Open Access

Dysfunction of the thymus in mice with hypertension

  • Authors:
    • Xianliang Dai
    • Shuaibo Huang
    • Zhiqing He
    • Feng Wu
    • Ru Ding
    • Yihong Chen
    • Chun Liang
    • Zonggui Wu
  • View Affiliations

  • Published online on: February 15, 2017     https://doi.org/10.3892/etm.2017.4125
  • Pages: 1386-1392
  • Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of this study was to evaluate thymus function in mice with hypertension. A total of 60 C57BL/6J mice were randomized into control, sham surgery and two‑kidney, one‑clip groups (n=20 in each). At 4 or 8 weeks after surgery, mice were sacrificed, and blood, spleens, kidneys and thymuses were harvested. The results of reverse transcription-quantitative polymerase chain reaction analysis revealed that the mRNA levels of Forkhead box protein N1 (Foxn1) and autoimmune regulator (AIRE) in the thymus tissue of mice from the HTN group were significantly lower than those from the control group at 4 and 8 weeks (P<0.05). Foxn1 and AIRE expression was also reduced in the sham surgery group at 4 weeks after surgery, but had recovered 4 weeks later. Similar results were observed for the expression of signal‑joint T cell receptor excision circles and the percentages of T cell subsets. The present study indicates that impaired thymus function is associated with hypertension in mice, which suggests that thymus function may be a novel target for the treatment of patients with hypertension.
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April-2017
Volume 13 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Dai X, Huang S, He Z, Wu F, Ding R, Chen Y, Liang C and Wu Z: Dysfunction of the thymus in mice with hypertension. Exp Ther Med 13: 1386-1392, 2017
APA
Dai, X., Huang, S., He, Z., Wu, F., Ding, R., Chen, Y. ... Wu, Z. (2017). Dysfunction of the thymus in mice with hypertension. Experimental and Therapeutic Medicine, 13, 1386-1392. https://doi.org/10.3892/etm.2017.4125
MLA
Dai, X., Huang, S., He, Z., Wu, F., Ding, R., Chen, Y., Liang, C., Wu, Z."Dysfunction of the thymus in mice with hypertension". Experimental and Therapeutic Medicine 13.4 (2017): 1386-1392.
Chicago
Dai, X., Huang, S., He, Z., Wu, F., Ding, R., Chen, Y., Liang, C., Wu, Z."Dysfunction of the thymus in mice with hypertension". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1386-1392. https://doi.org/10.3892/etm.2017.4125