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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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June-2017 Volume 13 Issue 6

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Article Open Access

Clinical evaluation of CENP‑B and Scl‑70 autoantibodies in silicosis patients

  • Authors:
    • Suni Lee
    • Hiroaki Hayashi
    • Naoko Kumagai‑Takei
    • Hidenori Matsuzaki
    • Kei Yoshitome
    • Yasumitsu Nishimura
    • Kozo Uragami
    • Masayasu Kusaka
    • Shoko Yamamoto
    • Miho Ikeda
    • Tamayo Hatayama
    • Wataru Fujimoto
    • Takemi Otsuki

  • View Affiliations / Copyright

    Affiliations: Department of Hygiene, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan, Department of Dermatology, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan, Hinase Uragami Iin, Bizen, Okayama 701‑3204, Japan, Kusaka Hospital, Bizen, Okayama 705‑0021, Japan
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2616-2622
    |
    Published online on: April 12, 2017
       https://doi.org/10.3892/etm.2017.4331
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Abstract

Silicosis patients (SIL) suffer from respiratory disorders and dysregulation of autoimmunity. Frequent complications such as rheumatoid arthritis, systemic sclerosis (SSc) and vasculitis are known in SIL. Furthermore, we reported previously that some SIL exhibited better respiratory conditions in association with a worse immunological status. In this study, the clinical roles of anti‑CENP‑B and Scl‑70 autoantibodies in SIL were analyzed. The titer index (Log10) of anti‑CENP‑B autoantibody in SIL was higher than that of healthy volunteers (HV), and that of SSc was higher than those of HV and SIL. This titer index was positively correlated with an assumed immune status of 1 for HV, 2 for SIL, and 3 for SSc. Moreover, although factor analysis revealed that the titer index of the anti‑CENP‑B autoantibody formed the same factor with the anti‑Scl‑70 autoantibody, IgG value and age in SIL cases, another extracted factor indicated that the IgA value and anti‑Scl‑70 antibody were positively related, but anti‑CENP‑B showed an opposite pattern in the results of the factor analysis. These findings indicated that the titer index of anti‑CENP‑B autoantibody may be a biomarker for dysregulation in SIL cases. Future clinical follow‑up of SIL may therefore require both respiratory and immunological assessment.

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Copy and paste a formatted citation
Spandidos Publications style
Lee S, Hayashi H, Kumagai‑Takei N, Matsuzaki H, Yoshitome K, Nishimura Y, Uragami K, Kusaka M, Yamamoto S, Ikeda M, Ikeda M, et al: Clinical evaluation of CENP‑B and Scl‑70 autoantibodies in silicosis patients. Exp Ther Med 13: 2616-2622, 2017.
APA
Lee, S., Hayashi, H., Kumagai‑Takei, N., Matsuzaki, H., Yoshitome, K., Nishimura, Y. ... Otsuki, T. (2017). Clinical evaluation of CENP‑B and Scl‑70 autoantibodies in silicosis patients. Experimental and Therapeutic Medicine, 13, 2616-2622. https://doi.org/10.3892/etm.2017.4331
MLA
Lee, S., Hayashi, H., Kumagai‑Takei, N., Matsuzaki, H., Yoshitome, K., Nishimura, Y., Uragami, K., Kusaka, M., Yamamoto, S., Ikeda, M., Hatayama, T., Fujimoto, W., Otsuki, T."Clinical evaluation of CENP‑B and Scl‑70 autoantibodies in silicosis patients". Experimental and Therapeutic Medicine 13.6 (2017): 2616-2622.
Chicago
Lee, S., Hayashi, H., Kumagai‑Takei, N., Matsuzaki, H., Yoshitome, K., Nishimura, Y., Uragami, K., Kusaka, M., Yamamoto, S., Ikeda, M., Hatayama, T., Fujimoto, W., Otsuki, T."Clinical evaluation of CENP‑B and Scl‑70 autoantibodies in silicosis patients". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2616-2622. https://doi.org/10.3892/etm.2017.4331
Copy and paste a formatted citation
x
Spandidos Publications style
Lee S, Hayashi H, Kumagai‑Takei N, Matsuzaki H, Yoshitome K, Nishimura Y, Uragami K, Kusaka M, Yamamoto S, Ikeda M, Ikeda M, et al: Clinical evaluation of CENP‑B and Scl‑70 autoantibodies in silicosis patients. Exp Ther Med 13: 2616-2622, 2017.
APA
Lee, S., Hayashi, H., Kumagai‑Takei, N., Matsuzaki, H., Yoshitome, K., Nishimura, Y. ... Otsuki, T. (2017). Clinical evaluation of CENP‑B and Scl‑70 autoantibodies in silicosis patients. Experimental and Therapeutic Medicine, 13, 2616-2622. https://doi.org/10.3892/etm.2017.4331
MLA
Lee, S., Hayashi, H., Kumagai‑Takei, N., Matsuzaki, H., Yoshitome, K., Nishimura, Y., Uragami, K., Kusaka, M., Yamamoto, S., Ikeda, M., Hatayama, T., Fujimoto, W., Otsuki, T."Clinical evaluation of CENP‑B and Scl‑70 autoantibodies in silicosis patients". Experimental and Therapeutic Medicine 13.6 (2017): 2616-2622.
Chicago
Lee, S., Hayashi, H., Kumagai‑Takei, N., Matsuzaki, H., Yoshitome, K., Nishimura, Y., Uragami, K., Kusaka, M., Yamamoto, S., Ikeda, M., Hatayama, T., Fujimoto, W., Otsuki, T."Clinical evaluation of CENP‑B and Scl‑70 autoantibodies in silicosis patients". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2616-2622. https://doi.org/10.3892/etm.2017.4331
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