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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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June-2017 Volume 13 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Morphological and functional changes in bone marrow mesenchymal stem cells in rats with heart failure

  • Authors:
    • Xiuli Wang
    • Chunmei Li
    • Haibin Gong

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Xuzhou Central Hospital, Xuzhou Cardiovascular Disease Institute, Xuzhou, Jiangsu 221009, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2888-2892
    |
    Published online on: April 13, 2017
       https://doi.org/10.3892/etm.2017.4341
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Abstract

The changes in bone marrow-derived mesenchymal stem cells (BMSCs), in terms of cell morphology and protein expression in rats with heart failure, were studied. Pressure overload chronic heart failure rat model was induced with partial constriction of the abdominal aorta. BMSCs from the model and the sham operation groups were isolated and cultured (cell density, 108 cells/l), and supernatant was collected after 72 h. Enzyme-linked immunosorbent assay was used to measure HGF, IGF-1, PDGF, SCF, FGF and VEGF levels in the supernatant. Results showed that in the model group, the minimum cell diameter, the average cell area and the protein expression in single BMSCs were significantly less than those in the sham operation group. In the model group, SCF and PDGF levels were significantly lower than those in the sham operation group. VEGF concentration in the model group was significantly higher than that in the sham operation group. Compared with normal rats, the morphology of BMSCs in rats with heart failure changed considerably, the protein expression of a single cell and the ability to secrete cytokines decreased in a meaningful way.

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Li C and Gong H: Morphological and functional changes in bone marrow mesenchymal stem cells in rats with heart failure. Exp Ther Med 13: 2888-2892, 2017.
APA
Wang, X., Li, C., & Gong, H. (2017). Morphological and functional changes in bone marrow mesenchymal stem cells in rats with heart failure. Experimental and Therapeutic Medicine, 13, 2888-2892. https://doi.org/10.3892/etm.2017.4341
MLA
Wang, X., Li, C., Gong, H."Morphological and functional changes in bone marrow mesenchymal stem cells in rats with heart failure". Experimental and Therapeutic Medicine 13.6 (2017): 2888-2892.
Chicago
Wang, X., Li, C., Gong, H."Morphological and functional changes in bone marrow mesenchymal stem cells in rats with heart failure". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2888-2892. https://doi.org/10.3892/etm.2017.4341
Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Li C and Gong H: Morphological and functional changes in bone marrow mesenchymal stem cells in rats with heart failure. Exp Ther Med 13: 2888-2892, 2017.
APA
Wang, X., Li, C., & Gong, H. (2017). Morphological and functional changes in bone marrow mesenchymal stem cells in rats with heart failure. Experimental and Therapeutic Medicine, 13, 2888-2892. https://doi.org/10.3892/etm.2017.4341
MLA
Wang, X., Li, C., Gong, H."Morphological and functional changes in bone marrow mesenchymal stem cells in rats with heart failure". Experimental and Therapeutic Medicine 13.6 (2017): 2888-2892.
Chicago
Wang, X., Li, C., Gong, H."Morphological and functional changes in bone marrow mesenchymal stem cells in rats with heart failure". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2888-2892. https://doi.org/10.3892/etm.2017.4341
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