Open Access

Polycomb group proteins: Novel molecules associated with ultraviolet A‑induced photoaging of human skin

  • Authors:
    • Zhuoxia Wu
    • Lianbo Zhang
  • View Affiliations

  • Published online on: July 19, 2017     https://doi.org/10.3892/etm.2017.4807
  • Pages: 2554-2562
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long‑wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin fibroblasts (ESFs) in order to simulate photoaging of the skin. The results of cell proliferation, apoptosis, hyaluronic acid (HA) content and reverse transcription-quantitative polymerase chain reaction assays revealed that the expression levels of genes encoding key PcG proteins (BMI‑1 and EZH2) were altered. In addition, the expression levels of these genes were associated with the expression of enzymes that regulate HA synthesis. Furthermore, the expression levels of PcG proteins differed between HSFs and ESFs, suggesting that PcG proteins serve a role in altering HA synthesis during the UVA‑induced fibroblast aging process. This signaling pathway may represent a novel molecular mechanism regulating the photoaging of the skin. The findings of the present study provide important insights into the underlying mechanisms of photoaging of the human skin. Further studies are required to clarify the molecular mechanisms underling skin aging and to identify targets for the clinical treatment of photoaging.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wu Z and Wu Z: Polycomb group proteins: Novel molecules associated with ultraviolet A‑induced photoaging of human skin. Exp Ther Med 14: 2554-2562, 2017
APA
Wu, Z., & Wu, Z. (2017). Polycomb group proteins: Novel molecules associated with ultraviolet A‑induced photoaging of human skin. Experimental and Therapeutic Medicine, 14, 2554-2562. https://doi.org/10.3892/etm.2017.4807
MLA
Wu, Z., Zhang, L."Polycomb group proteins: Novel molecules associated with ultraviolet A‑induced photoaging of human skin". Experimental and Therapeutic Medicine 14.3 (2017): 2554-2562.
Chicago
Wu, Z., Zhang, L."Polycomb group proteins: Novel molecules associated with ultraviolet A‑induced photoaging of human skin". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2554-2562. https://doi.org/10.3892/etm.2017.4807