Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2017 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2017 Volume 13 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis

  • Authors:
    • Wenping Pan
    • Zhankui Wang
    • Feilong Tian
    • Mingxian Yan
    • Yan Lu
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology and Immunology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China, Department of Gastroenterology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China, Department of Acupuncture and Moxibustion, Shandong College of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China
  • Pages: 1637-1643
    |
    Published online on: February 21, 2017
       https://doi.org/10.3892/etm.2017.4139
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study compared the clinical effectiveness of electroacupuncture (EA), monotherapy and combination therapy involving the administration of EA and mosapride in diabetic patients with severe or mild symptoms suggestive of gastroparesis. A total of 56 patients with type 2 diabetes who had symptoms suggestive of gastroparesis for >3 months were divided into two groups according to the Gastroparesis Cardinal Symptom Index (GCSI) score, including 33 in the mild group (GCSI score <3.5) and 23 in the severe group (GCSI score ≥3.5). Initially, all patients received EA monotherapy for 14 days. An effective response was defined as a reduction of the overall baseline GCSI score by >25% after treatment. The non‑responding patients then received a combination treatment with EA and mosapride. Gastric emptying was assessed by the 13C‑octanoic acid breath test at the beginning and end of each treatment session. Two patients in the severe group dropped out of the study during the initial treatment session. The results revealed that 34 early-responding patients (30 from the mild group and 4 from the severe group) treated with EA monotherapy, and 20 non‑early‑responding patients receiving combination therapy with EA and mosapride showed clinically significant improvements. Analysis of data from the mild subgroup demonstrated that EA treatment specifically improved symptoms of nausea, vomiting, stomach fullness, excessive fullness and bloating. There was no statistically significant difference in the gastric half‑emptying time among patients prior to and after EA monotherapy. These preliminary results suggested that EA may be an option for improving mild symptoms in patients with diabetic gastroparesis, whereas combination therapy involving EA and pharmaceutics is required in patients with severe symptoms.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Maleki D, GR III Locke, Camilleri M, Zinsmeister AR, Yawn BP, Leibson C and LJ III Melton: Gastrointestinal tract symptoms among persons with diabetes mellitus in the community. Arch Intern Med. 160:2808–2816. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Bytzer P, Talley NJ, Leemon M, Young LJ, Jones MP and Horowitz M: Prevalence of gastrointestinal symptoms associated with diabetes mellitus: A population-based survey of 15,000 adults. Arch Intern Med. 161:1989–1996. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Camilleri M, Parkman HP, Shafi MA, Abell TL and Gerson L; American College of Gastroenterology, : Clinical guideline: Management of gastroparesis. Am J Gastroenterol. 108:18–37; quiz 38. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Chang CS, Ko CW, Wu CY and Chen GH: Effect of electrical stimulation on acupuncture points in diabetic patients with gastric dysrhythmia: A pilot study. Digestion. 64:184–190. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Wang L: Clinical observation on acupuncture treatment in 35 cases of diabetic gastroparesis. J Tradit Chin Med. 24:163–165. 2004.PubMed/NCBI

6 

Xu S, Hou X, Zha H, Gao Z, Zhang Y and Chen JD: Electroacupuncture accelerates solid gastric emptying and improves dyspeptic symptoms in patients with functional dyspepsia. Dig Dis Sci. 51:2154–2159. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Wang CP, Kao CH, Chen WK, Lo WY and Hsieh CL: A single-blinded, randomized pilot study evaluating effects of electroacupuncture in diabetic patients with symptoms suggestive of gastroparesis. J Altern Complement Med. 14:833–839. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Liu S, Peng S, Hou X, Ke M and Chen JD: Transcutaneous electroacupuncture improves dyspeptic symptoms and increases high frequency heart rate variability in patients with functional dyspepsia. Neurogastroenterol Motil. 20:1204–1211. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Lin X, Liang J, Ren J, Mu F, Zhang M and Chen JD: Electrical stimulation of acupuncture points enhances gastric myoelectrical activity in humans. Am J Gastroenterol. 92:1527–1530. 1997.PubMed/NCBI

10 

Ouyang H, Yin J, Wang Z, Pasricha PJ and Chen JD: Electroacupuncture accelerates gastric emptying in association with changes in vagal activity. Am J Physiol Gastrointest Liver Physiol. 282:G390–G396. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Gao X, Qiao Y, Jia B, Jing X, Cheng B, Wen L, Tan Q, Zhou Y, Zhu B and Qiao H: NMDA Receotor-Dependent synaptic activity in dorsal motor nucleus of vagus mediates the enhancement of gastric motility by stimulating ST36. Evid Based Complement Alternat Med. 2012:4384602012. View Article : Google Scholar : PubMed/NCBI

12 

Lee CH, Kim DK, Yook TH, Sasaki M and Kitamura N: Effectiveness of electroacupuncture at Zusanli(ST36) on the immunohistochemical density of enteroendocrine cells related to gastrointestinal function. J Acupunct Meridian Stud. 5:63–71. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Revicki DA, Rentz AM, Dubois D, Kahrilas P, Stanghellini V, Talley NJ and Tack J: Development and validation of a patient-assessed gastroparesis symptom severity measure: The Gastroparesis Cardinal Symptom Index. Aliment Pharmacol Ther. 18:141–150. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Revicki DA, Rentz AM, Dubois D, Kahrilas P, Stanghellini V, Talley NJ and Tack J: Gastroparesis Cardinal Symptom Index (GCSI): Development and validation of a patient reported assessment of severity of gastroparesis symptoms. Qual Life Res. 13:833–844. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Talley NJ: Diabetic gastropathy and prokinetics. Am J Gastroenterol. 98:264–271. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Mansi C, Mekga P and Savarino V: Gastric emptying evaluation by 13C-octanoic acid breath test. Diabetes Nutr Metab. 17:43–46. 2004.PubMed/NCBI

17 

Satta P Usai, Scarpa M, Oppia F and Loriga F: 13C-octanoic acid breath test in function and organic disease: Critical review of literature. Eur Rev Med Pharmacol Sci. 9 5 Suppl 1:S9–S13. 2005.

