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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Sophocarpine against enterovirus 71 in vitro

  • Authors:
    • Zengjun Jin
    • Lixin Yang
    • Guotao Ding
    • Guoxing Yang
    • Yonghong Han
    • Xia Zhang
    • Weihao Li

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China, Hebei Centre for Disease Control and Prevention, Shijiazhuang, Hebei 050021, P.R. China, Handan Municipal Centre for Disease Control and Prevention, Handan, Hebei 056008, P.R. China, School of Life Science and Technology, Tongji University, Shanghai 200092, P.R. China
  • Pages: 3792-3797
    |
    Published online on: August 17, 2017
       https://doi.org/10.3892/etm.2017.4958
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Abstract

Sophocarpine (SCA) is a bioactive alkaloid present in Sophoraflavescens Ait. The present study demonstrated that SCA inhibited enterovirus 71 (EV71) infection in Vero cells. The results indicated that the 50% cytotoxicity concentration of SCA for Vero cells was 1,346 µg/ml, and the 50% inhibition concentration of SCA against EV71 was 350 µg/ml. SCA produced a marked inhibitory effect against EV71 when the Vero cells were treated with SCA prior to infection with the virus. Additionally, SCA was effective against EV71 when the Vero cells were infected with EV71 (100xTCID50) that had been treated with SCA for 2 h, and was effective when the Vero cells were infected with EV71 (100xTCID50) at 37˚C under 5% CO2 for 2 h prior to treatment with SCA for 2 h. SCA was demonstrated to inhibit the attachment and penetration of EV71 and was more effective at inhibiting attachment. The assay additionally verified that SCA suppressed the replication of viral genomic RNA and indicated that SCA may inhibit EV71 infection in vitro.

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Copy and paste a formatted citation
Spandidos Publications style
Jin Z, Yang L, Ding G, Yang G, Han Y, Zhang X and Li W: Sophocarpine against enterovirus 71 in vitro. Exp Ther Med 14: 3792-3797, 2017.
APA
Jin, Z., Yang, L., Ding, G., Yang, G., Han, Y., Zhang, X., & Li, W. (2017). Sophocarpine against enterovirus 71 in vitro. Experimental and Therapeutic Medicine, 14, 3792-3797. https://doi.org/10.3892/etm.2017.4958
MLA
Jin, Z., Yang, L., Ding, G., Yang, G., Han, Y., Zhang, X., Li, W."Sophocarpine against enterovirus 71 in vitro". Experimental and Therapeutic Medicine 14.4 (2017): 3792-3797.
Chicago
Jin, Z., Yang, L., Ding, G., Yang, G., Han, Y., Zhang, X., Li, W."Sophocarpine against enterovirus 71 in vitro". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3792-3797. https://doi.org/10.3892/etm.2017.4958
Copy and paste a formatted citation
x
Spandidos Publications style
Jin Z, Yang L, Ding G, Yang G, Han Y, Zhang X and Li W: Sophocarpine against enterovirus 71 in vitro. Exp Ther Med 14: 3792-3797, 2017.
APA
Jin, Z., Yang, L., Ding, G., Yang, G., Han, Y., Zhang, X., & Li, W. (2017). Sophocarpine against enterovirus 71 in vitro. Experimental and Therapeutic Medicine, 14, 3792-3797. https://doi.org/10.3892/etm.2017.4958
MLA
Jin, Z., Yang, L., Ding, G., Yang, G., Han, Y., Zhang, X., Li, W."Sophocarpine against enterovirus 71 in vitro". Experimental and Therapeutic Medicine 14.4 (2017): 3792-3797.
Chicago
Jin, Z., Yang, L., Ding, G., Yang, G., Han, Y., Zhang, X., Li, W."Sophocarpine against enterovirus 71 in vitro". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3792-3797. https://doi.org/10.3892/etm.2017.4958
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