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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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June-2017 Volume 13 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article Open Access

Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data

  • Authors:
    • Kezhen Wang
    • Xinmin Wang
    • Hongzhu Lv
    • Chengzhi Cui
    • Jiyong Leng
    • Kai Xu
    • Guosong Yu
    • Jianwei Chen
    • Peiyu Cong

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Dalian Municipal Central Hospital Affiliated to Dalian Medical University, Dalian, Liaoning 116033, P.R. China, Dalian Medical University Graduate School, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3239-3248
    |
    Published online on: April 25, 2017
       https://doi.org/10.3892/etm.2017.4378
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Abstract

Intracranial aneurysm (IA) remains one of the most devastating neurological conditions. However, the pathophysiology of IA formation and rupture still remains unclear. The purpose of the present study was to identify the crucial microRNA (miRNA/miR) and genes involved in IAs and elucidate the mechanisms underlying the development of IAs. In the present study, novel miRNA regulation activities in IAs were investigated through the integration of public gene expression data of miRNA and mRNA using the Gene Expression Omnibus database, combined with bioinformatics prediction. A total of 15 differentially expressed miRNA and 1,447 differentially expressed mRNA between IAs and controls were identified. A number of miRNA-target gene pairs (770), whose expression levels were inversely correlated, were used to construct a regulatory network of miRNA-target genes in IAs. The biological functions and pathways of these target genes were revealed to be associated with IAs. Specific miRNA and genes, such as hsa‑let‑7f, hsa‑let‑7d, hsa‑miR‑7, RPS6KA3, TSC1 and IGF1 may possess key roles in the development of IAs. The integrated analysis in the present study may provide insights into the understanding of underlying molecular mechanisms of IAs and novel therapeutic targets.

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Copy and paste a formatted citation
Spandidos Publications style
Wang K, Wang X, Lv H, Cui C, Leng J, Xu K, Yu G, Chen J and Cong P: Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data. Exp Ther Med 13: 3239-3248, 2017.
APA
Wang, K., Wang, X., Lv, H., Cui, C., Leng, J., Xu, K. ... Cong, P. (2017). Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data. Experimental and Therapeutic Medicine, 13, 3239-3248. https://doi.org/10.3892/etm.2017.4378
MLA
Wang, K., Wang, X., Lv, H., Cui, C., Leng, J., Xu, K., Yu, G., Chen, J., Cong, P."Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data". Experimental and Therapeutic Medicine 13.6 (2017): 3239-3248.
Chicago
Wang, K., Wang, X., Lv, H., Cui, C., Leng, J., Xu, K., Yu, G., Chen, J., Cong, P."Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3239-3248. https://doi.org/10.3892/etm.2017.4378
Copy and paste a formatted citation
x
Spandidos Publications style
Wang K, Wang X, Lv H, Cui C, Leng J, Xu K, Yu G, Chen J and Cong P: Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data. Exp Ther Med 13: 3239-3248, 2017.
APA
Wang, K., Wang, X., Lv, H., Cui, C., Leng, J., Xu, K. ... Cong, P. (2017). Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data. Experimental and Therapeutic Medicine, 13, 3239-3248. https://doi.org/10.3892/etm.2017.4378
MLA
Wang, K., Wang, X., Lv, H., Cui, C., Leng, J., Xu, K., Yu, G., Chen, J., Cong, P."Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data". Experimental and Therapeutic Medicine 13.6 (2017): 3239-3248.
Chicago
Wang, K., Wang, X., Lv, H., Cui, C., Leng, J., Xu, K., Yu, G., Chen, J., Cong, P."Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3239-3248. https://doi.org/10.3892/etm.2017.4378
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