CD19+CD24hiCD38hi regulatory B cells are associated with insulin resistance in type I Hashimoto's thyroiditis in Chinese females

  • Authors:
    • Min Yang
    • Changji Du
    • Yinping Wang
    • Jun Liu
  • View Affiliations

  • Published online on: August 14, 2017     https://doi.org/10.3892/etm.2017.4925
  • Pages: 3887-3893
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Abstract

Hashimoto's thyroiditis (HT) is typically associated with insulin resistance. The aim of the present study was to investigate the role of regulatory B cells (Bregs) in insulin resistance in patients with HT. A total of 52 female patients with type I HT and 35 matched healthy volunteers were enrolled. Demographic and laboratorial data were collected. A 75 g oral glucose tolerance test was performed on each subject. Flow cytometry was performed to evaluate the levels of CD19+CD24hiCD38hi Bregs in peripheral blood. Patients with HT exhibited significantly higher postprandial insulin levels (P<0.01), but normal glucose levels. The level of CD19+CD24hiCD38hi Bregs in patients with HT decreased significantly (P=0.0002) compared with the controls. Pearson's linear correlation model revealed a significant, negative association between anti‑thyroid peroxidase antibodies (TPOAb) and homeostasis model assessment of β cell (r=‑0.313, P=0.014). The same correlation model revealed a significant, negative association between TPOAb and the disposition index (DI; r=‑0.305, P=0.017), and between anti‑thyroglobulin antibodies and DI (r=‑0.321, P=0.013). Patients with a decreased ratio of CD19+CD24hiCD38hi Bregs to CD19+ lymphocytes exhibited higher levels of total cholesterol and low‑density lipoprotein cholesterol. A decrease in the ratio of CD19+CD24hiCD38hi Bregs to lymphocytes was a significant independent risk factor for hyperinsulinemia (odds ratio=1.372, P=0.035). A decrease in peripheral blood CD19+CD24hiCD38hi Bregs is associated with insulin resistance in HT patients, and was an independent risk factor for postprandial hyperinsulinemia. The present study provided a novel insight into the development of effective therapeutic strategies targeting immune mechanisms associated with HT.

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October-2017
Volume 14 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang M, Du C, Wang Y and Liu J: CD19+CD24hiCD38hi regulatory B cells are associated with insulin resistance in type I Hashimoto's thyroiditis in Chinese females. Exp Ther Med 14: 3887-3893, 2017.
APA
Yang, M., Du, C., Wang, Y., & Liu, J. (2017). CD19+CD24hiCD38hi regulatory B cells are associated with insulin resistance in type I Hashimoto's thyroiditis in Chinese females. Experimental and Therapeutic Medicine, 14, 3887-3893. https://doi.org/10.3892/etm.2017.4925
MLA
Yang, M., Du, C., Wang, Y., Liu, J."CD19+CD24hiCD38hi regulatory B cells are associated with insulin resistance in type I Hashimoto's thyroiditis in Chinese females". Experimental and Therapeutic Medicine 14.4 (2017): 3887-3893.
Chicago
Yang, M., Du, C., Wang, Y., Liu, J."CD19+CD24hiCD38hi regulatory B cells are associated with insulin resistance in type I Hashimoto's thyroiditis in Chinese females". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3887-3893. https://doi.org/10.3892/etm.2017.4925