Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Treatment of acute intermittent porphyria during pregnancy and posterior reversible encephalopathy syndrome after delivery: A case report

  • Authors:
    • Jian Zhang
    • Yiting Hu
    • Jimin Zheng
    • Juncha Gao
    • Hongtao Hou
    • Na Liu
    • Yuzhen Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China
  • Pages: 5554-5556
    |
    Published online on: September 27, 2017
       https://doi.org/10.3892/etm.2017.5212
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute intermittent porphyria (AIP) is a rare inherited disorder of heme metabolism. It has the ability to trigger posterior reversible encephalopathy syndrome (PRES), a rare acute neurologic condition that is characterized by acute neurological symptoms. Pregnancy may induce AIP attacks. The present report describes the case of a pregnant woman with AIP. The patient was treated with heme‑arginate during pregnancy and successfully delivered a healthy baby. Following delivery, the patient presented with PRES and experienced generalized seizures. Treatment including arginine hemoglobin, calcium gluconate and sodium chloride was administered. The symptoms of epilepsy did not recur. Magnetic resonance imaging of the head demonstrated that the bilateral occipital lobe lesions were significantly reduced in size following the treatment. In the present report, it was demonstrated that administration of heme‑arginate for AIP during pregnancy is safe. Timely administration of arginine hemoglobin, calcium gluconate and sodium chloride may more efficiently improve the clinical status in AIP patients diagnosed with PRES who experience generalized seizures.
View Figures

Figure 1

View References

1 

Aggarwal N, Bagga R, Sawhney H, Suri V and Vasishta K: Pregnancy with acute intermittent porphyria: A case report and review of literature. J Obstet Gynaecol Res. 28:160–162. 2002. View Article : Google Scholar : PubMed/NCBI

2 

González-Arriaza HL and Bostwick JM: Acute porphyrias: A case report and review. Am J Psychiatry. 160:450–459. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Takata T, Kume K, Kokudo Y, Ikeda K, Kamada M, Touge T, Deguchi K and Masaki T: Acute intermittent porphyria presenting with posterior reversible encephalopathy syndrome, accompanied by prolonged vasoconstriction. Intern Med. 56:713–717. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Kantor G and Rolbin SH: Acute intermittent porphyria and caesarean delivery. Can J Anaesth. 39:282–285. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Farfaras A, Zagouri F, Zografos G, Kostopoulou A, Sergentanis TN and Antoniou S: Acute intermittent porphyria in pregnancy: A common misdiagnosis. Clin Exp Obstet Gynecol. 37:256–260. 2010.PubMed/NCBI

6 

Patil SV, Dhamangaonkar BR, Pattanshetti RC and Patil MM: Posterior reversible encephalopathy syndrome in early postpartum women: A case report. J Clin Diagn Res. 8:RD01–RD02. 2014.PubMed/NCBI

7 

Wen Y, Yang B, Huang Q and Liu Y: Posterior reversible encephalopathy syndrome in pregnancy: A retrospective series of 36 patients from mainland China. Ir J Med Sci. Feb 2–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

8 

Kanaan C, Veille JC and Lakin M: Pregnancy and acute intermittent porphyria. Obstet Gynecol Surv. 44:244–249. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Anderson KE, Bloomer JR, Bonkovsky HL, Kushner JP, Pierach CA, Pimstone NR and Desnick RJ: Recommendations for the diagnosis and treatment of the acute porphyrias. Ann Intern Med. 142:439–450. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Armen TA, Sai-Sudhakar CB, Blais D and Awad H: Anesthetic management for combined double-valve and coronary artery bypass in a patient with acute intermittent porphyria. J Cardiothorac Vasc Anesth. 23:364–368. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Isenschmid M, König C, Fässli C, Haenel A, Hänggi W and Schneider H: Acute intermittent porphyria in pregnancy: Glucose or hematin therapy? Schweiz Med Wochenschr. 122:1741–1745. 1992.(In German). PubMed/NCBI

