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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article Open Access

Silica nanoparticle‑based dual‑responsive nanoprodrug system for liver cancer therapy

  • Authors:
    • Qing Xia
    • Lina Li
    • Liran Zhao

  • View Affiliations / Copyright

    Affiliations: Department of Digestive Internal Medicine, Daqing LongNan Hospital, Daqing, Heilongjiang 163453, P.R. China
    Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2071-2077
    |
    Published online on: July 11, 2017
       https://doi.org/10.3892/etm.2017.4768
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Abstract

A thiol‑terminated polyethyleneglycol (PEG)‑paclitaxel (PTX) conjugate was synthesized and utilized to construct a novel drug delivery system with thiol‑functionalized silica nanoparticles (SLNs) to improve the overall performance of PTX in liver cancer therapy. Drug loading was performed by coating the PTX conjugate on the surface of SLNs. The PTX‑PEG/SLNs showed a binary responsive drug release behavior to esterase as well as high concentrations of glutathione. The synergic effects of these cancer cell‑specific factors on the release characteristics of PTX‑PEG/SLNs resulted in a significantly (P<0.01) elevated anti‑cancer efficiency. This included prolonged circulation and passive tumor‑targeting properties in vivo due to surface modification of PEG and targeted release of PTX inside tumor cells, which resulted in increased anti‑cancer efficiency. Improving the in vitro properties of PTX‑PEG/SLNs not only significantly (P<0.01) enhanced its therapeutic efficacy in a murine liver cancer model, but rendered these drug‑conjugated SLNs a promising nanoprodrug system for potential use as clinical cancer therapeutics.

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Copy and paste a formatted citation
Spandidos Publications style
Xia Q, Li L and Zhao L: Silica nanoparticle‑based dual‑responsive nanoprodrug system for liver cancer therapy. Exp Ther Med 14: 2071-2077, 2017.
APA
Xia, Q., Li, L., & Zhao, L. (2017). Silica nanoparticle‑based dual‑responsive nanoprodrug system for liver cancer therapy. Experimental and Therapeutic Medicine, 14, 2071-2077. https://doi.org/10.3892/etm.2017.4768
MLA
Xia, Q., Li, L., Zhao, L."Silica nanoparticle‑based dual‑responsive nanoprodrug system for liver cancer therapy". Experimental and Therapeutic Medicine 14.3 (2017): 2071-2077.
Chicago
Xia, Q., Li, L., Zhao, L."Silica nanoparticle‑based dual‑responsive nanoprodrug system for liver cancer therapy". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2071-2077. https://doi.org/10.3892/etm.2017.4768
Copy and paste a formatted citation
x
Spandidos Publications style
Xia Q, Li L and Zhao L: Silica nanoparticle‑based dual‑responsive nanoprodrug system for liver cancer therapy. Exp Ther Med 14: 2071-2077, 2017.
APA
Xia, Q., Li, L., & Zhao, L. (2017). Silica nanoparticle‑based dual‑responsive nanoprodrug system for liver cancer therapy. Experimental and Therapeutic Medicine, 14, 2071-2077. https://doi.org/10.3892/etm.2017.4768
MLA
Xia, Q., Li, L., Zhao, L."Silica nanoparticle‑based dual‑responsive nanoprodrug system for liver cancer therapy". Experimental and Therapeutic Medicine 14.3 (2017): 2071-2077.
Chicago
Xia, Q., Li, L., Zhao, L."Silica nanoparticle‑based dual‑responsive nanoprodrug system for liver cancer therapy". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2071-2077. https://doi.org/10.3892/etm.2017.4768
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