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Article

Coumarins from the roots of Angelica dahurica cause anti‑allergic inflammation

  • Authors:
    • Dong Li
    • Li Wu
  • View Affiliations / Copyright

    Affiliations: Ear, Nose and Throat Department, The First People's Hospital of Jingmen, Jingmen, Hubei 448000, P.R. China, Clinical Laboratory, The First People's Hospital of Jingmen, Jingmen, Hubei 448000, P.R. China
  • Pages: 874-880
    |
    Published online on: June 8, 2017
       https://doi.org/10.3892/etm.2017.4569
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Abstract

Allergic inflammation is induced by allergens and leads to various allergic diseases, including rhinitis, asthma and conjunctivitis. Histamine is important in the pathogenesis of an immunoglobulin E‑dependent allergic reaction and results in the secretion of cytokines associated with inflammation. Angelica dahurica (A. dahurica) is a medicinal plant widely used in China for the treatment of symptoms related to allergic inflammation. The present study investigated the chemical constituents from A. dahurica and evaluated their reductive effect on allergic inflammation. As a result, 15 compounds including 13 coumarins have been identified as isoimperatorin (1), imperatorin (2), oxypeucedanin (3), oxypeucedanin hydrate (4), bergapten (5), byakangelicin (6), phellopterin (7), byakangelicol (8), isopimpinellin (9), xanthotoxol (10), xanthotoxin (11), pimpinellin (12), scopoletin (13), β‑sitosterol (14) and daucosterol (15). Compounds 1‑13 were able to reduce the release of histamine, with compounds 4‑6 exhibiting the most potent activity. Furthermore, compounds 1‑12 were able to inhibit the secretion of tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑4, with compounds 5 and 7 exhibiting the strongest inhibitory effects. These compounds implemented the inhibitory effects on the expression of inflammatory cytokine genes through the inhibition of nuclear factor‑κB activation. Virtual screening by a docking program indicated that compound 3 is a potent histamine H1 receptor antagonist. Additionally, the calculated physicochemical properties of these compounds support most furanocoumarins to be delivered to binding sites and permeate the cell membrane. The present findings contribute to understanding how A. dahurica attenuates allergic inflammation.
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Copy and paste a formatted citation
Spandidos Publications style
Li D and Wu L: Coumarins from the roots of Angelica dahurica cause anti‑allergic inflammation. Exp Ther Med 14: 874-880, 2017.
APA
Li, D., & Wu, L. (2017). Coumarins from the roots of Angelica dahurica cause anti‑allergic inflammation. Experimental and Therapeutic Medicine, 14, 874-880. https://doi.org/10.3892/etm.2017.4569
MLA
Li, D., Wu, L."Coumarins from the roots of Angelica dahurica cause anti‑allergic inflammation". Experimental and Therapeutic Medicine 14.1 (2017): 874-880.
Chicago
Li, D., Wu, L."Coumarins from the roots of Angelica dahurica cause anti‑allergic inflammation". Experimental and Therapeutic Medicine 14, no. 1 (2017): 874-880. https://doi.org/10.3892/etm.2017.4569
Copy and paste a formatted citation
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Spandidos Publications style
Li D and Wu L: Coumarins from the roots of Angelica dahurica cause anti‑allergic inflammation. Exp Ther Med 14: 874-880, 2017.
APA
Li, D., & Wu, L. (2017). Coumarins from the roots of Angelica dahurica cause anti‑allergic inflammation. Experimental and Therapeutic Medicine, 14, 874-880. https://doi.org/10.3892/etm.2017.4569
MLA
Li, D., Wu, L."Coumarins from the roots of Angelica dahurica cause anti‑allergic inflammation". Experimental and Therapeutic Medicine 14.1 (2017): 874-880.
Chicago
Li, D., Wu, L."Coumarins from the roots of Angelica dahurica cause anti‑allergic inflammation". Experimental and Therapeutic Medicine 14, no. 1 (2017): 874-880. https://doi.org/10.3892/etm.2017.4569
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