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Review

Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases (Review)

  • Authors:
    • Donatella Perrone
    • Maria Pia Fuggetta
    • Fatima Ardito
    • Andrea Cottarelli
    • Anna De Filippis
    • Giampietro Ravagnan
    • Salvatore De Maria
    • Lorenzo Lo Muzio
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Experimental Medicine, University of Foggia, I‑71122 Foggia, Italy, Institute of Translational Pharmacology, CNR‑Area Torvergata, I‑00133 Rome, Italy, Department of Experimental Medicine, Second University of Napoli, Napoli, I‑80131 Naples, Italy, Glures srl. Operative Unit‑Biochemical and Biophysical Department, I‑80138 Naples, Italy
  • Pages: 3-9
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    Published online on: May 18, 2017
       https://doi.org/10.3892/etm.2017.4472
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Abstract

Health promotion strategies and lifestyle changes are important in disease prevention. Oral health has received a large amount of attention previously as it is a fundamental component of general health and it contributes to the quality of life. Therefore, the study of associations between diet, health and the presence of bioactive compounds in food is receiving a substantial amount of attention. In the present review the effects and targets of a natural polyohenolic stilbenoid compound; resveratrol (3,5,4'‑trihydroxystilbene; RSV) is assessed, and the future prospects for RSV in promoting oral health are considered. RSV is a phytoalexin, synthesized by a wide range of plants and abundantly extracted in grape skin, it has been purported to exert a multiplicity of anti‑inflammatory, anti‑viral, anti‑microbial, estrogenic, anticancer, cardioprotective, neuroprotective and immunomodulatory functions. In this review, following an introduction documenting the biochemistry of RSV and RSV glucosides, the bioavailability and pharmacokinetics of RSV are described. Considering its multiple properties, the present review has focused on the potential benefits of RSV as an antioxidant and chemopreventive agent.
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1 

Petersen PE: Oral cancer prevention and control-the approach of the World Health Organization. Oral Oncol. 45:454–460. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Petersen PE: World Health Organization global policy for improvement of oral health-World Health Assembly 2007. Int Dent J. 58:115–121. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Marthaler TM and Petersen PE: Salt fluoridation-an alternative in automatic prevention of dental caries. Int Dent J. 55:351–358. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Petersen PE: Tobacco and oral health-the role of the World Health Organization. Oral Health Prev Dent. 1:309–315. 2003.PubMed/NCBI

5 

Petersen PE, Bourgeois D, Bratthall D and Ogawa H: Oral health information systems-towards measuring progress in oral health promotion and disease prevention. Bull World Health Organ. 83:686–693. 2005.PubMed/NCBI

6 

Moynihan P and Petersen PE: Diet, nutrition and the prevention of dental diseases. Public Health Nutr. 7:201–226. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Moynihan PJ: The role of diet and nutrition in the etiology and prevention of oral diseases. Bull World Health Organ. 83:694–699. 2005.PubMed/NCBI

8 

Oral Health Worldwide, . A report by FDI World Dental Federation. FDI World Dental Federation; Geneva: 2014

9 

Nagpal M and Sood S: Role of curcumin in systemic and oral health: An overview. J Nat Sci Biol Med. 4:3–7. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Elattar TM and Virji AS: The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro. Anticancer Res. 20:1733–1738. 2000.PubMed/NCBI

11 

Ramshankar V and Krishnamurthy A: Chemoprevention of oral cancer: Green tea experience. J Nat Sci Biol Med. 5:3–7. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Duan J, Yue W, E J, Malhotra J, Lu SE, Gu J, Xu F and Tan XL: In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells. Sci Rep. 6:316722016. View Article : Google Scholar : PubMed/NCBI

13 

Tao W, Xu X, Wang X, Li B, Wang Y, Li Y and Yang L: Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease. J Ethnopharmacol. 145:1–10. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Jiang M, Lu C, Chen G, Xiao C, Zha Q, Niu X, Chen S and Lu A: Understanding the molecular mechanism of interventions in treating rheumatoid arthritis patients with corresponding traditional Chinese medicine patterns based on bioinformatics approach. Evid Based Complement Alternat Med. 2012:1294522012. View Article : Google Scholar : PubMed/NCBI

