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Article

Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation

  • Authors:
    • Da‑Hai Zhao
    • Yu‑Jie Wu
    • Shu‑Ting Liu
    • Rong‑Yu Liu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Second Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Department of Pulmonary Medicine, Anhui Geriatric Institute, The First Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China
  • Pages: 759-764
    |
    Published online on: June 1, 2017
       https://doi.org/10.3892/etm.2017.4534
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Abstract

The present study was performed to assess the protective effect of salvianolic acid B on lipopolysaccharide (LPS)‑induced acute lung injury (ALI). Sprague Dawley rats were injected with 100 µg/kg LPS through a 24‑gauge catheter. One group of rats was pre‑treated with salvianolic acid B (1 mg/ml; 20 ml/kg body weight) 1 h prior to LPS challenge, then 20 ml/kg salvianolic acid B every 2 days for 4 weeks thereafter. Salvianolic acid B attenuated LPS‑induced increases in the lung wet/dry weight rate and lung tissue injury in ALI model rats. LPS‑induced changes in the content of caspase‑3, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, tumor necrosis factor‑α and interleukin‑6 in ALI model rats were attenuated by treatment with salvianolic acid B. Furthermore, treatment with salvianolic acid B inhibited the protein expression of type I collagen I, endogenous transforming growth factor‑β1 production and α‑smooth muscle actin in ALI model rats. These findings indicated that salvianolic acid B attenuates LPS‑induced ALI through inhibition of apoptosis, oxidative stress and inflammation in rats and therefore exertsa protective effect against ALI.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao DH, Wu YJ, Liu ST and Liu RY: Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation. Exp Ther Med 14: 759-764, 2017.
APA
Zhao, D., Wu, Y., Liu, S., & Liu, R. (2017). Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation. Experimental and Therapeutic Medicine, 14, 759-764. https://doi.org/10.3892/etm.2017.4534
MLA
Zhao, D., Wu, Y., Liu, S., Liu, R."Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation". Experimental and Therapeutic Medicine 14.1 (2017): 759-764.
Chicago
Zhao, D., Wu, Y., Liu, S., Liu, R."Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation". Experimental and Therapeutic Medicine 14, no. 1 (2017): 759-764. https://doi.org/10.3892/etm.2017.4534
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao DH, Wu YJ, Liu ST and Liu RY: Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation. Exp Ther Med 14: 759-764, 2017.
APA
Zhao, D., Wu, Y., Liu, S., & Liu, R. (2017). Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation. Experimental and Therapeutic Medicine, 14, 759-764. https://doi.org/10.3892/etm.2017.4534
MLA
Zhao, D., Wu, Y., Liu, S., Liu, R."Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation". Experimental and Therapeutic Medicine 14.1 (2017): 759-764.
Chicago
Zhao, D., Wu, Y., Liu, S., Liu, R."Salvianolic acid B attenuates lipopolysaccharide‑induced acute lung injury in rats through inhibition of apoptosis, oxidative stress and inflammation". Experimental and Therapeutic Medicine 14, no. 1 (2017): 759-764. https://doi.org/10.3892/etm.2017.4534
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