Endobronchial aspergilloma: A case report and literature review

Huang,Dongdong; Li,Bing; Chu,Haiqing; Zhang,Zhemin; Sun,Qiuhong; Zhao,Lan; Xu,Liyun; Shen,Li; Gui,Tao; Xie,Huikang; Zhang,Jun

doi:10.3892/etm.2017.4540

July-2017 Volume 14 Issue 1

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July-2017 Volume 14 Issue 1

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Case Report Open Access

Endobronchial aspergilloma: A case report and literature review

Authors:
- Dongdong Huang
- Bing Li
- Haiqing Chu
- Zhemin Zhang
- Qiuhong Sun
- Lan Zhao
- Liyun Xu
- Li Shen
- Tao Gui
- Huikang Xie
- Jun Zhang
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Affiliations: Department of Clinical Medicine, Tongji University School of Medicine, Shanghai 200092, P.R. China, Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China, Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China, Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Internal Medicine, Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa, IA 52242, USA

Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 547-554
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Published online on: June 1, 2017

https://doi.org/10.3892/etm.2017.4540
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Abstract

The present study aimed to investigate the clinical and radiological characteristics in addition to the bronchoscopic appearance in patients with endobronchial aspergilloma (EBA). Clinical and radiological characteristics were analyzed alongside the bronchoscopic appearance in 17 patients with EBA diagnosed by bronchoscopy with histological examination. The present study assessed the relevant literature and 13 males and 4 females were included in the comparison, with a median age of 59. Associated diseases included 8 previous diagnoses of pulmonary tuberculosis (47.6%), 4 previous diagnoses lung cancer (23.5%), 1 pulmonary resection (5.9%) and 1 bronchial foreign body (5.9%). The primary symptom was hemoptysis (9/17, 53%). Chest computed tomography (CT) indicated a markedly higher incidence of aspergillosis lesion in the left lung (13/17; 76.5%) compared with the right lung (4/17; 23.5%). CT manifestation included space occupying disease in 10 patients (58.8%), aspergilloma in 3 patients (17.6%), pneumonic consolidation in 2 patients (11.8%) and ground glass opacity in 1 patient (5.9%). Bronchoscopy examination identified masses in all 17 patients' bronchial lumen and 15 patients had endobronchial obstruction by necrotic material. The case presented in the current study demonstrated the merits of combining bronchosopic intervention with voriconazole. The dominant symptom of EBA was hemoptysis. Chest CT demonstrated that aspergillosis lesions were more frequently identified in the left lung compared with the right. EBA often occurs in individuals with underlying lung diseases, which cause lumen structural change or bronchial obstruction. EBA may be clearly diagnosed by bronchoscopy biopsy, although the potential for a co‑exististing tumor requires consideration. Bronchoscopic intervention and anti‑fungal therapy may have an advantage in the effective treatment of patients with EBA.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Endobronchial aspergilloma: A case report and literature review

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