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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Astragaloside IV rescues MPP+‑induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A

  • Authors:
    • Yue Liu
    • Li Chong
    • Xiaoqing Li
    • Peng Tang
    • Peng Liu
    • Chen Hou
    • Xin Zhang
    • Rui Li

  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China
  • Pages: 2650-2656
    |
    Published online on: July 25, 2017
       https://doi.org/10.3892/etm.2017.4834
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Abstract

Methionine sulfoxide reductase (Msr) repairs oxidatively damaged proteins through acting as an antioxidant. Oxidative stress has been postulated to cause the mitochondrial dysfunction that is associated with aging and certain diseases, including Parkinson's disease (PD). The present study investigated the protective effects of astragaloside IV (AS‑IV) on 1‑methyl‑4‑phenylpyridinium (MPP+)‑induced mitochondrial dysfunction through MsrA in PC12 cells. This revealed that oxidative stress reduced the expression of MsrA following MPP+ treatment. AS‑IV was demonstrated to protect PC12 cells from MPP+‑induced oxidative damage through upregulating MsrA. MsrA expression was dependent on the Sirt1‑FOXO3a signaling pathway. In addition, knockdown of MsrA reduced the protective effects of AS‑IV, indicating that the antioxidant effects of AS‑UV occurred through MsrA. These results suggest that AS‑IV exerts antioxidant effects and regulates mitochondrial function. Thus, AS‑IV may serve as an effective therapeutic agent for aging and PD.

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Chong L, Li X, Tang P, Liu P, Hou C, Zhang X and Li R: Astragaloside IV rescues MPP+‑induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A. Exp Ther Med 14: 2650-2656, 2017.
APA
Liu, Y., Chong, L., Li, X., Tang, P., Liu, P., Hou, C. ... Li, R. (2017). Astragaloside IV rescues MPP+‑induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A. Experimental and Therapeutic Medicine, 14, 2650-2656. https://doi.org/10.3892/etm.2017.4834
MLA
Liu, Y., Chong, L., Li, X., Tang, P., Liu, P., Hou, C., Zhang, X., Li, R."Astragaloside IV rescues MPP+‑induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A". Experimental and Therapeutic Medicine 14.3 (2017): 2650-2656.
Chicago
Liu, Y., Chong, L., Li, X., Tang, P., Liu, P., Hou, C., Zhang, X., Li, R."Astragaloside IV rescues MPP+‑induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2650-2656. https://doi.org/10.3892/etm.2017.4834
Copy and paste a formatted citation
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Spandidos Publications style
Liu Y, Chong L, Li X, Tang P, Liu P, Hou C, Zhang X and Li R: Astragaloside IV rescues MPP+‑induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A. Exp Ther Med 14: 2650-2656, 2017.
APA
Liu, Y., Chong, L., Li, X., Tang, P., Liu, P., Hou, C. ... Li, R. (2017). Astragaloside IV rescues MPP+‑induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A. Experimental and Therapeutic Medicine, 14, 2650-2656. https://doi.org/10.3892/etm.2017.4834
MLA
Liu, Y., Chong, L., Li, X., Tang, P., Liu, P., Hou, C., Zhang, X., Li, R."Astragaloside IV rescues MPP+‑induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A". Experimental and Therapeutic Medicine 14.3 (2017): 2650-2656.
Chicago
Liu, Y., Chong, L., Li, X., Tang, P., Liu, P., Hou, C., Zhang, X., Li, R."Astragaloside IV rescues MPP+‑induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2650-2656. https://doi.org/10.3892/etm.2017.4834
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