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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

DL‑3‑n‑butylphthalide protects endothelial cells against advanced glycation end product‑induced injury by attenuating oxidative stress and inflammation responses

  • Authors:
    • Chang‑Yun Liu
    • Zhen‑Hua Zhao
    • Zhi‑Ting Chen
    • Chun‑Hui Che
    • Zhang‑Yu Zou
    • Xiao‑Min Wu
    • Sheng‑Gen Chen
    • Yuan‑Xiao Li
    • Han‑Bin Lin
    • Xiao‑Fan Wei
    • Jie You
    • Hua‑Pin Huang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, Department of Neurology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, Department of Endocrinology, Union Hospital, Fujian Medical University, Fujian Endocrinology Institute, Fuzhou, Fujian 350001, P.R. China
  • Pages: 2241-2248
    |
    Published online on: July 12, 2017
       https://doi.org/10.3892/etm.2017.4784
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Abstract

Endothelial dysfunction, regarded as a key step in the pathophysiological course of diabetic vascular complications, is initiated and deteriorated by advanced glycation end products (AGEs). DL‑3‑n‑butylphthalide (DL‑NBP) has been proven to have protective effects on neurons and vascular endothelial cells against ischemic and anoxic damage. The aim of the present study was to investigate whether NBP is able to attenuate AGE‑induced endothelial dysfunction in vitro, and also elucidate the possible underlying mechanism. An injury model of human umbilical vein endothelial cells (HUVECs) induced by AGEs (200 µg/ml) was established. The results demonstrated that pretreatment with NBP (1‑100 µM) significantly increased HUVEC viability and inhibited the apoptosis induced by AGEs. In addition, AGEs stimulated the expression levels of the receptor for AGEs protein and the downstream protein nuclear factor‑κB in HUVECs, which were inhibited by pretreatment with NBP. Furthermore, it significantly reduced reactive oxygen species generation and the level of the inflammatory cytokines, intercellular cell adhesion molecule‑1 and monocyte chemotactic protein‑1, in HUVECs mediated by AGEs. The current findings indicated that NBP attenuated AGE‑induced endothelial dysfunction by ameliorating inflammation and oxidative stress responses.

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Copy and paste a formatted citation
Spandidos Publications style
Liu CY, Zhao ZH, Chen ZT, Che CH, Zou ZY, Wu XM, Chen SG, Li YX, Lin HB, Wei XF, Wei XF, et al: DL‑3‑n‑butylphthalide protects endothelial cells against advanced glycation end product‑induced injury by attenuating oxidative stress and inflammation responses. Exp Ther Med 14: 2241-2248, 2017.
APA
Liu, C., Zhao, Z., Chen, Z., Che, C., Zou, Z., Wu, X. ... Huang, H. (2017). DL‑3‑n‑butylphthalide protects endothelial cells against advanced glycation end product‑induced injury by attenuating oxidative stress and inflammation responses. Experimental and Therapeutic Medicine, 14, 2241-2248. https://doi.org/10.3892/etm.2017.4784
MLA
Liu, C., Zhao, Z., Chen, Z., Che, C., Zou, Z., Wu, X., Chen, S., Li, Y., Lin, H., Wei, X., You, J., Huang, H."DL‑3‑n‑butylphthalide protects endothelial cells against advanced glycation end product‑induced injury by attenuating oxidative stress and inflammation responses". Experimental and Therapeutic Medicine 14.3 (2017): 2241-2248.
Chicago
Liu, C., Zhao, Z., Chen, Z., Che, C., Zou, Z., Wu, X., Chen, S., Li, Y., Lin, H., Wei, X., You, J., Huang, H."DL‑3‑n‑butylphthalide protects endothelial cells against advanced glycation end product‑induced injury by attenuating oxidative stress and inflammation responses". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2241-2248. https://doi.org/10.3892/etm.2017.4784
Copy and paste a formatted citation
x
Spandidos Publications style
Liu CY, Zhao ZH, Chen ZT, Che CH, Zou ZY, Wu XM, Chen SG, Li YX, Lin HB, Wei XF, Wei XF, et al: DL‑3‑n‑butylphthalide protects endothelial cells against advanced glycation end product‑induced injury by attenuating oxidative stress and inflammation responses. Exp Ther Med 14: 2241-2248, 2017.
APA
Liu, C., Zhao, Z., Chen, Z., Che, C., Zou, Z., Wu, X. ... Huang, H. (2017). DL‑3‑n‑butylphthalide protects endothelial cells against advanced glycation end product‑induced injury by attenuating oxidative stress and inflammation responses. Experimental and Therapeutic Medicine, 14, 2241-2248. https://doi.org/10.3892/etm.2017.4784
MLA
Liu, C., Zhao, Z., Chen, Z., Che, C., Zou, Z., Wu, X., Chen, S., Li, Y., Lin, H., Wei, X., You, J., Huang, H."DL‑3‑n‑butylphthalide protects endothelial cells against advanced glycation end product‑induced injury by attenuating oxidative stress and inflammation responses". Experimental and Therapeutic Medicine 14.3 (2017): 2241-2248.
Chicago
Liu, C., Zhao, Z., Chen, Z., Che, C., Zou, Z., Wu, X., Chen, S., Li, Y., Lin, H., Wei, X., You, J., Huang, H."DL‑3‑n‑butylphthalide protects endothelial cells against advanced glycation end product‑induced injury by attenuating oxidative stress and inflammation responses". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2241-2248. https://doi.org/10.3892/etm.2017.4784
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