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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Bax is involved in the anticancer activity of Velcade in colorectal cancer

  • Authors:
    • Liya Su
    • Qimuge Suyila
    • Ling Yang
    • Hong Li
    • Yaguang Xi
    • Xiulan Su

  • View Affiliations / Copyright

    Affiliations: Clinical Medical Research Center of The Affiliated Hospital, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, P.R. China, Department of Oncology of The Affiliated People's Hospital, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, P.R. China, Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
  • Pages: 3179-3183
    |
    Published online on: July 31, 2017
       https://doi.org/10.3892/etm.2017.4857
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Abstract

Numerous chemotherapeutic agents promote tumor cell death by activating the intrinsic apoptosis signaling pathway. This pathway is regulated by mitochondrial dysfunction, which occurs through an intricate process controlled by complex interactions between B‑cell lymphoma 2 (Bcl‑2) family members and other cellular proteins. Bcl‑2‑associated X protein (Bax) is a proapoptotic protein that is an essential component of the intrinsic apoptosis signaling pathway. Patients lacking Bax may be less sensitive to chemotherapy due to an impaired intrinsic apoptosis signaling pathway. The present study demonstrated that Bax expression in colorectal cancer (CRC) tissues was typically increased compared with that in adjacent normal tissues. Furthermore, Bax‑/‑ HCT‑116 cells exhibited reduced proliferation and colony formation ability compared with Bax+/+ HCT116 cells, although the rate of apoptosis of these cells remained unchanged. However, Bax‑/‑ HCT116 cells became more resistant to apoptosis when treated with Velcade. The results of the present study provide novel insights into the relevance of Bax expression to the prognosis of CRC.

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Copy and paste a formatted citation
Spandidos Publications style
Su L, Suyila Q, Yang L, Li H, Xi Y and Su X: Bax is involved in the anticancer activity of Velcade in colorectal cancer. Exp Ther Med 14: 3179-3183, 2017.
APA
Su, L., Suyila, Q., Yang, L., Li, H., Xi, Y., & Su, X. (2017). Bax is involved in the anticancer activity of Velcade in colorectal cancer. Experimental and Therapeutic Medicine, 14, 3179-3183. https://doi.org/10.3892/etm.2017.4857
MLA
Su, L., Suyila, Q., Yang, L., Li, H., Xi, Y., Su, X."Bax is involved in the anticancer activity of Velcade in colorectal cancer". Experimental and Therapeutic Medicine 14.4 (2017): 3179-3183.
Chicago
Su, L., Suyila, Q., Yang, L., Li, H., Xi, Y., Su, X."Bax is involved in the anticancer activity of Velcade in colorectal cancer". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3179-3183. https://doi.org/10.3892/etm.2017.4857
Copy and paste a formatted citation
x
Spandidos Publications style
Su L, Suyila Q, Yang L, Li H, Xi Y and Su X: Bax is involved in the anticancer activity of Velcade in colorectal cancer. Exp Ther Med 14: 3179-3183, 2017.
APA
Su, L., Suyila, Q., Yang, L., Li, H., Xi, Y., & Su, X. (2017). Bax is involved in the anticancer activity of Velcade in colorectal cancer. Experimental and Therapeutic Medicine, 14, 3179-3183. https://doi.org/10.3892/etm.2017.4857
MLA
Su, L., Suyila, Q., Yang, L., Li, H., Xi, Y., Su, X."Bax is involved in the anticancer activity of Velcade in colorectal cancer". Experimental and Therapeutic Medicine 14.4 (2017): 3179-3183.
Chicago
Su, L., Suyila, Q., Yang, L., Li, H., Xi, Y., Su, X."Bax is involved in the anticancer activity of Velcade in colorectal cancer". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3179-3183. https://doi.org/10.3892/etm.2017.4857
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