Vascular corrosion casting of normal and pre‑eclamptic placentas

Yin,Geping; Chen,Ming; Li,Juan; Zhao,Xiaoli; Yang,Shujun; Li,Xiuyun; Yuan,Zheng; Wu,Aifang

doi:10.3892/etm.2017.5207

December-2017 Volume 14 Issue 6

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December-2017 Volume 14 Issue 6

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Article

Vascular corrosion casting of normal and pre‑eclamptic placentas

Authors:
- Geping Yin
- Ming Chen
- Juan Li
- Xiaoli Zhao
- Shujun Yang
- Xiuyun Li
- Zheng Yuan
- Aifang Wu
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Jinan Military General Hospital, Jinan, Shandong 250031, P.R. China
Pages: 5535-5539
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Published online on: September 27, 2017

https://doi.org/10.3892/etm.2017.5207
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Abstract

Pre‑eclampsia is an important cause of maternal and fetal morbidity and mortality that is associated with decreased placental perfusion. In the present study, vascular corrosion casting was used to investigate the differences in structural changes of the fetoplacental vasculature between normal and pre‑eclamptic placentas. An improved epoxy resin vascular casting technique was used in the present study. Casting media were infused into 40 normal and 40 pre‑eclamptic placentas through umbilical arteries and veins in order to construct three dimensional fetoplacental vasculatures. The number of branches, diameter, morphology and peripheral artery‑to‑vein ratio were measured for each specimen. The results indicated that the venous system of normal placentas was divided into 5‑7 grades of branches and the volume of the vascular bed was 155.5±45.3 ml. In severe pre‑eclamptic placentas, the volume was 106.4±36.1 ml, which was significantly lower compared with normal placentas (P<0.01). The venous system of pre‑eclamptic placentas was divided into 4‑5 grades of branches, which was much more sparse compared with normal placentas. In additions, the diameters of grade 1‑3 veins and grade 2‑3 arteries were significantly smaller in severe pre‑eclampsia (P<0.05). In conclusion, pre‑eclamptic placentas displayed a decreased volume of vascular bed, smaller diameters of grade 1‑3 veins and grade 2‑3 arteries, and an increased peripheral artery‑to‑vein ratio, which may be a cause of the placental dysfunction during severe pre‑eclampsia.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Vascular corrosion casting of normal and pre‑eclamptic placentas

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