Bax is involved in the anticancer activity of Velcade in colorectal cancer

  • Authors:
    • Liya Su
    • Qimuge Suyila
    • Ling Yang
    • Hong Li
    • Yaguang Xi
    • Xiulan Su
  • View Affiliations

  • Published online on: July 31, 2017     https://doi.org/10.3892/etm.2017.4857
  • Pages: 3179-3183
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Abstract

Numerous chemotherapeutic agents promote tumor cell death by activating the intrinsic apoptosis signaling pathway. This pathway is regulated by mitochondrial dysfunction, which occurs through an intricate process controlled by complex interactions between B‑cell lymphoma 2 (Bcl‑2) family members and other cellular proteins. Bcl‑2‑associated X protein (Bax) is a proapoptotic protein that is an essential component of the intrinsic apoptosis signaling pathway. Patients lacking Bax may be less sensitive to chemotherapy due to an impaired intrinsic apoptosis signaling pathway. The present study demonstrated that Bax expression in colorectal cancer (CRC) tissues was typically increased compared with that in adjacent normal tissues. Furthermore, Bax‑/‑ HCT‑116 cells exhibited reduced proliferation and colony formation ability compared with Bax+/+ HCT116 cells, although the rate of apoptosis of these cells remained unchanged. However, Bax‑/‑ HCT116 cells became more resistant to apoptosis when treated with Velcade. The results of the present study provide novel insights into the relevance of Bax expression to the prognosis of CRC.

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October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Su L, Suyila Q, Yang L, Li H, Xi Y and Su X: Bax is involved in the anticancer activity of Velcade in colorectal cancer. Exp Ther Med 14: 3179-3183, 2017
APA
Su, L., Suyila, Q., Yang, L., Li, H., Xi, Y., & Su, X. (2017). Bax is involved in the anticancer activity of Velcade in colorectal cancer. Experimental and Therapeutic Medicine, 14, 3179-3183. https://doi.org/10.3892/etm.2017.4857
MLA
Su, L., Suyila, Q., Yang, L., Li, H., Xi, Y., Su, X."Bax is involved in the anticancer activity of Velcade in colorectal cancer". Experimental and Therapeutic Medicine 14.4 (2017): 3179-3183.
Chicago
Su, L., Suyila, Q., Yang, L., Li, H., Xi, Y., Su, X."Bax is involved in the anticancer activity of Velcade in colorectal cancer". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3179-3183. https://doi.org/10.3892/etm.2017.4857