Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning

  • Authors:
    • Xiao‑Wei Liu
    • Tao Ma
    • Lu‑Lu Li
    • Bo Qu
    • Zhi Liu
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Biostatistics, School of Public Health, China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 79-86
    |
    Published online on: May 17, 2017
       https://doi.org/10.3892/etm.2017.4463
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the predictive values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and Acute Physiology and Chronic Health Evaluation (APACHE) II score in the prognosis of patients with acute PQ poisoning. A total of 194 patients with acute PQ poisoning, hospitalized between April 2012 and January 2014 at the First Affiliated Hospital of P.R. China Medical University (Shenyang, China), were selected and divided into survival and mortality groups. Logistic regression analysis, receiver operator characteristic (ROC) curve analysis and Kaplan‑Meier curve were applied to evaluate the values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and (APACHE) II score for predicting the prognosis of patients with acute PQ poisoning. Initial urine PQ concentration (C0), dose of poison, arterial blood lactate and APACHE II score of patients in the mortality group were significantly higher compared with the survival group (all P<0.05). Logistic regression analysis revealed that C0, dose of poison and arterial blood lactate correlated with mortality risk of acute PQ poisoning (all P<0.05). ROC curve analysis suggested that the areas under the curve (AUC) values of C0, dose of poison, arterial blood lactate and APACHE II score in predicting the mortality of patients within 28 days were 0.921, 0.887, 0.808 and 0.648, respectively. The AUC of C0 for predicting early and delayed mortality were 0.890 and 0.764, respectively. The AUC values of urine paraquat concentration the day after poisoning (Csec) and the rebound rate of urine paraquat concentration in predicting the mortality of patients within 28 days were 0.919 and 0.805, respectively. The 28‑day survival rate of patients with C0 ≤32.2 µg/ml (42/71; 59.2%) was significantly higher when compared with patients with C0 >32.2 µg/ml (38/123; 30.9%). These results suggest that the initial urine PQ concentration may be the optimal index for predicting the prognosis of patients with acute PQ poisoning. Additionally, dose of poison, arterial blood lactate, Csec and rebound rate also have referential significance.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Sun IO and Lee KY: Cyclophosphamide dose: How much is needed to win the war against paraquat poisoning? Korean J Intern Med. 28:410–412. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Liu XW, Ma T, Qu B, Ji Y and Liu Z: Prognostic value of initial arterial lactate level and lactate metabolic clearance rate in patients with acute paraquat poisoning. Am J Emerg Med. 31:1230–1235. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Wunnapuk K, Mohammed F, Gawarammana I, Liu X, Verbeeck RK, Buckley NA, Roberts MS and Musuamba FT: Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: A model based approach. Br J Clin Pharmacol. 78:855–866. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, Remião F, Bastos ML and Carvalho F: Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol. 38:13–71. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Wu B, Song B, Yang H, Huang B, Chi B, Guo Y and Liu H: Central nervous system damage due to acute paraquat poisoning: An experimental study with rat model. Neurotoxicology. 35:62–70. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Liu Z, Zhao H, Liu W, Li T, Wang Y and Zhao M: NLRP3 inflammasome activation is essential for paraquat-induced acute lung injury. Inflammation. 38:433–444. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ruan XL, Qiu JJ, Wu C, Huang T, Meng RB and Lai YQ: Magnetic single-walled carbon nanotubes-dispersive solid-phase extraction method combined with liquid chromatography-tandem mass spectrometry for the determination of paraquat in urine. J Chromatogr B Analyt Technol Biomed Life Sci. 965:85–90. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Yeo CD, Kim JW, Kim YO, Yoon SA, Kim KH and Kim YS: The role of pentraxin-3 as a prognostic biomarker in paraquat poisoning. Toxicol Lett. 212:157–160. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Lee Y, Lee JH, Seong AJ, Hong CK, Lee HJ, Shin DH and Hwang SY: Arterial lactate as a predictor of mortality in emergency department patients with paraquat intoxication. Clin Toxicol (Phila). 50:52–56. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Seok S, Kim YH, Gil HW, Song HY and Hong SY: The time between paraquat ingestion and a negative dithionite urine test in an independent risk factor for death and organ failure in acute paraquat intoxication. J Korean Med Sci. 27:993–998. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Gil HW, Kang MS, Yang JO, Lee EY and Hong SY: Association between plasma paraquat level and outcome of paraquat poisoning in 375 paraquat poisoning patients. Clin Toxicol (Phila). 46:515–518. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Hassanian-Moghaddam H, Amiri H, Zamani N, Rahimi M, Shadnia S and Taherkhani M: QT dispersion and prognostication of the outcome in acute cardiotoxicities: A comparison with SAPS II and APACHE II scoring systems. Cardiovasc Toxicol. 14:129–133. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL and Christie JD: Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med. 37:1670–1677. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Weil MH and Tang W: Clinical correlates of arterial lactate levels in STEMI patients. Crit Care. 15:1132011. View Article : Google Scholar : PubMed/NCBI

