Members of the microRNA-200 family are promising therapeutic targets in cancer (Review)

  • Authors:
    • Ying Chen
    • Lei Zhang
  • View Affiliations

  • Published online on: May 22, 2017     https://doi.org/10.3892/etm.2017.4488
  • Pages: 10-17
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Abstract

MicroRNAs (miRs) are non‑coding, single‑stranded RNA molecules that regulate gene expression at the posttranscriptional level. Abnormal expression of miR may result in pathophysiological processes occurring that stimulate the development of various diseases. miRs are commonly dysregulated in cancer and may act as either oncogenes or tumor suppressors. Studies have indicated that members of the miR‑200 family are involved in different aspects of cancer biology, including the epithelial‑to‑mesenchymal transition, tumor angiogenesis and chemoresistance by targeting and repressing the expression of several key messenger RNAs. The present review aims to summarize the role of the miR‑200 family and its potential mechanism of action in tumor progression, which may advance the development of novel therapeutic drugs against tumor metastasis in clinical cancer treatment.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen Y and Chen Y: Members of the microRNA-200 family are promising therapeutic targets in cancer (Review). Exp Ther Med 14: 10-17, 2017
APA
Chen, Y., & Chen, Y. (2017). Members of the microRNA-200 family are promising therapeutic targets in cancer (Review). Experimental and Therapeutic Medicine, 14, 10-17. https://doi.org/10.3892/etm.2017.4488
MLA
Chen, Y., Zhang, L."Members of the microRNA-200 family are promising therapeutic targets in cancer (Review)". Experimental and Therapeutic Medicine 14.1 (2017): 10-17.
Chicago
Chen, Y., Zhang, L."Members of the microRNA-200 family are promising therapeutic targets in cancer (Review)". Experimental and Therapeutic Medicine 14, no. 1 (2017): 10-17. https://doi.org/10.3892/etm.2017.4488