Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice

  • Authors:
    • Xiaolin Zhao
    • Peng Liang
    • Jin Liu
    • Haixia Jiang
    • Xiaoshuai Fan
    • Guo Chen
    • Cheng Zhou
  • View Affiliations / Copyright

    Affiliations: Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 5664-5670
    |
    Published online on: September 29, 2017
       https://doi.org/10.3892/etm.2017.5222
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The endocannabinoid system (ECS) is a potential pharmaceutical target for the treatment of inflammatory bowel diseases (IBDs). The aim of this study was to explore the effects of activation of the ECS on IBD and the associated neural inflammation‑induced disruption of the blood‑brain barrier (BBB). In a mouse model of trinitrobenzene sulfonic acid‑induced colitis, the inhibition of fatty acid amide hydrolase with URB597 elevated the arachidonoylethanolamide concentration of the colon. Macroscopic alterations of the colons were evaluated, and the 7‑day survival rate of mice was analyzed. BBB integrity was assessed using a dye tracer method, and the cognitive function of mice was examined using a fear‑conditioning test. URB597 treatment significantly reduced macroscopic alterations of the colon, decreased the mortality rate, and protected the integrity of the BBB in the mice (P<0.05). No significant changes were observed in the cognitive functions of the mice (P>0.05); therefore, the neuroprotective effect of ECS in this colitis model requires further investigation. Activation of the ECS was efficient in ameliorating colitis and increasing the survival rate of the mice, and reducing remote organ changes induced by colitis. The results suggest that modulation of the ECS is a potential therapeutic approach for IBDs and the associated remote organ lesions.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Di Marzo V, Bifulco M and de Petrocellis: The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov. 3:771–784. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Piomelli D, Giuffrida A, Calignano A and de Fonseca Rodríguez F: The endocannabinoid system as a target for therapeutic drugs. Trends Pharmacol Sci. 21:218–224. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Pertwee RG: Targeting the endocannabinoid system with cannabinoid receptor agonists: Pharmacological strategies and therapeutic possibilities. Philos Trans R Soc Lond B Biol Sci. 367:3353–3363. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Di Marzo V: The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacol Res. 60:77–84. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Maccarrone M, Bari M, Battista N and Finazzi-Agrò A: Endocannabinoid degradation, endotoxic shock and inflammation. Curr Drug Targets Inflamm Allergy. 1:53–63. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Di Marzo V and Piscitelli F: Gut feelings about the endocannabinoid system. Neurogastroenterol Motil. 23:391–398. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Alhouayek M and Muccioli GG: The endocannabinoid system in inflammatory bowel diseases: From pathophysiology to therapeutic opportunity. Trends Mol Med. 18:615–625. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Nasser Y, Bashashati M and Andrews CN: Toward modulation of the endocannabinoid system for treatment of gastrointestinal disease: FAAHster but not ‘higher’. Neurogastroenterol Motil. 26:447–454. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Izzo AA and Sharkey KA: Cannabinoids and the gut: New developments and emerging concepts. Pharmacol Ther. 126:21–38. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Ravikoff Allegretti J, Courtwright A, Lucci M, Korzenik JR and Levine J: Marijuana use patterns among patients with inflammatory bowel disease. Inflamm Bowel Dis. 19:2809–2814. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Engel MA, Kellermann CA, Burnat G, Hahn EG, Rau T and Konturek PC: Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis. J Physiol Pharmacol. 61:89–97. 2010.PubMed/NCBI

12 

Alhouayek M, Lambert DM, Delzenne NM, Cani PD and Muccioli GG: Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. FASEB J. 25:2711–2721. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Storr MA, Keenan CM, Emmerdinger D, Zhang H, Yüce B, Sibaev A, Massa F, Buckley NE, Lutz B, Göke B, et al: Targeting endocannabinoid degradation protects against experimental colitis in mice: Involvement of CB1 and CB2 receptors. J Mol Med (Berl). 86:925–936. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Downer EJ: Cannabinoids and innate immunity: Taking a toll on neuroinflammation. ScientificWorldJournal. 11:855–865. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Fishbein-Kaminietsky M, Gafni M and Sarne Y: Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage. J Neurosci Res. 92:1669–1677. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Sardinha J, Kelly ME, Zhou J and Lehmann C: Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm. 2014:9786782014. View Article : Google Scholar : PubMed/NCBI

17 

Dowie MJ, Howard ML, Nicholson LF, Faull RL, Hannan AJ and Glass M: Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice. Neuroscience. 170:324–336. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA and Lynch MA: The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation. J Neuroinflammation. 9:792012. View Article : Google Scholar : PubMed/NCBI

19 

Henry RJ, Kerr DM, Finn DP and Roche M: FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus. J Neuroimmunol. 276:126–134. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Katz PS, Sulzer JK, Impastato RA, Teng SX, Rogers EK and Molina PE: Endocannabinoid degradation inhibition improves neurobehavioral function, blood brain barrier integrity, and neuroinflammation following mild traumatic brain injury. J Neurotrauma. 32:297–306. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Fichna J, Dicay M, Lewellyn K, Janecka A, Zjawiony JK, MacNaughton WK and Storr MA: Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors. Inflamm Bowel Dis. 18:1137–1145. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Wirtz S and Neurath MF: Mouse models of inflammatory bowel disease. Adv Drug Deliv Rev. 59:1073–1083. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Shoji H, Takao K, Hattori S and Miyakawa T: Contextual and cued fear conditioning test using a video analyzing system in mice. J Vis Exp. 85:e508712014.doi: 10.3791/50871.

24 

Lomazzo E, Bindila L, Remmers F, Lerner R, Schwitter C, Hoheisel U and Lutz B: Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. Neuropsychopharmacology. 40:488–501. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Vendel E and de Lange EC: Functions of the CB1 and CB 2 receptors in neuroprotection at the level of the blood-brain barrier. Neuromolecular Med. 16:620–642. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Liang P, Liu J, Jiang H, Fan X, Chen G and Zhou C: Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice. Exp Ther Med 14: 5664-5670, 2017.
APA
Zhao, X., Liang, P., Liu, J., Jiang, H., Fan, X., Chen, G., & Zhou, C. (2017). Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice. Experimental and Therapeutic Medicine, 14, 5664-5670. https://doi.org/10.3892/etm.2017.5222
MLA
Zhao, X., Liang, P., Liu, J., Jiang, H., Fan, X., Chen, G., Zhou, C."Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice". Experimental and Therapeutic Medicine 14.6 (2017): 5664-5670.
Chicago
Zhao, X., Liang, P., Liu, J., Jiang, H., Fan, X., Chen, G., Zhou, C."Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5664-5670. https://doi.org/10.3892/etm.2017.5222
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Liang P, Liu J, Jiang H, Fan X, Chen G and Zhou C: Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice. Exp Ther Med 14: 5664-5670, 2017.
APA
Zhao, X., Liang, P., Liu, J., Jiang, H., Fan, X., Chen, G., & Zhou, C. (2017). Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice. Experimental and Therapeutic Medicine, 14, 5664-5670. https://doi.org/10.3892/etm.2017.5222
MLA
Zhao, X., Liang, P., Liu, J., Jiang, H., Fan, X., Chen, G., Zhou, C."Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice". Experimental and Therapeutic Medicine 14.6 (2017): 5664-5670.
Chicago
Zhao, X., Liang, P., Liu, J., Jiang, H., Fan, X., Chen, G., Zhou, C."Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5664-5670. https://doi.org/10.3892/etm.2017.5222
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team