15 

Yang CJ, Lin JL, Lin-Tan DT, Weng CH, Hsu CW, Lee SY, Lee SH, Chang CM, Lin WR and Yen TH: Spectrum of toxic hepatitis following intentional paraquat ingestion: Analysis of 187 cases. Liver Int. 32:1400–1406. 2012. View Article : Google Scholar : PubMed/NCBI

16 

M PN: World Medical Association publishes the Revised Declaration of Helsinki. Natl Med J India. 27:562014.PubMed/NCBI

17 

Berry DJ and Grove J: The determination of paraquat (I,I'-dimethyl-4,4′-bipyridylium cation) in urine. Clin Chim Acta. 34:5–11. 1971. View Article : Google Scholar : PubMed/NCBI

18 

Liu Z, Liu D, Zhang X, Wang H and Hao F: Prognosis value of urine paraquat semi-quantitative in the patients with acute paraquat poisoning. Chinese Journal of Industrial Hygiene and Occupational Diseases. 32:378–380. 2014.(In Chinese). PubMed/NCBI

19 

Singh AP, Junemann A, Muthuraman A, Jaggi AS, Singh N, Grover K and Dhawan R: Animal models of acute renal failure. Pharmacol Rep. 64:31–44. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Weng CH, Hu CC, Lin JL, Lin-Tan DT, Huang WH, Hsu CW and Yen TH: Sequential organ failure assessment score can predict mortality in patients with paraquat intoxication. PLoS One. 7:e517432012. View Article : Google Scholar : PubMed/NCBI

21 

Huang NC, Hung YM, Lin SL, Wann SR, Hsu CW, Ger LP, Hung SY, Chung HM and Yeh JH: Further evidence of the usefulness of acute physiology and chronic health evaluation II scoring system in acute paraquat poisoning. Clin Toxicol (Phila). 44:99–102. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Chang MW, Chang SS, Lee CC, Sheu BF and Young YR: Hypokalemia and hypothermia are associated with 30-day mortality in patients with acute paraquat poisoning. Am J Med Sci. 335:451–456. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Howell MD, Donnino M, Clardy P, Talmor D and Shapiro NI: Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med. 33:1892–1899. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu XW, Ma T, Li LL, Qu B and Liu Z: Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning. Exp Ther Med 14: 79-86, 2017.
APA
Liu, X., Ma, T., Li, L., Qu, B., & Liu, Z. (2017). Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning. Experimental and Therapeutic Medicine, 14, 79-86. https://doi.org/10.3892/etm.2017.4463
MLA
Liu, X., Ma, T., Li, L., Qu, B., Liu, Z."Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning". Experimental and Therapeutic Medicine 14.1 (2017): 79-86.
Chicago
Liu, X., Ma, T., Li, L., Qu, B., Liu, Z."Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning". Experimental and Therapeutic Medicine 14, no. 1 (2017): 79-86. https://doi.org/10.3892/etm.2017.4463
Copy and paste a formatted citation
x
Spandidos Publications style
Liu XW, Ma T, Li LL, Qu B and Liu Z: Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning. Exp Ther Med 14: 79-86, 2017.
APA
Liu, X., Ma, T., Li, L., Qu, B., & Liu, Z. (2017). Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning. Experimental and Therapeutic Medicine, 14, 79-86. https://doi.org/10.3892/etm.2017.4463
MLA
Liu, X., Ma, T., Li, L., Qu, B., Liu, Z."Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning". Experimental and Therapeutic Medicine 14.1 (2017): 79-86.
Chicago
Liu, X., Ma, T., Li, L., Qu, B., Liu, Z."Predictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning". Experimental and Therapeutic Medicine 14, no. 1 (2017): 79-86. https://doi.org/10.3892/etm.2017.4463
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team