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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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Roux‑en‑Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats

  • Authors:
    • Jia‑Yu Liu
    • Song Mu
    • Shu‑Ping Zhang
    • Wei Guo
    • Qi‑Fu Li
    • Xiao‑Qiu Xiao
    • Jun Zhang
    • Zhi‑Hong Wang

  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Laboratory of Lipid and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2536-2542
    |
    Published online on: July 18, 2017
       https://doi.org/10.3892/etm.2017.4801
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Abstract

The present study aimed to explore the effect of Roux‑en‑Y gastric bypass (RYGB) surgery on protein tyrosine phosphatase 1B (PTP1B) expression levels and leptin activity in hypothalami of obese rats. Obese rats induced by a high‑fat diet (HFD) that underwent RYGB (n=11) or sham operation (SO, n=9), as well as an obese control cohort (Obese, n=10) and an additional normal‑diet group (ND, n=10) were used. Food efficiency was measured at 8 weeks post‑operation. Plasma leptin levels were evaluated and hypothalamic protein tyrosine phosphatase 1B (PTP1B) levels and leptin signaling activity were examined at the genetic and protein levels. The results indicated that food efficiency was typically lower in RYGB rats compared with that in the Obese and SO rats. In the RYGB group, leptin receptor expression and proopiomelanocortin was significantly higher, while Neuropeptide Y levels were lower than those in the Obese and SO groups. Furthermore, the gene and protein expression levels of PTP1B in the RYGB group were lower, while levels of phosphorylated signal transducer and activator of transcription 3 protein were much higher compared with those in the Obese and SO groups. In conclusion, RYGB surgery significantly suppressed hypothalamic PTP1B protein expression. PTP1B regulation may partially alleviate leptin resistance.

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Copy and paste a formatted citation
Spandidos Publications style
Liu JY, Mu S, Zhang SP, Guo W, Li QF, Xiao XQ, Zhang J and Wang ZH: Roux‑en‑Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats. Exp Ther Med 14: 2536-2542, 2017.
APA
Liu, J., Mu, S., Zhang, S., Guo, W., Li, Q., Xiao, X. ... Wang, Z. (2017). Roux‑en‑Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats. Experimental and Therapeutic Medicine, 14, 2536-2542. https://doi.org/10.3892/etm.2017.4801
MLA
Liu, J., Mu, S., Zhang, S., Guo, W., Li, Q., Xiao, X., Zhang, J., Wang, Z."Roux‑en‑Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats". Experimental and Therapeutic Medicine 14.3 (2017): 2536-2542.
Chicago
Liu, J., Mu, S., Zhang, S., Guo, W., Li, Q., Xiao, X., Zhang, J., Wang, Z."Roux‑en‑Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2536-2542. https://doi.org/10.3892/etm.2017.4801
Copy and paste a formatted citation
x
Spandidos Publications style
Liu JY, Mu S, Zhang SP, Guo W, Li QF, Xiao XQ, Zhang J and Wang ZH: Roux‑en‑Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats. Exp Ther Med 14: 2536-2542, 2017.
APA
Liu, J., Mu, S., Zhang, S., Guo, W., Li, Q., Xiao, X. ... Wang, Z. (2017). Roux‑en‑Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats. Experimental and Therapeutic Medicine, 14, 2536-2542. https://doi.org/10.3892/etm.2017.4801
MLA
Liu, J., Mu, S., Zhang, S., Guo, W., Li, Q., Xiao, X., Zhang, J., Wang, Z."Roux‑en‑Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats". Experimental and Therapeutic Medicine 14.3 (2017): 2536-2542.
Chicago
Liu, J., Mu, S., Zhang, S., Guo, W., Li, Q., Xiao, X., Zhang, J., Wang, Z."Roux‑en‑Y gastric bypass surgery suppresses hypothalamic PTP1B protein level and alleviates leptin resistance in obese rats". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2536-2542. https://doi.org/10.3892/etm.2017.4801
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