Long-term adefovir therapy may induce Fanconi syndrome: A report of four cases

Pan,Fan; Wang,Yingchao; Zhang,Xin; Lin,Qingfeng; Liu,Xiaolong; Jiang,Yi; Pan,Chen

doi:10.3892/etm.2017.4483

July-2017 Volume 14 Issue 1

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July-2017 Volume 14 Issue 1

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Article

Long-term adefovir therapy may induce Fanconi syndrome: A report of four cases

Authors:
- Fan Pan
- Yingchao Wang
- Xin Zhang
- Qingfeng Lin
- Xiaolong Liu
- Yi Jiang
- Chen Pan
View Affiliations / Copyright

Affiliations: Department of Hepatobiliary Surgery, Fuzhou General Hospital, Fuzhou, Fujian 350001, P.R. China, The Liver Center of Fujian, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China, Department of Gastroenterology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, P.R. China
Pages: 424-430
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Published online on: May 22, 2017

https://doi.org/10.3892/etm.2017.4483
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Abstract

Fanconi syndrome is a rare disease characterized by dysfunction of the proximal renal tubules as a result of various pathogenic events. Drug‑induced Fanconi syndrome may be neglected or misdiagnosed, which increases the level of suffering. The aim of the present study was to conduct an investigation into the effects of adefovir (ADV)-induced Fanconi syndrome. Four typical cases of Fanconi syndrome caused by long‑term ADV therapy (2‑9 years) were diagnosed at our hospital. A complete medical and therapy history was collected from all four patients prior to a physical examination. Laboratory and diagnostic examinations were also conducted. Following this, the patients were diagnosed and a treatment regimen was decided upon. Outcomes of the treatment regimen were observed. Common manifestations of all the four patients were: Renal tubular reabsorption dysfunction; imbalanced electrolyte acid‑base ratio; elevated cystatin C levels; severe hypophosphatemia and diffused systemic pain; osteoporosis; and difficultly walking. When ADV was replaced with supportive treatment, all the four patients exhibited symptom relief. These findings indicate that long‑term ADV therapy may induce Fanconi syndrome. For patients with a history of such therapy, the possibility of Fanconi syndrome should be assessed and monitored closely for indicators, including altered glomerular and renal tubular function. Once diagnosed, the agent should be immediately discontinued and prompt symptomatic treatment should be administered.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Long-term adefovir therapy may induce Fanconi syndrome: A report of four cases

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Abstract

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