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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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International Journal of Molecular Medicine

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article Open Access

Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow

  • Authors:
    • Yue‑Mei Zhang
    • Zhi‑Ming Zhang
    • Quan‑Lin Guan
    • Yong‑Qi Liu
    • Zhi‑Wei Wu
    • Jin‑Tian Li
    • Yun Su
    • Chun‑Lu Yan
    • Ya‑Li Luo
    • Jie Qin
    • Qian Wang
    • Xiao‑Dong Xie

  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Provincial‑Level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Lanzhou, Gansu 730000, P.R. China, Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2983-2991
    |
    Published online on: August 8, 2017
       https://doi.org/10.3892/etm.2017.4909
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Abstract

The initiation and progression of various types of tumors, such as lung neoplasms, are driven by a population of cells with stem cell properties and their microenvironment. Bone marrow mesenchymal stem cells (BM‑MSCs) in long‑term in vitro culture may exhibit spontaneous changes in stem cell biological properties, including malignant transformations; however, the molecular mechanisms of this have not been fully elucidated. In the present study, a BM‑MSC and lung cancer A549 cell co‑culture system was utilized to investigate how the tumor microenvironment may spontaneously change the proliferation, migration and differentiation of BM‑MSCs. It was demonstrated that the lung cancer A549 microenvironment is able to induce changes in the cell morphology, proliferation, karyotype, cytoskeleton and migration ability of BM‑MSCs in vitro. Compared with the control group BM‑MSCs, the expression of Ras, phosphorylated-extracellular regulated protein kinases, nuclear factor‑κB, P62 and B‑cell lymphoma 2 (Bcl‑2) proteins in groups of co‑cultured BM‑MSCs increased significantly (P<0.05) and the expression of P53, Bcl‑2 associated X protein and caspase‑3 protein decreased significantly (P<0.05). The mechanisms responsible for the changes observed in BM‑MSCs may be related to abnormal expression of related genes in the ERK signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang YM, Zhang ZM, Guan QL, Liu YQ, Wu ZW, Li JT, Su Y, Yan CL, Luo YL, Qin J, Qin J, et al: Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow. Exp Ther Med 14: 2983-2991, 2017.
APA
Zhang, Y., Zhang, Z., Guan, Q., Liu, Y., Wu, Z., Li, J. ... Xie, X. (2017). Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow. Experimental and Therapeutic Medicine, 14, 2983-2991. https://doi.org/10.3892/etm.2017.4909
MLA
Zhang, Y., Zhang, Z., Guan, Q., Liu, Y., Wu, Z., Li, J., Su, Y., Yan, C., Luo, Y., Qin, J., Wang, Q., Xie, X."Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow". Experimental and Therapeutic Medicine 14.4 (2017): 2983-2991.
Chicago
Zhang, Y., Zhang, Z., Guan, Q., Liu, Y., Wu, Z., Li, J., Su, Y., Yan, C., Luo, Y., Qin, J., Wang, Q., Xie, X."Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow". Experimental and Therapeutic Medicine 14, no. 4 (2017): 2983-2991. https://doi.org/10.3892/etm.2017.4909
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang YM, Zhang ZM, Guan QL, Liu YQ, Wu ZW, Li JT, Su Y, Yan CL, Luo YL, Qin J, Qin J, et al: Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow. Exp Ther Med 14: 2983-2991, 2017.
APA
Zhang, Y., Zhang, Z., Guan, Q., Liu, Y., Wu, Z., Li, J. ... Xie, X. (2017). Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow. Experimental and Therapeutic Medicine, 14, 2983-2991. https://doi.org/10.3892/etm.2017.4909
MLA
Zhang, Y., Zhang, Z., Guan, Q., Liu, Y., Wu, Z., Li, J., Su, Y., Yan, C., Luo, Y., Qin, J., Wang, Q., Xie, X."Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow". Experimental and Therapeutic Medicine 14.4 (2017): 2983-2991.
Chicago
Zhang, Y., Zhang, Z., Guan, Q., Liu, Y., Wu, Z., Li, J., Su, Y., Yan, C., Luo, Y., Qin, J., Wang, Q., Xie, X."Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow". Experimental and Therapeutic Medicine 14, no. 4 (2017): 2983-2991. https://doi.org/10.3892/etm.2017.4909
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