Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis

  • Authors:
    • Vânia Teixeira De Andrade
    • Andréa Prestes Nácul
    • Betânia Rodrigues Dos Santos
    • Sheila Bünecker Lecke
    • Poli Mara Spritzer
    • Débora Martinho Morsch
  • View Affiliations

  • Published online on: July 13, 2017     https://doi.org/10.3892/etm.2017.4794
  • Pages: 2317-2322
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Abstract

Current data are inconsistent regarding the association between interleukin‑6 (IL‑6), a marker of acute phase inflammation, and pelvic endometriosis. The aim of the present study was to assess IL‑6 levels in serum and peritoneal fluid (PF), as well as IL‑6 gene expression in adipose tissue (AT) and endometrial samples in pelvic endometriosis. A total of 30 patients with endometriosis and 18 women with a normal pelvis were enrolled in this case‑control study. IL‑6 levels in PF and serum were determined using a human enzyme‑linked immunosorbent assay and IL‑6 gene expression was evaluated using reverse transcription‑quantitative polymerase chain reaction. It was observed that IL‑6 levels in the PF were higher in patients with endometriosis than in the control group (P=0.047) and patients with stage III/IV endometriosis exhibited higher IL‑6 levels in the PF than those with stage I/II endometriosis and the control group (P<0.001). Furthermore, a strong correlation between PF IL‑6 levels and the revised American Society for Reproductive Medicine score for endometriosis severity was identified (r=0.77; P<0.001). IL‑6 gene expression did not differ significantly between endometriosis and control groups in endometrial samples or in AT of both groups. The results of the current study suggest that there may be an association between IL‑6 and the presence and severity of pelvic endometriosis. The source of this higher IL‑6 seems not to be specifically related to regional AT.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
De Andrade VT, Nácul AP, Dos Santos BR, Lecke SB, Spritzer P and Morsch DM: Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis. Exp Ther Med 14: 2317-2322, 2017
APA
De Andrade, V.T., Nácul, A.P., Dos Santos, B.R., Lecke, S.B., Spritzer, P., & Morsch, D.M. (2017). Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis. Experimental and Therapeutic Medicine, 14, 2317-2322. https://doi.org/10.3892/etm.2017.4794
MLA
De Andrade, V. T., Nácul, A. P., Dos Santos, B. R., Lecke, S. B., Spritzer, P., Morsch, D. M."Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis". Experimental and Therapeutic Medicine 14.3 (2017): 2317-2322.
Chicago
De Andrade, V. T., Nácul, A. P., Dos Santos, B. R., Lecke, S. B., Spritzer, P., Morsch, D. M."Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2317-2322. https://doi.org/10.3892/etm.2017.4794