Open Access

Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure

  • Authors:
    • Changbo Liu
    • Mu Li
    • Shixiong Cao
    • Jianzhong Wang
    • Xiaoqiong Huang
    • Weizhen Zhong
  • View Affiliations

  • Published online on: July 27, 2017     https://doi.org/10.3892/etm.2017.4843
  • Pages: 3093-3097
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the study was to investigate the effects of high-volume continuous renal replacement therapy (HV-CRRT) on procalcitonin (PCT), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-8 and IL-10 in acute pancreatitis complicated by acute renal failure. Eighty-six patients with acute pancreatitis complicated with acute renal failure were selected from September 2014 to September 2016 in our hospital, and were treated by continuous veno-venous hemofiltration (CVVH). The patients were randomly divided into the observation group, treated by the HV-CVVH model with a displacement rate of 4 l/h, and the control group, treated by the normal capacity model with a displacement rate of 2 l/h. The levels of PCT, TNF-α, IL-4, IL-6, IL-8, and IL-10 in serum were measured by ELISA before and 2, 6 and 12 h after treatment, and 12 h after CVVH. The serum PCT and TNF-α levels in the two groups were decreased at 2 h after treatment. The lowest levels appeared at 6 h after treatment, and then recovered, but remained lower than those before treatment (p<0.05). The levels of IL-4, IL-6, IL-8 and IL-10, as well as PCT and TNF-α in the two groups were significantly lower than those before treatment, and the decreases in the observation group were more obvious than those in the control group (p<0.05). In conclusion, compared with the standard volume method, HV-CRRT can more effectively remove various inflammatory factors and reduce the levels of serum PCT for the treatment of pancreatitis complicated by acute renal failure. Additionally, replacement of the blood filter at appropriate time-points can improve the treatment efficacy.

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October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu C, Li M, Cao S, Wang J, Huang X and Zhong W: Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure. Exp Ther Med 14: 3093-3097, 2017
APA
Liu, C., Li, M., Cao, S., Wang, J., Huang, X., & Zhong, W. (2017). Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure. Experimental and Therapeutic Medicine, 14, 3093-3097. https://doi.org/10.3892/etm.2017.4843
MLA
Liu, C., Li, M., Cao, S., Wang, J., Huang, X., Zhong, W."Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure". Experimental and Therapeutic Medicine 14.4 (2017): 3093-3097.
Chicago
Liu, C., Li, M., Cao, S., Wang, J., Huang, X., Zhong, W."Effects of HV-CRRT on PCT, TNF-α, IL-4, IL-6, IL-8 and IL-10 in patients with pancreatitis complicated by acute renal failure". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3093-3097. https://doi.org/10.3892/etm.2017.4843