15 

Li S and Zhang B: Traditional Chinese medicine network pharmacology: Theory, methodology and application. Chin J Nat Med. 11:110–120. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S and Takada Y: Role of resveratrol in prevention and therapy of cancer: Preclinical and clinical studies. Anticancer Res. 24:2783–2840. 2004.PubMed/NCBI

17 

Pervaiz S and Holme AL: Resveratrol: Its biologic targets and functional activity. Antioxid Redox Signal. 11:2851–2897. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Harikumar KB and Aggarwal BB: Resveratrol: A multitargeted agent for age-associated chronic diseases. Cell Cycle. 7:1020–1035. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Athar M, Back JH, Kopelovich L, Bickers DR and Kim AL: Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch Biochem Biophys. 486:95–102. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Kerem Z, Chetrit D, Shoseyov O and Regev-Shoshani G: Protection of lipids from oxidation by epicatechin, trans-resveratrol, and gallic and caffeic acids in intestinal model systems. J Agric Food Chem. 54:10288–10293. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Murias M, Handler N, Erker T, Pleban K, Ecker G, Saiko P, Szekeres T and Jäger W: Resveratrol analogues as selective cyclooxygenase-2 inhibitors: Synthesis and structure-activity relationship. Bioorg Med Chem. 12:5571–5578. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Gehm BD, McAndrews JM, Chien PY and Jameson JL: Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci USA. 94:pp. 14138–14143. 1997; View Article : Google Scholar : PubMed/NCBI

23 

Kraft TE, Parisotto D, Schempp C and Efferth T: Fighting cancer with red wine? Molecular mechanisms of resveratrol. Crit Rev Food Sci Nutr. 49:782–799. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Benová B, Adam M, Onderková K, Královsky J and Krajicek M: Analysis of selected stilbenes in Polygonum cuspidatum by HPLC coupled with CoulArray detection. J Sep Sci. 31:2404–2409. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Wu JM, Wang ZR, Hsieh TC, Bruder JL, Zou JG and Huang YZ: Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review). Int J Mol Med. 8:3–17. 2001.PubMed/NCBI

26 

Jung JC, Lim E, Lee Y, Kang JM, Kim H, Jang S, Oh S and Jung M: Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects. Eur J Med Chem. 44:3166–3174. 2009. View Article : Google Scholar : PubMed/NCBI

27 

King RE, Kent KD and Bomser JA: Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact. 151:143–149. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Saiko P, Szakmary A, Jaeger W and Szekeres T: Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad? Mutat Res. 658:68–94. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Szekeres T, Fritzer-Szekeres M, Saiko P and Jäger W: Resveratrol and resveratrol analogues-structure-activity relationship. Pharm Res. 27:1042–1048. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Szekeres T, Saiko P, Fritzer-Szekeres M, Djavan B and Jäger W: Chemopreventive effects of resveratrol and resveratrol derivatives. Ann N Y Acad Sci. 1215:89–95. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Piotrowska H, Kucinska M and Murias M: Biological activity of piceatannol: Leaving the shadow of resveratrol. Mutat Res. 750:60–82. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Petrovski G, Gurusamy N and Das DK: Resveratrol in cardiovascular health and disease. Ann N Y Acad Sci. 1215:22–33. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Ndiaye M, Philippe C, Mukhtar H and Ahmad N: The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges. Arch Biochem Biophys. 508:164–170. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Szkudelska K and Szkudelski T: Resveratrol, obesity and diabetes. Eur J Pharmacol. 635:1–8. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Wahba MG, Messiha BA and Abo-Saif AA: Protective effects of fenofibrate and resveratrol in an aggressive model of rheumatoid arthritis in rats. Pharm Biol. 54:1705–1715. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Bastianetto S, Ménard C and Quirion R: Neuroprotective action of resveratrol. Biochim Biophys Acta. 1852:1195–1201. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Markus MA and Morris BJ: Resveratrol in prevention and treatment of common clinical conditions of aging. Clin Interv Aging. 3:331–339. 2008.PubMed/NCBI

38 

Frémont L: Biological effects of resveratrol. Life Sci. 66:663–673. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Wang W, Tang K, Yang HR, Wen PF, Zhang P, Wang HL and Huang WD: Distribution of resveratrol and stilbene synthase in young grape plants (Vitis vinifera L. cv. Cabernet Sauvignon) and the effect of UV-C on its accumulation. Plant Physiol Biochem. 48:142–152. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Soleas GJ, Diamandis EP and Goldberg DM: Resveratrol: A molecule whose time has come? And gone? Clin Biochem. 30:91–113. 1997. View Article : Google Scholar : PubMed/NCBI

