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Article

Association of white blood cell counts with left ventricular mass index in hypertensive patients undergoing anti‑hypertensive drug therapy

  • Authors:
    • Hongtao Shi
    • Hongxia Chu
    • Zhiyang Lv
    • Guanming Qi
    • Junjie Guo
    • Wei Fu
    • Xiaojing Wang
    • Xiangyu Guo
    • Junbo Ge
    • Chengqian Yin
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Cardiology, Yuhuangding Hospital, Qingdao Medical College, Qingdao University, Yantai, Shandong 264000, P.R. China, Department of Cardiology, Yichang Central People's Hospital, Institute of Cardiovascular Diseases, Three Gorges University, Yichang, Hubei 443003, P.R. China, Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China, Department of Cardiology, Gaoan People's Hospital, Gaoan, Jiangxi 330800, P.R. China, Department of Pharmacy, Capital Medical University, Beijing 100054, P.R. China, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, P.R. China
  • Pages: 1566-1571
    |
    Published online on: February 10, 2017
       https://doi.org/10.3892/etm.2017.4119
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Abstract

Although studies using animal models have demonstrated that nonhemodynamic factors, including inflammatory cells and cytokines, contribute to left ventricular hypertrophy (LVH), there is little clinical data to confirm this association. Therefore in the present study, levels of circulating specific types of leukocyte were measured to determine the association between white blood cells and left ventricular mass index (LVMI) in hypertensive patients undergoing anti‑hypertensive drug therapy. A total of 144 consecutive hypertensive patients taking anti‑hypertensive drug therapy were enrolled in the current study. Subjects were divided into two groups: Those with normal geometry and those with left LVH. Total white blood cells and differentiated subtypes (neutrophils, lymphocytes, monocytes) were counted, and left ventricular end‑diastolic diameter, left ventricular posterior wall thickness in diastole and inter‑ventricular septal wall thickness in diastole were all measured. Analysis revealed a significant correlation between LVMI and total white blood cell levels (P=0.013). The percentage of LVH in the highest tertile of WBC was increased compared with the middle tertile (P=0.008). Furthermore, a significant correlation between the highest tertile of neutrophil counts and LVH was observed (P=0.039). However, no significant associations between LVMI and monocyte or lymphocyte counts were detected. Therefore, the current study determined that increased total white blood cell and neutrophil subtype counts were associated with LVMI in hypertensive patients undergoing anti‑hypertensive drug therapy. They may provide convenient and useful markers for further risk appraisal of LVH caused by nonhemodynamic factors of hypertension.
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Copy and paste a formatted citation
Spandidos Publications style
Shi H, Chu H, Lv Z, Qi G, Guo J, Fu W, Wang X, Guo X, Ge J, Yin C, Yin C, et al: Association of white blood cell counts with left ventricular mass index in hypertensive patients undergoing anti‑hypertensive drug therapy. Exp Ther Med 13: 1566-1571, 2017.
APA
Shi, H., Chu, H., Lv, Z., Qi, G., Guo, J., Fu, W. ... Yin, C. (2017). Association of white blood cell counts with left ventricular mass index in hypertensive patients undergoing anti‑hypertensive drug therapy. Experimental and Therapeutic Medicine, 13, 1566-1571. https://doi.org/10.3892/etm.2017.4119
MLA
Shi, H., Chu, H., Lv, Z., Qi, G., Guo, J., Fu, W., Wang, X., Guo, X., Ge, J., Yin, C."Association of white blood cell counts with left ventricular mass index in hypertensive patients undergoing anti‑hypertensive drug therapy". Experimental and Therapeutic Medicine 13.4 (2017): 1566-1571.
Chicago
Shi, H., Chu, H., Lv, Z., Qi, G., Guo, J., Fu, W., Wang, X., Guo, X., Ge, J., Yin, C."Association of white blood cell counts with left ventricular mass index in hypertensive patients undergoing anti‑hypertensive drug therapy". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1566-1571. https://doi.org/10.3892/etm.2017.4119
Copy and paste a formatted citation
x
Spandidos Publications style
Shi H, Chu H, Lv Z, Qi G, Guo J, Fu W, Wang X, Guo X, Ge J, Yin C, Yin C, et al: Association of white blood cell counts with left ventricular mass index in hypertensive patients undergoing anti‑hypertensive drug therapy. Exp Ther Med 13: 1566-1571, 2017.
APA
Shi, H., Chu, H., Lv, Z., Qi, G., Guo, J., Fu, W. ... Yin, C. (2017). Association of white blood cell counts with left ventricular mass index in hypertensive patients undergoing anti‑hypertensive drug therapy. Experimental and Therapeutic Medicine, 13, 1566-1571. https://doi.org/10.3892/etm.2017.4119
MLA
Shi, H., Chu, H., Lv, Z., Qi, G., Guo, J., Fu, W., Wang, X., Guo, X., Ge, J., Yin, C."Association of white blood cell counts with left ventricular mass index in hypertensive patients undergoing anti‑hypertensive drug therapy". Experimental and Therapeutic Medicine 13.4 (2017): 1566-1571.
Chicago
Shi, H., Chu, H., Lv, Z., Qi, G., Guo, J., Fu, W., Wang, X., Guo, X., Ge, J., Yin, C."Association of white blood cell counts with left ventricular mass index in hypertensive patients undergoing anti‑hypertensive drug therapy". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1566-1571. https://doi.org/10.3892/etm.2017.4119
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