Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Cytokine‑induced killer cell therapy for modulating regulatory T cells in patients with non‑small cell lung cancer

  • Authors:
    • Baodan Yu
    • Junli Wang
    • Chen He
    • Wei Wang
    • Jianli Tang
    • Runhui Zheng
    • Chengzhi Zhou
    • Huanhuan Zhang
    • Zhiping Fu
    • Qiasheng Li
    • Jun Xu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China, Department of Respiration, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong 518100, P.R. China, Department of Respiratory Medicine, The Affiliated Shenzhen Bao'an Hospital of Southern Medical University, Shenzhen, Guangdong 518101, P.R. China, Department of Medical Oncology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, P.R. China, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, P.R. China, Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China, Department of Respiratory Medicine, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei 434020, P.R. China
  • Pages: 831-840
    |
    Published online on: June 8, 2017
       https://doi.org/10.3892/etm.2017.4562
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have reported that regulatory T cells (Tregs), which are physiologically engaged in the maintenance of immunological self‑tolerance, have a critical role in the regulation of the antitumor immune response. Targeting Tregs has the potential to augment cancer vaccine approaches. The current study therefore aimed to evaluate the role of cytokine‑induced killer (CIK) cell infusion in modulating Tregs in patients with non‑small cell lung cancer (NSCLC). A total of 15 patients with advanced NSCLC were treated by an infusion of CIK cells derived from autologous peripheral blood mononuclear cells (PBMCs). By using flow cytometry and liquid chip analysis, subsets of T cells and natural killer (NK) cells in peripheral blood, and plasma cytokine profiles in the treated patients, were analyzed at 2 and 4 weeks after CIK cell infusion. Cytotoxicity of PBMCs (n=15) and NK cells (n=6) isolated from NSCLC patients was evaluated before and after CIK cell therapy. Progression‑free survival (PFS) and overall survival (OS) were also assessed. Analysis of the immune cell populations before and after treatment showed a significant increase in NK cells (P<0.05) concomitant with a significant decrease in Tregs (P<0.01) at 2 weeks post‑infusion of CIK cells compared with the baseline. NK group 2D receptor (NKG2D) expression on NK cells was also significantly increased at 2 weeks post‑infusion compared with the baseline (P<0.05). There was a positive correlation between NKG2D expression and the infusion number of CIK cells (P<0.05). When evaluated at 2 weeks after CIK cell therapy, the cytotoxicity of PBMCs and isolated NK cells was significantly increased compared with the baseline (P<0.01 and P<0.05). Correspondingly, plasma cytokine profiles showed significant enhancement of the following antitumor cytokines: Interferon (IFN)‑γ (P<0.05), IFN‑γ‑inducible protein 10 (P<0.01), tumor necrosis factor‑α (P<0.001), granulocyte‑macrophage colony‑stimulating factor (P<0.01), monocyte chemotactic protein‑3 (P<0.01) and interleukin‑21 (P<0.05) at 2 weeks post‑infusion, compared with the baseline. At the same time, the expression of transforming growth factor‑β1, which is primarily produced by Tregs, was significantly decreased compared with the baseline (P<0.05). Median PFS and OS in the CIK cell treatment group were significantly increased compared with the control group (PFS, 9.98 vs. 5.44 months, P=0.038; OS, 24.17 vs. 20.19 months, P=0.048). No severe side-effects were observed during the treatment period. In conclusion, CIK cell therapy was able to suppress Tregs and enhance the antitumor immunity of NK cells in advanced NSCLC patients. Therefore, CIK cell treatment may improve PFS and OS in patients with advanced NSCLC. CIK cell infusion may have therapeutic value for patients with advanced NSCLC, as a treatment that can be combined with chemotherapy and radiotherapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Finotello F and Trajanoski Z: New strategies for cancer immunotherapy: Targeting regulatory T cells. Genome Med. 9:102017. View Article : Google Scholar : PubMed/NCBI

2 

Farashi-Bonab S and Khansari N: Regulatory T cells in cancer patients and their roles in cancer development/progression. MOJ Immunol. 1:00024. 2014.