18 

Takahashi T: Mechanism of acupuncture on neuromodulation in the gut: A review. Neuromodulation. 14:8–12. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Takahashi T: Effect and mechanism of acupuncture on gastrointestinal diseases. Int Rev Neurobiol. 111:273–294. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Abraham TS, Chen ML and Ma SX: TRPV1 expression in acupuncture points: Response to electroacupuncture stimulation. J Chem Neuroanat. 41:129–136. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Wang SJ, Yang HY and Xu GS: Acupuncture alleviates colorectal hypersensitivity and correlates with the regulatory mechanism of TrpV1 and p-ERK. Evid Based Complement Alternat Med. 2012:4831232012. View Article : Google Scholar : PubMed/NCBI

22 

Schneider A, Steitberger K and Joos S: Acupunture treatment in gastrointestinal disease: A systematic review. World J Gastroenterol. 13:3417–3424. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Yin J and Chen JD: Gastrointestinal motility disorders and acupuncture. Auton Neurosci. 157:31–37. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Fukuta H, Koshita M, Nakamura E, Nakamura H, Yamada A, Kawase Y, Ishigami T, Kurono Y, Iino S and Suzuki H: Acupuncture modulates mechanical responses of smooth muscle produced by transmural nerve stimulation in gastric antrum of genetically hyperglycemic rats. J Smooth Muscle Res. 45:167–185. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Iwa M, Nakade Y, Pappas TN and Takahashi T: Electroacupuncture elicits dual effects: Stimulation of delayed gastric emptying and inhibition of accelerated colonic transit induced by restraint stress in rats. Dig Dis Sci. 51:1493–1500. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Tabosa A, Yamamura Y, Forno ER and Mello LE: A comparative study of the effects of electroacupuncture and moxibustion in the gastrointestinal motility of the rat. Dig Dis Sci. 49:602–610. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Lorena SL, Tinois E, Brunetto SQ, Camargo EE and Mesquita MA: Gastric emptying and intragastric distribution of a solid meal in functional dyspepsia: Influence of gender and anxiety. J Clin Gastroenterol. 38:230–236. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Stanghellini V, De Giorgio R, Barbara G, Cogliandro R, Tosetti C, De Ponti F and Corinaldesi R: Delayed gastric emptying in functional dyspepsia. Curr Treat Options Gastroenterol. 7:259–264. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Samsom M, Vermeijden JR, Smout AJ, Van Doorn E, Roelofs J, Van Dam PS, Martens EP, Eelkman-Rooda SJ and Van Berge-Henegouwen GP: Prevalence of delayed gastric emptying in diabetic patients and relationship to dyspeptic symptoms: A prospective study in unselected diabetic patients. Diabet Care. 26:3116–3122. 2003. View Article : Google Scholar

30 

Pasricha PJ, Colvin R, Yates K, Hasler WL, Abell TL, Unalp-Arida A, Nguyen L, Farrugia G, Koch KL, Parkman HP, et al: Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying. Clin Gastroenterol Hepatol. 9:567–576.e1-4. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Abell TL, McCallum RW, et al: Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology. 140:101–115. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Schneider A, Löwe B and Streitberger K: Perception of bodily sensation as a predictor of treatment response to acupuncture for postoperative nausea and vomiting prophylaxis. J Altern Complement Med. 11:119–125. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Lee A and Done ML: The use of nonpharmacologic techniques to prevent postoperative nausea and vomiting: A meta-analysis. Anesth Analg. 88:1362–1369. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Janssen P, Harris MS, Jones M, Masaoka T, Farré R, Törnblom H, Van Oudenhove L, Simrén M and Tack J: The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis. Am J Gastroenterol. 108:1382–1391. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pan W, Wang Z, Tian F, Yan M and Lu Y: Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis. Exp Ther Med 13: 1637-1643, 2017.
APA
Pan, W., Wang, Z., Tian, F., Yan, M., & Lu, Y. (2017). Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis. Experimental and Therapeutic Medicine, 13, 1637-1643. https://doi.org/10.3892/etm.2017.4139
MLA
Pan, W., Wang, Z., Tian, F., Yan, M., Lu, Y."Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis". Experimental and Therapeutic Medicine 13.4 (2017): 1637-1643.
Chicago
Pan, W., Wang, Z., Tian, F., Yan, M., Lu, Y."Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1637-1643. https://doi.org/10.3892/etm.2017.4139
Copy and paste a formatted citation
x
Spandidos Publications style
Pan W, Wang Z, Tian F, Yan M and Lu Y: Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis. Exp Ther Med 13: 1637-1643, 2017.
APA
Pan, W., Wang, Z., Tian, F., Yan, M., & Lu, Y. (2017). Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis. Experimental and Therapeutic Medicine, 13, 1637-1643. https://doi.org/10.3892/etm.2017.4139
MLA
Pan, W., Wang, Z., Tian, F., Yan, M., Lu, Y."Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis". Experimental and Therapeutic Medicine 13.4 (2017): 1637-1643.
Chicago
Pan, W., Wang, Z., Tian, F., Yan, M., Lu, Y."Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis". Experimental and Therapeutic Medicine 13, no. 4 (2017): 1637-1643. https://doi.org/10.3892/etm.2017.4139
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team