Role of nuclear factor (erythroid-derived 2)-like 2 in the age-resistant properties of the glaucoma trabecular meshwork

  • Authors:
    • Jintao Cheng
    • Jiamei Liang
    • Jinze Qi
  • View Affiliations

  • Published online on: June 2, 2017     https://doi.org/10.3892/etm.2017.4543
  • Pages: 791-796
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Abstract

Glaucoma is a major cause of irreversible blindness. Nuclear factor (erythroid-derived 2)‑like 2 (Nrf2) regulates the expression of numerous antioxidants within cells and is therefore a focus of current ophthalmic research. To determine the roles of Nrf2 in mediating the glaucoma trabecular meshwork (GTM), the present study evaluated the levels of Nrf2 expression in GTM and human trabecular meshwork (HTM) cells by reverse‑transcription‑quantitative polymerase chain reaction and western blot analysis. It was principally observed that Nrf2 expression was downregulated in GTM cells. In addition, to determine the influence of Nrf2 on the apoptosis and proliferation of GTM and HTM cells, transfection assays and western blotting were performed to evaluate the expression of apoptosis‑related proteins. The results of the current study indicated that Nrf2 may promote viability and reduce apoptosis in GTM and HTM cells. Collectively, these data suggest that Nrf2 may be a novel therapeutic target to treat glaucoma.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cheng J, Liang J and Qi J: Role of nuclear factor (erythroid-derived 2)-like 2 in the age-resistant properties of the glaucoma trabecular meshwork. Exp Ther Med 14: 791-796, 2017
APA
Cheng, J., Liang, J., & Qi, J. (2017). Role of nuclear factor (erythroid-derived 2)-like 2 in the age-resistant properties of the glaucoma trabecular meshwork. Experimental and Therapeutic Medicine, 14, 791-796. https://doi.org/10.3892/etm.2017.4543
MLA
Cheng, J., Liang, J., Qi, J."Role of nuclear factor (erythroid-derived 2)-like 2 in the age-resistant properties of the glaucoma trabecular meshwork". Experimental and Therapeutic Medicine 14.1 (2017): 791-796.
Chicago
Cheng, J., Liang, J., Qi, J."Role of nuclear factor (erythroid-derived 2)-like 2 in the age-resistant properties of the glaucoma trabecular meshwork". Experimental and Therapeutic Medicine 14, no. 1 (2017): 791-796. https://doi.org/10.3892/etm.2017.4543