3 

Chen C, Chen Z, Chen D, Zhang B, Wang Z and Le H: Suppressive effects of gemcitabine plus cisplatin chemotherapy on regulatory T cells in nonsmall-cell lung cancer. J Int Med Res. 43:180–187. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Sakaguchi S, Miyara M, Costantino CM and Hafler DA: FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 10:490–500. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Wang Q, Yang L, Xu F, Wang J, An G and Ma Y: Changes of lymphocyte subgroups in non-small cell lung cancer patients before and during chemotherapy. Clin Lab. 61:1343–1351. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Pan K, Guan XX, Li YQ, Zhao JJ, Li JJ, Qiu HJ, Weng DS, Wang QJ, Liu Q, Huang LX, et al: Clinical activity of adjuvant cytokine-induced killer cell immunotherapy in patients with post-mastectomy triple-negative breast cancer. Clin Cancer Res. 20:3003–3011. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Wang M, Shi SB, Qi JL, Tang XY and Tian J: S-1 plus CIK as second-line treatment for advanced pancreatic cancer. Med Oncol. 30:7472013. View Article : Google Scholar : PubMed/NCBI

8 

Chen JL, Lao XM, Lin XJ, Xu L, Cui BK, Wang J, Lin GH, Shuang ZY, Mao YZ, Huang X, et al: Adjuvant cytokine-induced killer cell therapy improves disease-free and overall survival in solitary and nonmicrovascular invasive hepatocellular carcinoma after curative resection. Medicine (Baltimore). 95:e26652016. View Article : Google Scholar : PubMed/NCBI

9 

Razzaghi H, Quesnel-Crooks S, Sherman R, Joseph R, Kohler B, Andall-Brereton G, Ivey MA, Edwards BK, Mery L, Gawryszewski V and Saraiya M: Leading causes of cancer mortality-Caribbean region, 2003–2013. MMWR Morb Mortal Wkly Rep. 65:1395–1400. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Tian J and Han S: Role of RRM1 in the treatment and prognosis of advanced non-small cell lung cancer. Zhongguo Fei Ai Za Zhi. 18:381–386. 2015.(In Chinese). PubMed/NCBI

11 

Daga A, Ansari A, Patel S, Mirza S, Rawal R and Umrania V: Current drugs and drug targets in non-small cell lung cancer: Limitations and opportunities. Asian Pac J Cancer Prev. 16:4147–4156. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Stein KD, Alteri R and Jemal A: Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 66:271–289. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Vigneron N: Human tumor antigens and cancer immunotherapy. Biomed Res Int. 2015:9485012015. View Article : Google Scholar : PubMed/NCBI

14 

Liu K, Liu X, Peng Z, Sun H, Zhang M, Zhang J, Liu S, Hao L, Lu G, Zheng K, et al: Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging. Oncotarget. 6:23735–23747. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Bigley AB and Simpson RJ: NK cells and exercise: Implications for cancer immunotherapy and survivorship. Discov Med. 19:433–445. 2015.PubMed/NCBI

16 

Ascierto ML, Melero I and Ascierto PA: Melanoma: From incurable beast to a curable bet. The success of immunotherapy. Front Oncol. 5:1522015. View Article : Google Scholar : PubMed/NCBI

17 

Wang M, Cao JX, Pan JH, Liu YS, Xu BL, Li D, Zhang XY, Li JL, Liu JL, Wang HB and Wang ZX: Adoptive immunotherapy of cytokine-induced killer cell therapy in the treatment of non-small cell lung cancer. PLoS One. 9:e1126622014. View Article : Google Scholar : PubMed/NCBI

18 

Zhang J, Zhu L, Du H, He X, Yin Y, Gu Y, Liu L, Lu K, Guo R, Liu P and Shu Y: Autologous cytokine-induced killer cell therapy in lung cancer patients: A retrospective study. Biomed Pharmacother. 70:248–252. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Yang B, Lu XC, Zhu HL, Han WD, Wang Y, Fan H, Li SX, Liu Y, Dai HR and Yao SQ: Clinical study of autologous cytokine induced killer cells combined with IL-2 for therapy of elderly patients with B-cell malignant lymphoma. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 18:1244–1249. 2010.(In Chinese). PubMed/NCBI

20 

Zhang S, He X, Li X and Ren Y: Clinical study on cytokine induced killer cells therapy to laryngeal cancer after radiotherapy. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 25:61–63. 2011.(In Chinese). PubMed/NCBI

21 

Li XD, Ji M, Zheng X, Ning ZH, Wu J, Lu B, Wu CP and Jiang JT: Evaluation of tumor response to cytokine-induced killer cells therapy in malignant solid tumors. J Transl Med. 12:2152014. View Article : Google Scholar : PubMed/NCBI