12 

Engelhardt K, Trinka E, Franz G, Unterberger I, Spiegel M, Beer R, Pfausler B, Kampfl A and Schmutzhard E: Refractory status epilepticus due to acute hepatic porphyria in a pregnant woman: Induced abortion as the sole therapeutic option? Eur J Neurol. 11:693–697. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Sahu MT, Rajaram S, Saxena AK, Goel N and Ghumman S: Medical termination of pregnancy in acute intermittent porphyria. Gynecol Obstet Invest. 62:38–40. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Weinzierl A, Brezinka C and Engelhardt K: Unusual manifestation of acute hepatic porphyria in pregnancy. Fetal Diagn Ther. 22:136–138. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Lee VH, Wijdicks EF, Manno EM and Rabinstein AA: Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol. 65:205–210. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Casey SO, Sampaio RC, Michel E and Truwit CL: Posterior reversible encephalopathy syndrome: Utility of fluid-attenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions. AJNR Am J Neuroradiol. 21:1199–1206. 2000.PubMed/NCBI

17 

Tarim E and Giray S: Posterior reversible encephalopathy syndrome (PRES) in the differential diagnosis of eclampsia: Case report. Turkiye Klinikleri J Gynecol Obs. 21:213–215. 2011.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Hu Y, Zheng J, Gao J, Hou H, Liu N and Wang Y: Treatment of acute intermittent porphyria during pregnancy and posterior reversible encephalopathy syndrome after delivery: A case report. Exp Ther Med 14: 5554-5556, 2017.
APA
Zhang, J., Hu, Y., Zheng, J., Gao, J., Hou, H., Liu, N., & Wang, Y. (2017). Treatment of acute intermittent porphyria during pregnancy and posterior reversible encephalopathy syndrome after delivery: A case report. Experimental and Therapeutic Medicine, 14, 5554-5556. https://doi.org/10.3892/etm.2017.5212
MLA
Zhang, J., Hu, Y., Zheng, J., Gao, J., Hou, H., Liu, N., Wang, Y."Treatment of acute intermittent porphyria during pregnancy and posterior reversible encephalopathy syndrome after delivery: A case report". Experimental and Therapeutic Medicine 14.6 (2017): 5554-5556.
Chicago
Zhang, J., Hu, Y., Zheng, J., Gao, J., Hou, H., Liu, N., Wang, Y."Treatment of acute intermittent porphyria during pregnancy and posterior reversible encephalopathy syndrome after delivery: A case report". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5554-5556. https://doi.org/10.3892/etm.2017.5212
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Hu Y, Zheng J, Gao J, Hou H, Liu N and Wang Y: Treatment of acute intermittent porphyria during pregnancy and posterior reversible encephalopathy syndrome after delivery: A case report. Exp Ther Med 14: 5554-5556, 2017.
APA
Zhang, J., Hu, Y., Zheng, J., Gao, J., Hou, H., Liu, N., & Wang, Y. (2017). Treatment of acute intermittent porphyria during pregnancy and posterior reversible encephalopathy syndrome after delivery: A case report. Experimental and Therapeutic Medicine, 14, 5554-5556. https://doi.org/10.3892/etm.2017.5212
MLA
Zhang, J., Hu, Y., Zheng, J., Gao, J., Hou, H., Liu, N., Wang, Y."Treatment of acute intermittent porphyria during pregnancy and posterior reversible encephalopathy syndrome after delivery: A case report". Experimental and Therapeutic Medicine 14.6 (2017): 5554-5556.
Chicago
Zhang, J., Hu, Y., Zheng, J., Gao, J., Hou, H., Liu, N., Wang, Y."Treatment of acute intermittent porphyria during pregnancy and posterior reversible encephalopathy syndrome after delivery: A case report". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5554-5556. https://doi.org/10.3892/etm.2017.5212
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team