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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article Open Access

Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery

  • Authors:
    • Xing-Dui Ma
    • Bei-Ping Li
    • De-Ling Wang
    • Wen-Sheng Yang

  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221002, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2148-2152
    |
    Published online on: July 4, 2017
       https://doi.org/10.3892/etm.2017.4717
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Abstract

The present study determined the effect of dexmedetomidine (Dex) combined with flurbiprofen axetil (FA) on analgesia, immune response, and preservation of cognitive function in patients subjected to general anesthesia. We recruited 100 patients with thyroid surgery and randomly divided them into four groups: Dex (D), FA (F), Dex combined with FA (DF), and saline control (C). The extubation and recovery times for Groups D and DF were significantly longer than for Groups F and C. After extubation, the heart rate and mean arterial pressure for Groups F, D, and DF were significantly lower than for Group C, and data for Group DF was significantly lower than for Group F. The visual analog scale and Riker sedation agitation scores were significantly lower in Group DF than for the other three groups. T- and B-lymphocytes were significantly higher in Group DF than in the other three groups. Compared with Groups F and C, the levels of TNF-α and IL-6 in Group DF were significantly reduced, while IL-2 markedly increased. The combined use of Dex and FA significantly improved pain after general anesthesia thyroid surgery, reduced restlessness and postoperative cognitive dysfunction, enhanced immune function, and promoted wound repair.

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Copy and paste a formatted citation
Spandidos Publications style
Ma X, Li B, Wang D and Yang W: Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery. Exp Ther Med 14: 2148-2152, 2017.
APA
Ma, X., Li, B., Wang, D., & Yang, W. (2017). Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery. Experimental and Therapeutic Medicine, 14, 2148-2152. https://doi.org/10.3892/etm.2017.4717
MLA
Ma, X., Li, B., Wang, D., Yang, W."Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery". Experimental and Therapeutic Medicine 14.3 (2017): 2148-2152.
Chicago
Ma, X., Li, B., Wang, D., Yang, W."Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2148-2152. https://doi.org/10.3892/etm.2017.4717
Copy and paste a formatted citation
x
Spandidos Publications style
Ma X, Li B, Wang D and Yang W: Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery. Exp Ther Med 14: 2148-2152, 2017.
APA
Ma, X., Li, B., Wang, D., & Yang, W. (2017). Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery. Experimental and Therapeutic Medicine, 14, 2148-2152. https://doi.org/10.3892/etm.2017.4717
MLA
Ma, X., Li, B., Wang, D., Yang, W."Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery". Experimental and Therapeutic Medicine 14.3 (2017): 2148-2152.
Chicago
Ma, X., Li, B., Wang, D., Yang, W."Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2148-2152. https://doi.org/10.3892/etm.2017.4717
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