41 

Vastano BC, Chen Y, Zhu N, Ho CT, Zhou Z and Rosen RT: Isolation and identification of stilbenes in two varieties of Polygonum cuspidatum. J Agric Food Chem. 48:253–256. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Hathway DE and Seakins JW: Hydroxystilbenes of Eucalyptus wandoo. Biochem J. 72:369–374. 1959. View Article : Google Scholar : PubMed/NCBI

43 

Rolfs CH and Kindl H: Stilbene synthase and chalcone synthase: Two different constitutive enzymes in cultured cells of Picea excelsa. Plant Physiol. 75:489–492. 1984. View Article : Google Scholar : PubMed/NCBI

44 

King RE, Bomser JA and Min DB: Bioactivity of resveratrol. Comprehensive Reviews in Food Science and Food Safety. 5:65–70. 2006. View Article : Google Scholar

45 

Takaoka MJ: The phenolic substances of white hellebore (Veratrum grandiflorum Loes. fil.). J Faculty Sci. 3:1–16. 1940.

46 

Baur JA and Sinclair DA: Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Drug Discov. 5:493–506. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Langcake P and Pryce RJ: A new class of phytoalexins from grapevines. Experientia. 33:151–152. 1977. View Article : Google Scholar : PubMed/NCBI

48 

Renaud S and de Lorgeril M: Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 339:1523–1526. 1992. View Article : Google Scholar : PubMed/NCBI

49 

Counet C, Callemien D and Collin S: Chocolate and cocoa: New sources of trans-resveratrol and trans-piceid. Food Chemistry. 98:649–657. 2006. View Article : Google Scholar

50 

Wang Y, Catana F, Yang Y, Roderick R and van Breemen RB: An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine. J Agric Food Chem. 50:431–435. 2002. View Article : Google Scholar : PubMed/NCBI

51 

Siemann EH and Creasy LL: Concentration of the Phytoalexin resveratrol in wine. Am J Enol Vitic. 43:49–52. 1992.

52 

Guerrero RF, Garcia-Parrilla MC, Puertas B and Cantos-Villar E: Wine, resveratrol and health: A review. Nat Prod Commun. 4:635–658. 2009.PubMed/NCBI

53 

Stervbo U, Vang O and Bonnesen C: A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine. Food Chemistry. 101:449–457. 2007. View Article : Google Scholar

54 

Figueiras TS, Neves-Petersen MT and Petersen SB: Activation energy of light induced isomerization of resveratrol. J Fluoresc. 21:1897–1906. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Cai YJ, Wei QY, Fang JG, Yang L, Liu ZL, Wyche JH and Han Z: The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and apoptotic activities. Anticancer Res. 24:999–1002. 2004.PubMed/NCBI

56 

Wieder T, Prokop A, Bagci B, Essmann F, Bernicke D, Schulze-Osthoff K, Dörken B, Schmalz HG, Daniel PT and Henze G: Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts. Leukemia. 15:1735–1742. 2001. View Article : Google Scholar : PubMed/NCBI

57 

Yang T, Wang L, Zhu M, Zhang L and Yan L: Properties and molecular mechanisms of resveratrol: A review. Pharmazie. 70:501–506. 2015.PubMed/NCBI

58 

Biasutto L, Marotta E, Bradaschia A, Fallica M, Mattarei A, Garbisa S, Zoratti M and Paradisi C: Soluble polyphenols: Synthesis and bioavailability of 3,4′,5-tri(alpha-D-glucose-3-O-succinyl) resveratrol. Bioorg Med Chem Lett. 19:6721–6724. 2009. View Article : Google Scholar : PubMed/NCBI

59 

Ratnam DV, Ankola DD, Bhardwaj V, Sahana DK and Kumar MN: Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. J Control Release. 113:189–207. 2006. View Article : Google Scholar : PubMed/NCBI

60 

Lin YL, Chang HC, Chen TL, Chang JH, Chiu WT, Lin JW and Chen RM: Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells. J Nutr. 140:2187–2192. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Du QH, Peng C and Zhang H: Polydatin: A review of pharmacology and pharmacokinetics. Pharm Biol. 51:1347–1354. 2013. View Article : Google Scholar : PubMed/NCBI