22 

Walasek T, Sas-Korczyńska B, Dąbrowski T, Reinfuss M, Jakubowicz J, Blecharz P, Łuczyńska E, Darasz Z and Skotnicki P: Palliative thoracic radiotherapy for patients with advanced non-small cell lung cancer and poor performance status. Lung Cancer. 87:130–135. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Kverneland AH, Streitz M, Geissler E, Hutchinson J, Vogt K, Boës D, Niemann N, Pedersen AE, Schlickeiser S and Sawitzki B: Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol. Cytometry A. 89:543–564. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Arias DA Alvarez, Kim HJ, Zhou P, Holderried TA, Wang X, Dranoff G and Cantor H: Disruption of CD8+ Treg activity results in expansion of T follicular helper cells and enhanced antitumor immunity. Cancer Immunol Res. 2:207–216. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Bauer CA, Kim EY, Marangoni F, Carrizosa E, Claudio NM and Mempel TR: Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J Clin Invest. 124:2425–2440. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Guzmán-Flores JM and Portales-Pérez DP: Mechanisms of suppression of regulatory T-cells (Treg). Gac Med Mex. 149:630–638. 2013.(In Spanish). PubMed/NCBI

27 

Duan MC, Zhong XN, Liu GN and Wei JR: The Treg/Th17 paradigm in lung cancer. J Immunol Res. 2014:7303802014. View Article : Google Scholar : PubMed/NCBI

28 

Perrone G, Ruffini PA, Catalano V, Spino C, Santini D, Muretto P, Spoto C, Zingaretti C, Sisti V, Alessandroni P, et al: Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer. Eur J Cancer. 44:1875–1882. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, Harris AL and Banham AH: Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J Clin Oncol. 24:5373–5380. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Mougiakakos D, Choudhury A, Lladser A, Kiessling R and Johansson CC: Regulatory T cells in cancer. Adv Cancer Res. 107:57–117. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Nishikawa H and Sakaguchi S: Regulatory T cells in tumor immunity. Int J Cancer. 127:759–767. 2010.PubMed/NCBI

32 

Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, et al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 10:942–949. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Bergmann C, Strauss L, Wang Y, Szczepanski MJ, Lang S, Johnson JT and Whiteside TL: T regulatory type 1 cells in squamous cell carcinoma of the head and neck: Mechanisms of suppression and expansion in advanced disease. Clin Cancer Res. 14:3706–3715. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Alizadeh D and Larmonier N: Chemotherapeutic targeting of cancer-induced immunosuppressive cells. Cancer Res. 74:2663–2668. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Zhou S, Chen L, Qin J, Li R, Tao H, Zhen Z, Chen H, Chen G, Yang Y, Liu B, et al: Depletion of CD4+ CD25+ regulatory T cells promotes CCL21-mediated antitumor immunity. PLoS One. 8:e739522013. View Article : Google Scholar : PubMed/NCBI

36 

Bulliard Y, Jolicoeur R, Zhang J, Dranoff G, Wilson NS and Brogdon JL: OX40 engagement depletes intratumoral Tregs via activating FcgRs, leading to antitumor efficacy. Immunol Cell Biol. 92:475–480. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Mattarollo SR, Steegh K, Li M, Duret H, Ngiow S Foong and Smyth MJ: Transient Foxp3(+) regulatory T-cell depletion enhances therapeutic anticancer vaccination targeting the immune-stimulatory properties of NKT cells. Immunol Cell Biol. 91:105–114. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Yu N and Li X, Song W, Li D, Yu D, Zeng X, Li M, Leng X and Li X: CD4(+)CD25 (+)CD127 (low/−) T cells: A more specific Treg population in human peripheral blood. Inflammation. 35:1773–1780. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Dasgupta A, Mahapatra M and Saxena R: Flow cytometric immunophenotyping of regulatory T cells in chronic lymphocytic leukemia: Comparative assessment of various markers and use of novel antibody panel with CD127 as alternative to transcription factor FoxP3. Leuk Lymphoma. 54:778–789. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Su H, Longhi MS, Wang P, Vergani D and Ma Y: Human CD4+CD25(high)CD127 (low/neg) regulatory T cells. Methods Mol Biol. 806:287–299. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Drennan S, Stafford ND, Greenman J and Green VL: Increased frequency and suppressive activity of CD127(low/−) regulatory T cells in the peripheral circulation of patients with head and neck squamous cell carcinoma are associated with advanced stage and nodal involvement. Immunology. 140:335–343. 2013.PubMed/NCBI

