MicroRNA‑206 inhibits the viability and migration of medulloblastoma cells by targeting LIM and SH3 protein 1

MicroRNA (miR)‑206 has been found to be deregulated in various types of human cancer, including medulloblastoma. However, the regulatory mechanism of miR‑206 in medulloblastoma growth and metastasis remains largely unclear. In the present study, reverse transcription‑quantitative polymerase chain reaction data indicated that miR‑206 was significantly downregulated in medulloblastoma tissues compared with adjacent non‑tumor tissues (P<0.01). Furthermore, low expression of miR‑206 was significantly associated with seeding at presentation and anaplastic histology (P<0.01), but not with sex, age, or residual tumors. Overexpression of miR‑206 significantly reduced the viability and migration of medulloblastoma D341 cells (P<0.01). LIM and SH3 protein 1 (LASP1) was further identified as a novel target of miR‑206 in D341 cells. mRNA levels of LASP1 were significantly higher in medulloblastoma tissues compared to adjacent non‑tumor tissues (P<0.01), with an inverse correlation to the miR‑206 levels in medulloblastoma tissues. In addition, protein expression levels of LASP1 ere negatively regulated by miR‑206 in D341 cells. Further investigation showed that overexpression of LASP1 significantly eliminated the inhibitory effects of miR‑206 on the migration and invasion of D341 cells (P<0.01). In conclusion, our study demonstrates that miR‑206 has a suppressive role in medulloblastoma cell viability and invasion, partly at least, via the targeting of LASP1. Our study highlights the importance of the miR‑206/LASP1 in medulloblastoma.