62 

Plou FJ, Segura AGd and Ballesteros A: Application of Glycosidases and Transglycosidases in the synthesis of oligosaccharidesIndustrial enzymes: Structure, function and applications. Polaina J and MacCabe AP: Springer; Netherlands, Dordrecht: pp. 141–157. 2007, View Article : Google Scholar

63 

Bertrand A, Morel S, Lefoulon F, Rolland Y, Monsan P and Remaud-Simeon M: Leuconostoc mesenteroides glucansucrase synthesis of flavonoid glucosides by acceptor reactions in aqueous-organic solvents. Carbohydr Res. 341:855–863. 2006. View Article : Google Scholar : PubMed/NCBI

64 

Cichewicz RH and Kouzi SA: Biotransformation of resveratrol to piceid by Bacillus cereus. J Nat Prod. 61:1313–1314. 1998. View Article : Google Scholar : PubMed/NCBI

65 

Baek SJ, Wilson LC and Eling TE: Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. Carcinogenesis. 23:425–434. 2002. View Article : Google Scholar : PubMed/NCBI

66 

Aziz MH, Kumar R and Ahmad N: Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underlying mechanisms (review). Int J Oncol. 23:17–28. 2003.PubMed/NCBI

67 

Walle T, Hsieh F, DeLegge MH, Oatis JE Jr and Walle UK: High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 32:1377–1382. 2004. View Article : Google Scholar : PubMed/NCBI

68 

Marier JF, Vachon P, Gritsas A, Zhang J, Moreau JP and Ducharme MP: Metabolism and disposition of resveratrol in rats: Extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J Pharmacol Exp Ther. 302:369–373. 2002. View Article : Google Scholar : PubMed/NCBI

69 

Belguendouz L, Fremont L and Linard A: Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochem Pharmacol. 53:1347–1355. 1997. View Article : Google Scholar : PubMed/NCBI

70 

Jannin B, Menzel M, Berlot JP, Delmas D, Lancon A and Latruffe N: Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: Plasmatic protein binding and cell uptake. Biochem Pharmacol. 68:1113–1118. 2004. View Article : Google Scholar : PubMed/NCBI

71 

Lançon A, Delmas D, Osman H, Thénot JP, Jannin B and Latruffe N: Human hepatic cell uptake of resveratrol: Involvement of both passive diffusion and carrier-mediated process. Biochem Biophys Res Commun. 316:1132–1137. 2004. View Article : Google Scholar : PubMed/NCBI

72 

Lucas R, Alcantara D and Morales JC: A concise synthesis of glucuronide metabolites of urolithin-B, resveratrol, and hydroxytyrosol. Carbohydr Res. 344:1340–1346. 2009. View Article : Google Scholar : PubMed/NCBI

73 

Bertelli AA, Giovannini L, Stradi R, Bertelli A and Tillement JP: Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4′,5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Int J Tissue React. 18:67–71. 1996.PubMed/NCBI

74 

El Mohsen MA, Marks J, Kuhnle G, Moore K, Debnam E, Srai S Kaila, Rice-Evans C and Spencer JP: Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats. Br J Nutr. 95:51–58. 2006. View Article : Google Scholar : PubMed/NCBI

75 

Vitrac X, Desmoulière A, Brouillaud B, Krisa S, Deffieux G, Barthe N, Rosenbaum J and Mérillon JM: Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Life Sci. 72:2219–2233. 2003. View Article : Google Scholar : PubMed/NCBI

76 

de Santi C, Pietrabissa A, Spisni R, Mosca F and Pacifici GM: Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica. 30:609–617. 2000. View Article : Google Scholar : PubMed/NCBI

77 

Koga CC, Andrade JE, Ferruzzi MG and Lee Y: Stability of trans-resveratrol encapsulated in a protein matrix produced using spray drying to UV light stress and simulated gastro-intestinal digestion. J Food Sci. 81:C292–C300. 2016. View Article : Google Scholar : PubMed/NCBI

78 

Teskac K and Kristl J: The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Int J Pharm. 390:61–69. 2010. View Article : Google Scholar : PubMed/NCBI

79 

Nam JB, Ryu JH, Kim JW, Chang IS and Suh KD: Stabilization of resveratrol immobilized in monodisperse cyano-functionalized porous polymeric microspheres. Polymer. 46:8956–8963. 2005. View Article : Google Scholar