42 

Jun C, Ke W, Qingshu L, Ping L, Jun D, Jie L, Bo C and Su M: Protective effect of CD4(+)CD25(high)CD127(low) regulatory T cells in renal ischemia-reperfusion injury. Cell Immunol. 289:106–111. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Marek-Trzonkowska N, Myśliwiec M, Dobyszuk A, Grabowska M, Derkowska I, Juścińska J, Owczuk R, Szadkowska A, Witkowski P, Młynarski W, et al: Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up. Clin Immunol. 153:23–30. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Sugiyama D, Nishikawa H, Maeda Y, Nishioka M, Tanemura A, Katayama I, Ezoe S, Kanakura Y, Sato E, Fukumori Y, et al: Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Proc Natl Acad Sci USA. 110:pp. 17945–17950. 2013; View Article : Google Scholar : PubMed/NCBI

45 

Liakou CI, Kamat A, Tang DN, Chen H, Sun J, Troncoso P, Logothetis C and Sharma P: CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci USA. 105:pp. 14987–14992. 2008; View Article : Google Scholar : PubMed/NCBI

46 

Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, Macrae S, Nelson M, Canning C, Lowy I, et al: Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci USA. 105:pp. 3005–3010. 2008; View Article : Google Scholar : PubMed/NCBI

47 

Shimizu J, Yamazaki S and Sakaguchi S: Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity. J Immunol. 163:5211–5218. 1999.PubMed/NCBI

48 

Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, Yamaguchi T, Shimizu J, Nomura T, Chiba T and Sakaguchi S: Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med. 202:885–891. 2005. View Article : Google Scholar : PubMed/NCBI

49 

Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T and Nakayama E: Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res. 59:3128–3133. 1999.PubMed/NCBI

50 

Mitsui J, Nishikawa H, Muraoka D, Wang L, Noguchi T, Sato E, Kondo S, Allison JP, Sakaguchi S, Old LJ, et al: Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. Clin Cancer Res. 16:2781–2791. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Dannull J, Su Z, Rizzieri D, Yang BK, Coleman D, Yancey D, Zhang A, Dahm P, Chao N, Gilboa E and Vieweg J: Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest. 115:3623–3633. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Tao Q, Chen T, Tao L, Wang H, Pan Y, Xiong S and Zhai Z: IL-15 improves the cytotoxicity of cytokine-induced killer cells against leukemia cells by upregulating CD3+CD56+ cells and downregulating regulatory T cells as well as IL-35. J Immunother. 36:462–467. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Ganesan AP, Johansson M, Ruffell B, Yagui-Beltrán A, Lau J, Jablons DM and Coussens LM: Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma. J Immunol. 191:2009–2017. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C, Staehler M, Brugger W, Dietrich PY, Mendrzyk R, et al: Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med. 18:1254–1261. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Lanier LL: NK cell recognition. Annu Rev Immunol. 23:225–274. 2005. View Article : Google Scholar : PubMed/NCBI

56 

McDowell KA, Hank JA, DeSantes KB, Capitini CM, Otto M and Sondel PM: NK cell-based immunotherapies in pediatric oncology. J Pediatr Hematol Oncol. 37:79–93. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Crouse J, Xu HC, Lang PA and Oxenius A: NK cells regulating T cell responses: Mechanisms and outcome. Trends Immunol. 36:49–58. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Sentman CL and Meehan KR: NKG2D CARs as cell therapy for cancer. Cancer J. 20:156–159. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Sarkar S, Germeraad WT, Rouschop KM, Steeghs EM, van Gelder M, Bos GM and Wieten L: Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells. PLoS One. 8:e648352013. View Article : Google Scholar : PubMed/NCBI

60 

Hromadnikova I, Pirkova P and Sedlackova L: Influence of in vitro IL-2 or IL-15 alone or in combination with Hsp-70-derived 14-mer peptide (TKD) on the expression of NK cell activatory and inhibitory receptors. Mediators Inflamm. 2013:4052952013. View Article : Google Scholar : PubMed/NCBI

61 

Konjevic G, Jurisic V, Jovic V, Vuletic A, Martinovic K Mirjacic, Radenkovic S and Spuzic I: Investigation of NK cell function and their modulation in different malignancies. Immunol Res. 52:139–156. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Luo Y, Henning J and O'Donnell MA: Th1 cytokine-secreting recombinant Mycobacterium bovis bacillus Calmette-Guérin and prospective use in immunotherapy of bladder cancer. Clin Dev Immunol. 2011:7289302011. View Article : Google Scholar : PubMed/NCBI

