Open Access

Application of adipose‑derived stromal cells in fat grafting: Basic science and literature review (Review)

  • Authors:
    • Margarita Moustaki
    • Othon Papadopoulos
    • Christos Verikokos
    • Dimitrios Karypidis
    • Dhalia Masud
    • Alkiviadis Kostakis
    • Florentia Papastefanaki
    • Maria G. Roubelakis
    • Despoina Perrea
  • View Affiliations

  • Published online on: July 19, 2017     https://doi.org/10.3892/etm.2017.4811
  • Pages: 2415-2423
  • Copyright: © Moustaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Autologous fat is considered the ideal material for soft‑tissue augmentation in plastic and reconstructive surgery. The primary drawback of autologous fat grafting is the high resorption rate. The isolation of mesenchymal stem cells from adipose tissue inevitably led to research focusing on the study of combined transplantation of autologous fat and adipose derived stem cells (ADSCs) and introduced the theory of ʻcell‑assisted lipotransferʼ. Transplantation of ADSCs is a promising strategy, due to the high proliferative capacity of stem cells, their potential to induce paracrine signalling and ability to differentiate into adipocytes and vascular cells. The current study examined the literature for clinical and experimental studies on cell‑assisted lipotransfer to assess the efficacy of this novel technique when compared with traditional fat grafting. A total of 30 studies were included in the present review. The current study demonstrates that cell‑assisted lipotransfer has improved efficacy compared with conventional fat grafting. Despite relatively positive outcomes, further investigation is required to establish a consensus in cell‑assisted lipotransfer.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Moustaki M, Papadopoulos O, Verikokos C, Karypidis D, Masud D, Kostakis A, Papastefanaki F, Roubelakis MG and Perrea D: Application of adipose‑derived stromal cells in fat grafting: Basic science and literature review (Review). Exp Ther Med 14: 2415-2423, 2017
APA
Moustaki, M., Papadopoulos, O., Verikokos, C., Karypidis, D., Masud, D., Kostakis, A. ... Perrea, D. (2017). Application of adipose‑derived stromal cells in fat grafting: Basic science and literature review (Review). Experimental and Therapeutic Medicine, 14, 2415-2423. https://doi.org/10.3892/etm.2017.4811
MLA
Moustaki, M., Papadopoulos, O., Verikokos, C., Karypidis, D., Masud, D., Kostakis, A., Papastefanaki, F., Roubelakis, M. G., Perrea, D."Application of adipose‑derived stromal cells in fat grafting: Basic science and literature review (Review)". Experimental and Therapeutic Medicine 14.3 (2017): 2415-2423.
Chicago
Moustaki, M., Papadopoulos, O., Verikokos, C., Karypidis, D., Masud, D., Kostakis, A., Papastefanaki, F., Roubelakis, M. G., Perrea, D."Application of adipose‑derived stromal cells in fat grafting: Basic science and literature review (Review)". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2415-2423. https://doi.org/10.3892/etm.2017.4811