80 

Shi G, Rao L, Yu H, Xiang H, Yang H and Ji R: Stabilization and encapsulation of photosensitive resveratrol within yeast cell. Int J Pharm. 349:83–93. 2008. View Article : Google Scholar : PubMed/NCBI

81 

Kesisoglou F, Panmai S and Wu Y: Nanosizing-oral formulation development and biopharmaceutical evaluation. Adv Drug Deliv Rev. 59:631–644. 2007. View Article : Google Scholar : PubMed/NCBI

82 

Rasenack N and Müller BW: Crystal habit and tableting behavior. Int J Pharm. 244:45–57. 2002. View Article : Google Scholar : PubMed/NCBI

83 

Juan ME, Vinardell MP and Planas JM: The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr. 132:257–260. 2002.PubMed/NCBI

84 

Leonard SS, Xia C, Jiang BH, Stinefelt B, Klandorf H, Harris GK and Shi X: Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun. 309:1017–1026. 2003. View Article : Google Scholar : PubMed/NCBI

85 

Halliwell B and Gutteridge JM: Role of free radicals and catalytic metal ions in human disease: An overview. Methods Enzymol. 186:1–85. 1990. View Article : Google Scholar : PubMed/NCBI

86 

Rizvi SI and Pandey KB: Activation of the erythrocyte plasma membrane redox system by resveratrol: A possible mechanism for antioxidant properties. Pharmacol Rep. 62:726–732. 2010. View Article : Google Scholar : PubMed/NCBI

87 

Das S and Das DK: Anti-inflammatory responses of resveratrol. Inflamm Allergy Drug Targets. 6:168–173. 2007. View Article : Google Scholar : PubMed/NCBI

88 

Birben E, Sahiner UM, Sackesen C, Erzurum S and Kalayci O: Oxidative stress and antioxidant defense. World Allergy Organ J. 5:9–19. 2012. View Article : Google Scholar : PubMed/NCBI

89 

Simon HU, Haj-Yehia A and Levi-Schaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 5:415–418. 2000. View Article : Google Scholar : PubMed/NCBI

90 

Kim CH, Jeon HM, Lee SY, Jeong EK, Ju MK, Park BJ, Park HG, Lim SC, Han SI and Kang HS: Role of reactive oxygen species-dependent protein aggregation in metabolic stress-induced necrosis. Int J Oncol. 37:97–102. 2010.PubMed/NCBI

91 

la Lastra CA and Villegas I: Resveratrol as an antioxidant and pro-oxidant agent: Mechanisms and clinical implications. Biochem Soc Trans. 35:1156–1160. 2007. View Article : Google Scholar : PubMed/NCBI

92 

Azmi AS, Bhat SH, Hanif S and Hadi SM: Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: A putative mechanism for anticancer properties. FEBS Lett. 580:533–538. 2006. View Article : Google Scholar : PubMed/NCBI

93 

Jang M and Pezzuto JM: Cancer chemopreventive activity of resveratrol. Drugs Exp Clin Res. 25:65–77. 1999.PubMed/NCBI

94 

Cao Z and Li Y: Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: Protection against oxidative and electrophilic injury. Eur J Pharmacol. 489:39–48. 2004. View Article : Google Scholar : PubMed/NCBI

95 

Yen GC, Duh PD and Lin CW: Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. Free Radic Res. 37:509–514. 2003. View Article : Google Scholar : PubMed/NCBI

96 

Melov S: Therapeutics against mitochondrial oxidative stress in animal models of aging. Ann N Y Acad Sci. 959:330–340. 2002. View Article : Google Scholar : PubMed/NCBI

97 

Ates O, Cayli SR, Yucel N, Altinoz E, Kocak A, Durak MA, Turkoz Y and Yologlu S: Central nervous system protection by resveratrol in streptozotocin-induced diabetic rats. J Clin Neurosci. 14:256–260. 2007. View Article : Google Scholar : PubMed/NCBI

98 

Belguendouz L, Frémont L and Gozzelino MT: Interaction of transresveratrol with plasma lipoproteins. Biochem Pharmacol. 55:811–816. 1998. View Article : Google Scholar : PubMed/NCBI

99 

Rotondo S, Rajtar G, Manarini S, Celardo A, Rotillo D, De Gaetano G, Evangelista V and Cerletti C: Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br J Pharmacol. 123:1691–1699. 1998. View Article : Google Scholar : PubMed/NCBI

