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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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June-2017 Volume 13 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6

  • Authors:
    • Feng Xue
    • Jiwei Yin
    • Lin Xu
    • Boqing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatopancreatobiliary Surgery, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, P.R. China
  • Pages: 2667-2674
    |
    Published online on: April 18, 2017
       https://doi.org/10.3892/etm.2017.4348
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Abstract

MicroRNAs serve a critical role in human hepatocellular carcinoma (HCC) progression. However, the exact role of microRNA-143 (miR-143) in HCC remains unclear. The current study investigates the molecular mechanism of miR‑143 in HCC. In cultured HepG2 and Bel7402 cell lines, miR‑143 levels were raised by lentivirus transduction. This significantly inhibited HCC progression in terms of cell invasion and proliferation in both HepG2 and Bel7402 cell lines (P<0.05). MiR‑143 also significantly decreased tumor implantation in vivo (P<0.05). Regulation of miR‑143 on its direct target, GATA‑binding factor 6 (GATA6), was investigated by multiple strategies, including dual‑luciferase assay, quantitative polymerase chain reaction and western blot analysis. The results indicated that miR‑143 was downregulated in both HCC cell lines and human tumors. GATA6 was identified as the downstream target of miR‑143 in HCC, and overexpressing GATA6 was able to counter the tumor‑suppressive effect of miR‑143 on HCC in HepG2 and Bel7402 cells by significantly increasing proliferation and invasion rates (P<0.05). Therefore, a novel epigenetic pathway was identified in which miR‑143 may suppress the malignancy of HCC by targeting GATA6.

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Copy and paste a formatted citation
Spandidos Publications style
Xue F, Yin J, Xu L and Wang B: MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6. Exp Ther Med 13: 2667-2674, 2017.
APA
Xue, F., Yin, J., Xu, L., & Wang, B. (2017). MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6. Experimental and Therapeutic Medicine, 13, 2667-2674. https://doi.org/10.3892/etm.2017.4348
MLA
Xue, F., Yin, J., Xu, L., Wang, B."MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6". Experimental and Therapeutic Medicine 13.6 (2017): 2667-2674.
Chicago
Xue, F., Yin, J., Xu, L., Wang, B."MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2667-2674. https://doi.org/10.3892/etm.2017.4348
Copy and paste a formatted citation
x
Spandidos Publications style
Xue F, Yin J, Xu L and Wang B: MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6. Exp Ther Med 13: 2667-2674, 2017.
APA
Xue, F., Yin, J., Xu, L., & Wang, B. (2017). MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6. Experimental and Therapeutic Medicine, 13, 2667-2674. https://doi.org/10.3892/etm.2017.4348
MLA
Xue, F., Yin, J., Xu, L., Wang, B."MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6". Experimental and Therapeutic Medicine 13.6 (2017): 2667-2674.
Chicago
Xue, F., Yin, J., Xu, L., Wang, B."MicroRNA-143 inhibits tumorigenesis in hepatocellular carcinoma by downregulating GATA6". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2667-2674. https://doi.org/10.3892/etm.2017.4348
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