Open Access

Microarray profiling of long non-coding RNAs associated with idiopathic pulmonary arterial hypertension

Retraction in: /10.3892/etm.2017.4355

  • Authors:
    • Bing Han
    • Peili Bu
    • Xiao Meng
    • Xiaoyang Hou
  • View Affiliations

  • Published online on: April 18, 2017     https://doi.org/10.3892/etm.2017.4355
  • Pages: 2657-2666
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Idiopathic pulmonary arterial hypertension (IPAH) is a fatal disease with a poor prognosis and the molecular pathways underlying the pathogenesis of IPAH are not fully understood. In the present study, the long non‑coding RNA (lncRNA) and mRNA expression profiles of lymphocytes obtained from 12 IPAH patients and 12 healthy controls were analyzed using Arraystar Human lncRNA Microarray v2.0, and their roles in the pathogenesis of IPAH were characterized using comprehensive bioinformatic tools. A total of 2,511 lncRNAs (2,004 upregulated and 507 downregulated) and 1,169 mRNAs (609 upregulated and 560 downregulated) were aberrantly expressed in IPAH patients with a fold‑change of >2.0. Gene ontology analysis indicated that the coexpressed lncRNAs and mRNAs were involved in the process of translation, while pathway analysis indicated that the coexpressed RNAs were enriched during the process of oxidative phosphorylation and in the ribosome. It was concluded that dysregulated lncRNAs are potentially associated with IPAH, and aberrant lncRNA expression in blood cells may serve as a diagnostic marker of IPAH.

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June-2017
Volume 13 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Han B, Bu P, Meng X and Hou X: Microarray profiling of long non-coding RNAs associated with idiopathic pulmonary arterial hypertension Retraction in /10.3892/etm.2017.4355 . Exp Ther Med 13: 2657-2666, 2017
APA
Han, B., Bu, P., Meng, X., & Hou, X. (2017). Microarray profiling of long non-coding RNAs associated with idiopathic pulmonary arterial hypertension Retraction in /10.3892/etm.2017.4355 . Experimental and Therapeutic Medicine, 13, 2657-2666. https://doi.org/10.3892/etm.2017.4355
MLA
Han, B., Bu, P., Meng, X., Hou, X."Microarray profiling of long non-coding RNAs associated with idiopathic pulmonary arterial hypertension Retraction in /10.3892/etm.2017.4355 ". Experimental and Therapeutic Medicine 13.6 (2017): 2657-2666.
Chicago
Han, B., Bu, P., Meng, X., Hou, X."Microarray profiling of long non-coding RNAs associated with idiopathic pulmonary arterial hypertension Retraction in /10.3892/etm.2017.4355 ". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2657-2666. https://doi.org/10.3892/etm.2017.4355