100 

West JD and Marnett LJ: Endogenous reactive intermediates as modulators of cell signaling and cell death. Chem Res Toxicol. 19:173–194. 2006. View Article : Google Scholar : PubMed/NCBI

101 

Lee HS, Kim HN, Jung MH and Choi JY: Electrically evoked potentials recorded in a patient with auditory neuropathy. Cochlear Implants Int. 5 Suppl 1:S2312004. View Article : Google Scholar

102 

Rizvi SI and Maurya PK: Alterations in antioxidant enzymes during aging in humans. Mol Biotechnol. 37:58–61. 2007. View Article : Google Scholar : PubMed/NCBI

103 

Wenzel U, Nickel A and Daniel H: Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. Cell Mol Life Sci. 62:3100–3105. 2005. View Article : Google Scholar : PubMed/NCBI

104 

Guo R, Su Y, Liu B, Li S, Zhou S and Xu Y: Resveratrol suppresses oxidised low-density lipoprotein-induced macrophage apoptosis through inhibition of intracellular reactive oxygen species generation, LOX-1, and the p38 MAPK pathway. Cell Physiol Biochem. 34:603–616. 2014. View Article : Google Scholar : PubMed/NCBI

105 

Dani C, Bonatto D, Salvador M, Pereira MD, Henriques JA and Eleutherio E: Antioxidant protection of resveratrol and catechin in Saccharomyces cerevisiae. J Agric Food Chem. 56:4268–4272. 2008. View Article : Google Scholar : PubMed/NCBI

106 

Naylor AJ Dirks: Cellular effects of resveratrol in skeletal muscle. Life Sci. 84:637–640. 2009. View Article : Google Scholar : PubMed/NCBI

107 

Pandey KB and Rizvi SI: Protective effect of resveratrol on formation of membrane protein carbonyls and lipid peroxidation in erythrocytes subjected to oxidative stress. Appl Physiol Nutr Metab. 34:1093–1097. 2009. View Article : Google Scholar : PubMed/NCBI

108 

Pandey KB and Rizvi SI: Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2:270–278. 2009. View Article : Google Scholar : PubMed/NCBI

109 

Rizvi SI, Jha R and Pandey KB: Activation of erythrocyte plasma membrane redox system provides a useful method to evaluate antioxidant potential of plant polyphenols. Methods Mol Biol. 594:341–348. 2010. View Article : Google Scholar : PubMed/NCBI

110 

Goldberg DM, Yan J and Soleas GJ: Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem. 36:79–87. 2003. View Article : Google Scholar : PubMed/NCBI

111 

Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, Lo Russo L, De Lillo A, Laino L and Lo Muzio L: Biological and therapeutic activities, and anticancer properties of curcumin. Exp Ther Med. 10:1615–1623. 2015.PubMed/NCBI

112 

Maioli E, Torricelli C and Valacchi G: Rottlerin and cancer: Novel evidence and mechanisms. Scientific World Journal. 2012:3508262012. View Article : Google Scholar : PubMed/NCBI

113 

Russo M, Russo GL, Daglia M, Kasi PD, Ravi S, Nabavi SF and Nabavi SM: Understanding genistein in cancer: The ‘good’ and the ‘bad’ effects: A review. Food Chem. 196:589–600. 2016. View Article : Google Scholar : PubMed/NCBI

114 

Brito AF, Ribeiro M, Abrantes AM, Pires AS, Teixo RJ, Tralhão JG and Botelho MF: Quercetin in cancer treatment, alone or in combination with conventional therapeutics? Curr Med Chem. 22:3025–3039. 2015. View Article : Google Scholar : PubMed/NCBI

115 

Zhao X and Zhang J: Mechanisms for quercetin in prevention of lung cancer cell growth and metastasis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 40:592–597. 2015.(In Chinese). PubMed/NCBI

116 

Feitelson MA, Arzumanyan A, Kulathinal RJ, Blain SW, Holcombe RF, Mahajna J, Marino M, Martinez-Chantar ML, Nawroth R, Sanchez-Garcia I, et al: Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol. 35 Suppl:S25–S54. 2015. View Article : Google Scholar : PubMed/NCBI

117 

Yu XD, Yang JL, Zhang WL and Liu DX: Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest. Tumour Biol. 37:2871–2877. 2016. View Article : Google Scholar : PubMed/NCBI

