Open Access

Comparison of diagnostic values of ultrasound micro-flow imaging and contrast-enhanced ultrasound for neovascularization in carotid plaques

  • Authors:
    • Hongxue Zhang
    • Jianwen Du
    • Hong Wang
    • Haili Wang
    • Jianhui Jiang
    • Jingjie Zhao
    • Huan Lu
  • View Affiliations

  • Published online on: May 31, 2017     https://doi.org/10.3892/etm.2017.4525
  • Pages: 680-688
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to compare the diagnostic values of ultrasound micro-flow imaging (SMI) and contrast-enhanced ultrasound (CEUS) for neovascularization in carotid plaques, and to investigate their capacities for predicting the risks of cerebral stroke. A total of 39 patients (64 carotid plaques) with severe carotid artery stenosis undergoing carotid endarterectomy were selected between February 2015 and February 2016, and SMI and CEUS were used to detect neovascularization in plaques. According to the CEUS dynamic graph of plaques, the enhanced intensity visual scales and contrast parameters were obtained. Carotid atherosclerotic plaques were divided into 4 groups. The differences in the enhanced intensity visual scales, contrast parameters, and gray-scale median (GSM) values among the 4 groups were analyzed. Carotid plaque tissue samples from patients were stained for CD34, and the consistency of the methods for the diagnosis of neovascularization in plaques was analyzed. The differences in GSM values, enhanced intensities, and enhanced densities among the 4 groups of plaques were statistically significant (F=29.365, χ2=29.025, χ2=30.871, P<0.001); the differences in enhanced intensities of carotid atherosclerotic plaques with different echo types were statistically significant (χ2=17.951, P<0.001). The enhanced intensity of plaques was negatively correlated with the GSM value (r=-0.376, P<0.01), and the enhanced density of plaques was negatively correlated with the GSM value (r=-0.252, P<0.01). SMI and CEUS grading had good consistency (κ=0.860>0), there were statistically significant differences in new vessel densities with different SMI gradings (P<0.001), and the clinical symptoms and severity were positively correlated with SMI grading (rs=0.592>0). In conclusion, SMI and CEUS have good consistency for evaluating neovascularization in carotid plaques, and have good clinical value for evaluating neovascularization in carotid plaques.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang H, Du J, Wang H, Wang H, Jiang J, Zhao J and Lu H: Comparison of diagnostic values of ultrasound micro-flow imaging and contrast-enhanced ultrasound for neovascularization in carotid plaques. Exp Ther Med 14: 680-688, 2017
APA
Zhang, H., Du, J., Wang, H., Wang, H., Jiang, J., Zhao, J., & Lu, H. (2017). Comparison of diagnostic values of ultrasound micro-flow imaging and contrast-enhanced ultrasound for neovascularization in carotid plaques. Experimental and Therapeutic Medicine, 14, 680-688. https://doi.org/10.3892/etm.2017.4525
MLA
Zhang, H., Du, J., Wang, H., Wang, H., Jiang, J., Zhao, J., Lu, H."Comparison of diagnostic values of ultrasound micro-flow imaging and contrast-enhanced ultrasound for neovascularization in carotid plaques". Experimental and Therapeutic Medicine 14.1 (2017): 680-688.
Chicago
Zhang, H., Du, J., Wang, H., Wang, H., Jiang, J., Zhao, J., Lu, H."Comparison of diagnostic values of ultrasound micro-flow imaging and contrast-enhanced ultrasound for neovascularization in carotid plaques". Experimental and Therapeutic Medicine 14, no. 1 (2017): 680-688. https://doi.org/10.3892/etm.2017.4525