Mislocalization of Runt‑related transcription factor 3 results in airway inflammation and airway hyper‑responsiveness in a murine asthma model

Zhou,Xiaoyan; Zhu,Jinxiao; Bian,Tao; Wang,Ruiqian; Gao,Fei

doi:10.3892/etm.2017.4812

September-2017 Volume 14 Issue 3

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September-2017 Volume 14 Issue 3

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Article

Mislocalization of Runt‑related transcription factor 3 results in airway inflammation and airway hyper‑responsiveness in a murine asthma model

Authors:
- Xiaoyan Zhou
- Jinxiao Zhu
- Tao Bian
- Ruiqian Wang
- Fei Gao
View Affiliations / Copyright

Affiliations: Department of Respiratory Medicine, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, P.R. China, Department of Stomatology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China, Department of Respiratory Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China
Pages: 2695-2701
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Published online on: July 19, 2017

https://doi.org/10.3892/etm.2017.4812
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Abstract

The Runt‑related transcription factor (RUNX) gene family consists of three members, RUNX1, ‑2 and ‑3, which heterodimerize with a common protein, core‑binding factor β, and contain the highly conserved Runt‑homology domain. RUNX1 and ‑2 have essential roles in hematopoiesis and osteogenesis. Runx3 protein regulates cell lineage decisions in neurogenesis and thymopoiesis. The aim of the present study was to determine the expression features of the Runx3 protein in a murine asthma model. In vivo, Runx3 protein and mRNA were found to be almost equivalently expressed in the murine lung tissue of the control, ovalbumin (OVA) and genistein groups; however, the nuclear Runx3 protein was abated in lung tissue in OVA‑immunized and challenged mice. Following treatment with genistein, which is a flavonoid previously demonstrated to decrease airway inflammation in asthma, the allergic airway inflammation and airway hyper‑responsiveness were attenuated and the Runx3 protein tended to augment in the nucleus. These results were further determined in vitro. These results indicated that the mislocalization of Runx3 protein is a molecular mechanism of allergic inflammation and airway hyper‑responsiveness in a murine asthma model.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Mislocalization of Runt‑related transcription factor 3 results in airway inflammation and airway hyper‑responsiveness in a murine asthma model

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