118 

Ray JG, Ranganathan K and Chattopadhyay A: Malignant transformation of oral submucous fibrosis: Overview of histopathological aspects. Oral Surg Oral Med Oral Pathol Oral Radiol. 122:200–209. 2016. View Article : Google Scholar : PubMed/NCBI

119 

Sharma M and Radhakrishnan R: Limited mouth opening in oral submucous fibrosis: Reasons, ramifications, and remedies. J Oral Pathol Med. Oct 15–2016.(Epub ahead of print). View Article : Google Scholar

120 

Chang YC, Lin CW, Yu CC, Wang BY, Huang YH, Hsieh YC, Kuo YL and Chang WW: Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression. Oncotarget. 7:12137–12149. 2016.PubMed/NCBI

121 

Mohan A, Narayanan S, Balasubramanian G, Sethuraman S and Krishnan UM: Dual drug loaded nanoliposomal chemotherapy: A promising strategy for treatment of head and neck squamous cell carcinoma. Eur J Pharm Biopharm. 99:73–83. 2016. View Article : Google Scholar : PubMed/NCBI

122 

ElAttar TM and Virji AS: Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anticancer Drugs. 10:187–193. 1999. View Article : Google Scholar : PubMed/NCBI

123 

Lin FY, Hsieh YH, Yang SF, Chen CT, Tang CH, Chou MY, Chuang YT, Lin CW and Chen MK: Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells. J Oral Pathol Med. 44:699–706. 2015. View Article : Google Scholar : PubMed/NCBI

124 

Masuelli L, Di Stefano E, Fantini M, Mattera R, Benvenuto M, Marzocchella L, Sacchetti P, Focaccetti C, Bernardini R, Tresoldi I, et al: Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas. Oncotarget. 5:10745–10762. 2014. View Article : Google Scholar : PubMed/NCBI

125 

Shan Z, Yang G, Xiang W, Pei-Jun W and Bin Z: Effects of resveratrol on oral squamous cell carcinoma (OSCC) cells in vitro. J Cancer Res Clin Oncol. 140:371–374. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Perrone D, Fuggetta MP, Ardito F, Cottarelli A, De Filippis A, Ravagnan G, De Maria S and Lo Muzio L: Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases (Review). Exp Ther Med 14: 3-9, 2017.
APA
Perrone, D., Fuggetta, M.P., Ardito, F., Cottarelli, A., De Filippis, A., Ravagnan, G. ... Lo Muzio, L. (2017). Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases (Review). Experimental and Therapeutic Medicine, 14, 3-9. https://doi.org/10.3892/etm.2017.4472
MLA
Perrone, D., Fuggetta, M. P., Ardito, F., Cottarelli, A., De Filippis, A., Ravagnan, G., De Maria, S., Lo Muzio, L."Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases (Review)". Experimental and Therapeutic Medicine 14.1 (2017): 3-9.
Chicago
Perrone, D., Fuggetta, M. P., Ardito, F., Cottarelli, A., De Filippis, A., Ravagnan, G., De Maria, S., Lo Muzio, L."Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases (Review)". Experimental and Therapeutic Medicine 14, no. 1 (2017): 3-9. https://doi.org/10.3892/etm.2017.4472
Copy and paste a formatted citation
x
Spandidos Publications style
Perrone D, Fuggetta MP, Ardito F, Cottarelli A, De Filippis A, Ravagnan G, De Maria S and Lo Muzio L: Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases (Review). Exp Ther Med 14: 3-9, 2017.
APA
Perrone, D., Fuggetta, M.P., Ardito, F., Cottarelli, A., De Filippis, A., Ravagnan, G. ... Lo Muzio, L. (2017). Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases (Review). Experimental and Therapeutic Medicine, 14, 3-9. https://doi.org/10.3892/etm.2017.4472
MLA
Perrone, D., Fuggetta, M. P., Ardito, F., Cottarelli, A., De Filippis, A., Ravagnan, G., De Maria, S., Lo Muzio, L."Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases (Review)". Experimental and Therapeutic Medicine 14.1 (2017): 3-9.
Chicago
Perrone, D., Fuggetta, M. P., Ardito, F., Cottarelli, A., De Filippis, A., Ravagnan, G., De Maria, S., Lo Muzio, L."Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases (Review)". Experimental and Therapeutic Medicine 14, no. 1 (2017): 3-9. https://doi.org/10.3892/etm.2017.4472
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