGAL, KIM-1 and Cys-C levels in the group of asphyxiant renal injury within 24 and 48 h were markedly higher than the other two groups (P<0.05), while changes in Scr and eGFR within 24 h were not significant (P>0.05). Scr level in renal injury group within 48 h was markedly elevated while the eGFR level was visibly reduced (P<0.05). According to analysis of receiver operating characteristic curve, area under curve for NGAL in the group of asphyxiant renal injury within 24 and 48 h was significantly higher than KIM-1 and Cys-C. Susceptibility and specificity were improved. In conclusion, diagnosis of renal injury in asphyxia neonates using NGAL was more efficient compared to other methods.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Diagnostic value of neutrophil gelatinase-associated lipocalin for renal injury in asphyxiated preterm infants

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