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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article Open Access

The long non‑coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma

  • Authors:
    • Bailiang Ye
    • Bingren Hu
    • Zhihai Zheng
    • Ru Zheng
    • Yixiong Shi

  • View Affiliations / Copyright

    Affiliations: Department of Laparoscopic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3658-3664
    |
    Published online on: August 24, 2017
       https://doi.org/10.3892/etm.2017.5019
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Abstract

The long non‑coding RNAs (lncRNAs) have been demonstrated to play pivotal roles in a broad range of processes including tumor biology. However, the exact contributions of lncRNAs to hepatocellular carcinoma (HCC) remain poorly defined. In current study, we have unraveled a novel function of AK023948 in HCC. We found that AK023948 was substantially upregulated in tumor tissues. Meanwhile, higher AK023948 expression correlated with poor survival. Upregulation of AK023948 expression can promote HepG2 and Hep3B proliferation and invasion in in vitro experiments. Furthermore, AK023948 also decreased tumor growth in vivo. The tumorigenic role of AK023948 was partially ascribed to PI3K/Akt/mTOR signaling and AK023948 knockdown decreased pathway activation and tumor growth. These data collectively suggest an oncogenic role for AK023948 and may provide potential insight into therapeutic intervention.

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Copy and paste a formatted citation
Spandidos Publications style
Ye B, Hu B, Zheng Z, Zheng R and Shi Y: The long non‑coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma. Exp Ther Med 14: 3658-3664, 2017.
APA
Ye, B., Hu, B., Zheng, Z., Zheng, R., & Shi, Y. (2017). The long non‑coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma. Experimental and Therapeutic Medicine, 14, 3658-3664. https://doi.org/10.3892/etm.2017.5019
MLA
Ye, B., Hu, B., Zheng, Z., Zheng, R., Shi, Y."The long non‑coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma". Experimental and Therapeutic Medicine 14.4 (2017): 3658-3664.
Chicago
Ye, B., Hu, B., Zheng, Z., Zheng, R., Shi, Y."The long non‑coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3658-3664. https://doi.org/10.3892/etm.2017.5019
Copy and paste a formatted citation
x
Spandidos Publications style
Ye B, Hu B, Zheng Z, Zheng R and Shi Y: The long non‑coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma. Exp Ther Med 14: 3658-3664, 2017.
APA
Ye, B., Hu, B., Zheng, Z., Zheng, R., & Shi, Y. (2017). The long non‑coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma. Experimental and Therapeutic Medicine, 14, 3658-3664. https://doi.org/10.3892/etm.2017.5019
MLA
Ye, B., Hu, B., Zheng, Z., Zheng, R., Shi, Y."The long non‑coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma". Experimental and Therapeutic Medicine 14.4 (2017): 3658-3664.
Chicago
Ye, B., Hu, B., Zheng, Z., Zheng, R., Shi, Y."The long non‑coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3658-3664. https://doi.org/10.3892/etm.2017.5019
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