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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article Open Access

Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression

  • Authors:
    • Zhaorong Chen
    • Aling Shen
    • Liya Liu
    • Youqin Chen
    • Jianfeng Chu
    • Qiaoyan Cai
    • Fei Qi
    • Thomas Joseph Sferra
    • Jun Peng

  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3533-3540
    |
    Published online on: August 16, 2017
       https://doi.org/10.3892/etm.2017.4951
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Abstract

The well‑known traditional Chinese medicine formula Pien Tze Huang (PZH) has long been used to treat various malignancies, including colorectal cancer (CRC). It was recently reported that PZH possesses the ability to overcome multidrug resistance in CRC cells. In the present study, a 5‑fluorouracil (5‑FU) resistant human CRC cell line (HCT‑8/5‑FU) was used to further evaluate the effect of PZH on chemotherapy (chemo)‑resistance and investigate the mechanisms through which this occurs. The results identified that PZH significantly reduced the viability and cell density of HCT‑8/5‑FU cells in a dose‑ and time‑dependent manner (P<0.05). PZH inhibited cell survival, reduced the proportion of cells in S‑phase, and suppressed the expression of pro‑proliferative proteins cyclin D1 and cyclin‑dependent kinase 4. In addition, PZH treatment induced nuclear condensation and fragmentation, activated caspase‑9 and ‑3 and increased the pro‑apoptotic Bcl‑2‑associated X protein/B‑cell lymphoma 2 protein ratio. Furthermore, PZH treatment upregulated the expression of microRNA-22 (miR‑22) and downregulated the expression of c‑Myc (a target gene of miR‑22). In conclusion, the findings from the present study suggest that PZH can overcome chemo‑resistance in cancer cells, likely through increasing miR‑22 expression, and by reversing the imbalance between levels of proliferation and apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Chen Z, Shen A, Liu L, Chen Y, Chu J, Cai Q, Qi F, Sferra TJ and Peng J: Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression. Exp Ther Med 14: 3533-3540, 2017.
APA
Chen, Z., Shen, A., Liu, L., Chen, Y., Chu, J., Cai, Q. ... Peng, J. (2017). Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression. Experimental and Therapeutic Medicine, 14, 3533-3540. https://doi.org/10.3892/etm.2017.4951
MLA
Chen, Z., Shen, A., Liu, L., Chen, Y., Chu, J., Cai, Q., Qi, F., Sferra, T. J., Peng, J."Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression". Experimental and Therapeutic Medicine 14.4 (2017): 3533-3540.
Chicago
Chen, Z., Shen, A., Liu, L., Chen, Y., Chu, J., Cai, Q., Qi, F., Sferra, T. J., Peng, J."Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3533-3540. https://doi.org/10.3892/etm.2017.4951
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Z, Shen A, Liu L, Chen Y, Chu J, Cai Q, Qi F, Sferra TJ and Peng J: Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression. Exp Ther Med 14: 3533-3540, 2017.
APA
Chen, Z., Shen, A., Liu, L., Chen, Y., Chu, J., Cai, Q. ... Peng, J. (2017). Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression. Experimental and Therapeutic Medicine, 14, 3533-3540. https://doi.org/10.3892/etm.2017.4951
MLA
Chen, Z., Shen, A., Liu, L., Chen, Y., Chu, J., Cai, Q., Qi, F., Sferra, T. J., Peng, J."Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression". Experimental and Therapeutic Medicine 14.4 (2017): 3533-3540.
Chicago
Chen, Z., Shen, A., Liu, L., Chen, Y., Chu, J., Cai, Q., Qi, F., Sferra, T. J., Peng, J."Pien Tze Huang induces apoptosis and inhibits proliferation of 5-fluorouracil-resistant colorectal carcinoma cells via increasing miR-22 expression". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3533-3540. https://doi.org/10.3892/etm.2017.4951
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