Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury

  • Authors:
    • Xiu‑Juan Gao
    • Guan‑Nan Xie
    • Lei Liu
    • Zhi‑Jian Fu
    • Zong‑Wang Zhang
    • Liang‑Zhu Teng
  • View Affiliations

  • Published online on: June 6, 2017     https://doi.org/10.3892/etm.2017.4550
  • Pages: 841-847
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Abstract

The aim of the present study was to evaluate the therapeutic potential of sesamol treatment on focal ischemia/reperfusion (I/R) injury in the rat brain. The results demonstrated that pretreatment with sesamol seven days prior to focal cerebral I/R injury had significant positive effects, including improvements in neurological deficits (P<0.05), and a reduction in malondialdehyde content and elevation of antioxidant levels (superoxide dismutase, glutathione and glutatione peroxidase; both P<0.05). Furthermore, levels of B cell lymphoma‑2 (Bcl‑2)‑associated X protein and caspase‑3 were significantly downregulated, whereas the level of Bcl‑2 was effectively increased. Conversely, the mRNA expression of proinflammatory cytokines were significantly reduced in focal cerebral I/R injury rats upon sesamol intervention. Therefore, the beneficial effects of sesamol on cerebral I/R injury may be due to the reduction of oxidative stress, inhibition of apoptosis and inflammation. The findings of the present study suggest that sesamol supplementation may serve as potent adjuvant in the treatment of focal cerebral ischemia/reperfusion injury due to its neuroprotective effects.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gao XJ, Xie GN, Liu L, Fu ZJ, Zhang ZW and Teng LZ: Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury. Exp Ther Med 14: 841-847, 2017
APA
Gao, X., Xie, G., Liu, L., Fu, Z., Zhang, Z., & Teng, L. (2017). Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury. Experimental and Therapeutic Medicine, 14, 841-847. https://doi.org/10.3892/etm.2017.4550
MLA
Gao, X., Xie, G., Liu, L., Fu, Z., Zhang, Z., Teng, L."Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury". Experimental and Therapeutic Medicine 14.1 (2017): 841-847.
Chicago
Gao, X., Xie, G., Liu, L., Fu, Z., Zhang, Z., Teng, L."Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury". Experimental and Therapeutic Medicine 14, no. 1 (2017): 841-847. https://doi.org/10.3892/etm.2017.4550