63 

Ito N, Nakamura H, Tanaka Y and Ohgi S: Lung carcinoma: Analysis of T helper type 1 and 2 cells and T cytotoxic type 1 and 2 cells by intracellular cytokine detection with flow cytometry. Cancer. 85:2359–2367. 1999. View Article : Google Scholar : PubMed/NCBI

64 

Romano S, D'Angelillo A, D'Arrigo P, Staibano S, Greco A, Brunetti A, Scalvenzi M, Bisogni R, Scala I and Romano MF: FKBP51 increases the tumour-promoter potential of TGF-beta. Clin Transl Med. 3:12014. View Article : Google Scholar : PubMed/NCBI

65 

Zhuo C, Xu Y, Ying M, Li Q, Huang L, Li D, Cai S and Li B: FOXP3+ Tregs: Heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer. Immunol Res. 61:338–347. 2015. View Article : Google Scholar : PubMed/NCBI

66 

Wilson EB, El-Jawhari JJ, Neilson AL, Hall GD, Melcher AA, Meade JL and Cook GP: Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity. PLoS One. 6:e228422011. View Article : Google Scholar : PubMed/NCBI

67 

Itoh S and Itoh F: Implication of TGF-β as a survival factor during tumour development. J Biochem. 151:559–562. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Du Y, Chen X, Lin XQ, Wu W and Huang ZM: Tumor-derived CD4+CD25+ Tregs inhibit the maturation and antigen-presenting function of dendritic cells. Asian Pac J Cancer Prev. 16:2665–2669. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu B, Wang J, He C, Wang W, Tang J, Zheng R, Zhou C, Zhang H, Fu Z, Li Q, Li Q, et al: Cytokine‑induced killer cell therapy for modulating regulatory T cells in patients with non‑small cell lung cancer. Exp Ther Med 14: 831-840, 2017.
APA
Yu, B., Wang, J., He, C., Wang, W., Tang, J., Zheng, R. ... Xu, J. (2017). Cytokine‑induced killer cell therapy for modulating regulatory T cells in patients with non‑small cell lung cancer. Experimental and Therapeutic Medicine, 14, 831-840. https://doi.org/10.3892/etm.2017.4562
MLA
Yu, B., Wang, J., He, C., Wang, W., Tang, J., Zheng, R., Zhou, C., Zhang, H., Fu, Z., Li, Q., Xu, J."Cytokine‑induced killer cell therapy for modulating regulatory T cells in patients with non‑small cell lung cancer". Experimental and Therapeutic Medicine 14.1 (2017): 831-840.
Chicago
Yu, B., Wang, J., He, C., Wang, W., Tang, J., Zheng, R., Zhou, C., Zhang, H., Fu, Z., Li, Q., Xu, J."Cytokine‑induced killer cell therapy for modulating regulatory T cells in patients with non‑small cell lung cancer". Experimental and Therapeutic Medicine 14, no. 1 (2017): 831-840. https://doi.org/10.3892/etm.2017.4562
Copy and paste a formatted citation
x
Spandidos Publications style
Yu B, Wang J, He C, Wang W, Tang J, Zheng R, Zhou C, Zhang H, Fu Z, Li Q, Li Q, et al: Cytokine‑induced killer cell therapy for modulating regulatory T cells in patients with non‑small cell lung cancer. Exp Ther Med 14: 831-840, 2017.
APA
Yu, B., Wang, J., He, C., Wang, W., Tang, J., Zheng, R. ... Xu, J. (2017). Cytokine‑induced killer cell therapy for modulating regulatory T cells in patients with non‑small cell lung cancer. Experimental and Therapeutic Medicine, 14, 831-840. https://doi.org/10.3892/etm.2017.4562
MLA
Yu, B., Wang, J., He, C., Wang, W., Tang, J., Zheng, R., Zhou, C., Zhang, H., Fu, Z., Li, Q., Xu, J."Cytokine‑induced killer cell therapy for modulating regulatory T cells in patients with non‑small cell lung cancer". Experimental and Therapeutic Medicine 14.1 (2017): 831-840.
Chicago
Yu, B., Wang, J., He, C., Wang, W., Tang, J., Zheng, R., Zhou, C., Zhang, H., Fu, Z., Li, Q., Xu, J."Cytokine‑induced killer cell therapy for modulating regulatory T cells in patients with non‑small cell lung cancer". Experimental and Therapeutic Medicine 14, no. 1 (2017): 831-840. https://doi.org/10.3892/etm.2017.4562
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team