Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Enterovirus 71 infection impairs the reproductive capacity of female mice

  • Authors:
    • Bo Qin
    • Qiuyue Yan
    • Xing Chen
    • Xiuping Xu
    • Yanan Wang
    • Jinkun Chen
    • Xuejun Dong
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory Center, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, P.R. China, Shaoxing Centre for Disease Control and Prevention, Shaoxing, Zhejiang 312000, P.R. China
  • Pages: 403-409
    |
    Published online on: May 23, 2017
       https://doi.org/10.3892/etm.2017.4499
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Enterovirus 71 (EV71) is a major cause of hand, foot and mouth disease (HFMD); however, no clinically approved vaccine or antiviral treatment is currently available for EV71 infection. In the present study, a murine model of EV71 infection was constructed. The clinical isolates of EV71 were amplified in Vero cells and used to challenge adult mice via hydrodynamic injection (HI) and intraperitoneal injection (IP). Following two challenges, >50% of the mice succumbed to EV71 infection. Surviving female mice were identified to have impaired fertility and their litter sizes were significantly decreased compared with the control group. The antibody against EV71‑VP1 persisted in the sera of female mice at a high titer for >2 years after challenge. The maternal antibody in the offspring sera also persisted for ~1 year and disappeared after ~2 years. Results from the present study suggest that a high titer of active EV71 was able to impair the reproductivity of adult female mice, and that high levels of maternal antibody persisted in the offspring and protected postnatal mice from EV71‑induced mortality. The promising antigenicity, immunogenicity and reactogenicity of EV71 suggests that it a potential vaccine target that may be beneficial to the control of HFMD, through immunizing infants and women of reproductive age.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Ye X, Fan C, Ku Z, Zuo T, Kong L, Zhang C, Shi J, Liu Q, Chen T, Zhang Y, et al: Structural basis for recognition of human enterovirus 71 by a bivalent broadly neutralizing monoclonal antibody. PLoS Pathog. 12:e10054542016. View Article : Google Scholar : PubMed/NCBI

2 

Gui J, Liu Z, Zhang T, Hua Q, Jiang Z, Chen B, Gu H, Lv H and Dong C: Epidemiological characteristics and spatial-temporal clusters of hand, foot and mouth disease in zhejiang province, China, 2008–2012. PLoS One. 10:e01391092015. View Article : Google Scholar : PubMed/NCBI

3 

Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, Wang JR and Shih SR: An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med. 341:929–935. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Xu W, Liu CF, Yan L, Li JJ, Wang LJ, Qi Y, Cheng RB and Xiong XY: Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications. Virol J. 9:82012. View Article : Google Scholar : PubMed/NCBI

5 

Qin B, Zhang J, Xie W, Liu X, He T, Chen J and Dong X: Development of a specific latex agglutination test to detect antibodies of enterovirus 71. Arch Med Res. 46:580–587. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Qing J, Wang Y, Sun Y, Huang J, Yan W, Wang J, Su D, Ni C, Li J, Rao Z, et al: Cyclophilin A associates with enterovirus-71 virus capsid and plays an essential role in viral infection as an uncoating regulator. PLoS Pathog. 10:e10044222014. View Article : Google Scholar : PubMed/NCBI

7 

Liu CC, Chow YH, Chong P and Klein M: Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseases. Vaccine. 32:6177–6182. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Liang ZL, Mao QY, Wang YP, Zhu FC, Li JX, Yao X, Gao F, Wu X, Xu M and Wang JZ: Progress on the research and development of inactivated EV71 whole-virus vaccines. Hum Vaccin Immunother. 9:1701–1705. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Ren J, Wang X, Zhu L, Hu Z, Gao Q, Yang P, Li X, Wang J, Shen X, Fry EE, et al: Structures of Coxsackievirus A16 capsids with native antigenicity: Implications for particle expansion, receptor binding and immunogenicity. J Virology. 89:10500–10511. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Chang J, Li J, Wei W, Liu X, Liu G, Yang J, Zhang W and Yu XF: Determinants of EV71 immunogenicity and protection against lethal challenge in a mouse model. Immunol Res. 62:306–315. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Ng Q, He F and Kwang J: Recent Progress towards Novel EV71 anti-therapeutics and vaccines. Viruses. 7:6441–6457. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Li X, Fan P, Jin J, Su W, An D, Xu L, Sun S, Zhang Y, Meng X, Gao F, et al: Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2. Virol J. 10:2502013. View Article : Google Scholar : PubMed/NCBI

13 

Wang YF, Chou CT, Lei HY, Liu CC, Wang SM, Yan JJ, Su IJ, Wang JR, Yeh TM, Chen SH and Yu CK: A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. J Virol. 78:7916–7924. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Shih SR, Li YS, Chiou CC, Suen PC, Lin TY, Chang LY, Huang YC, Tsao KC, Ning HC, Wu TZ and Chan EC: Expression of capsid [correction of caspid] protein VP1 for use as antigen for the diagnosis of enterovirus 71 infection. J Med Virol. 61:228–234. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Bo HT: tCJkZJhJZjHXnFLjQ: A study on genetic characteristics of Enterovirus 71 of hand-foot-mouth disease in Shaoxing city Zhejiang. Prev Med. 26:42014.

16 

Li XD, Li XF, Ye HQ, Deng CL, Ye Q, Shan C, Shang BD, Xu LL, Li SH, Cao SB, et al: Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A. J Gen Virol. 95:806–815. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Chen J, Zhao Y, Zhang C, Chen H, Feng J, Chi X, Pan Y, Du J, Guo M, Cao H, et al: Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Res. 24:1050–1066. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Shang B, Deng C, Ye H, Xu W, Yuan Z, Shi PY and Zhang B: Development and characterization of a stable eGFP enterovirus 71 for antiviral screening. Antiviral Res. 97:198–205. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Qin B, Tu C, Zhang B, He T, Fu L and Xu W: A modified murine model based on hydrodynamic injection for the analysis of chronic human hepatitis B virus infection. Mol Med Rep. 8:1677–1682. 2013.PubMed/NCBI

20 

Qin B, Budeus B, Cao L, Wu C, Wang Y, Zhang X, Rayner S, Hoffmann D, Lu M and Chen X: The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir. Antiviral Res. 97:93–100. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Chen IC, Wang SM, Yu CK and Liu CC: Subneutralizing antibodies to enterovirus 71 induce antibody-dependent enhancement of infection in newborn mice. Med Microbiol Immunol. 202:259–265. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Li P, Yue YY, Song NN, Li ZH and Meng H: Study on BALB/c mice with EV71 infection by diverse inoculation routes. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 27:14–17. 2013.(In Chinese). PubMed/NCBI

23 

Han JF, Yu N, Pan YX, He SJ, Xu LJ, Cao RY, Li YX, Zhu SY, Zhang Y and Qin ED: Phenotypic and genomic characterization of human coxsackievirus A16 strains with distinct virulence in mice. Virus Res. 179:212–219. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Teng S, Wei Y, Zhao SY, Lin XY, Shao QM and Wang J: Intestinal detoxification time of hand-foot-and-mouth disease in children with EV71 infection and the related factors. World J Pediatr. 11:380–385. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Klein MH: EV71 vaccines: A first step towards multivalent hand, foot and mouth disease vaccines. Expert Rev Vaccines. 14:337–340. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qin B, Yan Q, Chen X, Xu X, Wang Y, Chen J and Dong X: Enterovirus 71 infection impairs the reproductive capacity of female mice. Exp Ther Med 14: 403-409, 2017.
APA
Qin, B., Yan, Q., Chen, X., Xu, X., Wang, Y., Chen, J., & Dong, X. (2017). Enterovirus 71 infection impairs the reproductive capacity of female mice. Experimental and Therapeutic Medicine, 14, 403-409. https://doi.org/10.3892/etm.2017.4499
MLA
Qin, B., Yan, Q., Chen, X., Xu, X., Wang, Y., Chen, J., Dong, X."Enterovirus 71 infection impairs the reproductive capacity of female mice". Experimental and Therapeutic Medicine 14.1 (2017): 403-409.
Chicago
Qin, B., Yan, Q., Chen, X., Xu, X., Wang, Y., Chen, J., Dong, X."Enterovirus 71 infection impairs the reproductive capacity of female mice". Experimental and Therapeutic Medicine 14, no. 1 (2017): 403-409. https://doi.org/10.3892/etm.2017.4499
Copy and paste a formatted citation
x
Spandidos Publications style
Qin B, Yan Q, Chen X, Xu X, Wang Y, Chen J and Dong X: Enterovirus 71 infection impairs the reproductive capacity of female mice. Exp Ther Med 14: 403-409, 2017.
APA
Qin, B., Yan, Q., Chen, X., Xu, X., Wang, Y., Chen, J., & Dong, X. (2017). Enterovirus 71 infection impairs the reproductive capacity of female mice. Experimental and Therapeutic Medicine, 14, 403-409. https://doi.org/10.3892/etm.2017.4499
MLA
Qin, B., Yan, Q., Chen, X., Xu, X., Wang, Y., Chen, J., Dong, X."Enterovirus 71 infection impairs the reproductive capacity of female mice". Experimental and Therapeutic Medicine 14.1 (2017): 403-409.
Chicago
Qin, B., Yan, Q., Chen, X., Xu, X., Wang, Y., Chen, J., Dong, X."Enterovirus 71 infection impairs the reproductive capacity of female mice". Experimental and Therapeutic Medicine 14, no. 1 (2017): 403-409. https://doi.org/10.3892/etm.2017.4499
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team