Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus

  • Authors:
    • Yanxin Shen
    • Huiling Xu
    • Xiaoyuan Pan
    • Weijiang Wu
    • Hui Wang
    • Linlin Yan
    • Miaomiao Zhang
    • Xia Liu
    • Sheng Xia
    • Qixiang Shao
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Second People's Hospital of Taicang, Taicang, Jiangsu 215400, P.R. China, Department of Immunology, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China
  • Pages: 5589-5596
    |
    Published online on: October 3, 2017
       https://doi.org/10.3892/etm.2017.5254
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Type 2 diabetes mellitus (T2DM) is a leading cause of blindness, non‑traumatic amputation and end‑stage renal disease, as well as a major cardiovascular risk factor. To determine whether miR‑125b and miR‑34a serve an important role in the development of T2DM, the current study investigated the expression profile of two microRNAs (miR‑34a and miR‑125b) and their relative genes in peripheral blood mononuclear cells from 73 patients with T2DM and 52 healthy donors by reverse transcription‑quantitative polymerase chain reaction In addition, the association between miR‑34a, miR‑125b and their relevant genes expression profile were analyzed with respect to the pathogenesis of T2DM. The present study demonstrated that the expression levels of miR‑125b and miR‑34a were elevated in peripheral blood mononuclear cell samples from patients with T2DM. Furthermore, miR‑34a and miR‑125b were positively correlated with low‑density lipoprotein/high‑density lipoprotein (HDL) and Foxp3 and negatively related to triglyceride/HDL. However, no correlation among miR‑34a, miR‑125b and the value of homeostasis model assessment of insulin resistance, homeostasis model assessment of β‑cell function and the genes of B lymphocyte‑induced maturation protein‑1, interferon regulatory factor‑4, P53 and retinoid‑related orphan receptor γt were observed. These results indicate that the alteration of miR‑34a and miR‑125b exists in patients with T2DM, which may be involved in the pathogenesis of T2DM, and could be a potential novel biomarker of T2DM.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Kommoju UJ, Maruda J, Kadarkarai Samy S, Irgam K, Kotla JP and Reddy BM: Association of IRS1, CAPN10, and PPARG gene polymorphisms with type 2 diabetes mellitus in the high-risk population of Hyderabad, India. J Diabetes. 6:564–573. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Yang X, Deng Y, Gu H, Ren X, Li N, Lim A, Snellingen T, Liu X, Wang N and Liu N: Candidate gene association study for diabetic retinopathy in Chinese patients with type 2 diabetes. Mol Vis. 20:200–214. 2014.PubMed/NCBI

3 

Hivert MF, Vassy JL and Meigs JB: Susceptibility to type 2 diabetes mellitus-from genes to prevention. Nat Rev Endocrinol. 10:198–205. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Zeng C, Shi X, Zhang B, Liu H, Zhang L, Ding W and Zhao Y: The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: Relationship with metabolic factors and complications. J Mol Med (Berl). 90:175–186. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Zhang C, Xiao C, Wang P, Xu W, Zhang A, Li Q and Xu X: The alteration of Th1/Th2/Th17/Treg paradigm in patients with type 2 diabetes mellitus: Relationship with diabetic nephropathy. Hum Immunol. 75:289–296. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Jagannathan-Bogdan M, McDonnell ME, Shin H, Rehman Q, Hasturk H, Apovian CM and Nikolajczyk BS: Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J Immunol. 186:1162–1172. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Dellamea BS, Leitao CB, Friedman R and Canani LH: Nitric oxide system and diabetic nephropathy. Diabetology and Metabolic Syndrome. 6:172014. View Article : Google Scholar : PubMed/NCBI

8 

Okada S, Saito M, Kazuyama E, Hanada T, Kawaba Y, Hayashi A, Satoh K and Kanzaki S: Effects of N-hexacosanol on nitric oxide synthase system in diabetic rat nephropathy. Mol Cell Biochem. 315:169–177. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Tang LL, Liu Q, Bu SZ, Xu LT, Wang QW, Mai YF and Duan SW: The effect of environmental factors and DNA methylation on type 2 diabetes mellitus. Yi Chuan. 35:1143–1152. 2013.(In Chinese). View Article : Google Scholar : PubMed/NCBI

10 

Anderssohn M, McLachlan S, Lüneburg N, Robertson C, Schwedhelm E, Williamson RM, Strachan MW, Ajjan R, Grant PJ, Böger RH and Price JF: Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes. Diabetes Care. 37:846–854. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Nothwehr F and Stump T: Health-promoting behaviors among adults with type 2 diabetes: Findings from the health and retirement study. Prev Med. 30:407–414. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Green AJ, Bazata DD, Fox KM and Grandy S: SHIELD Study Group: Health-related behaviours of people with diabetes and those with cardiometabolic risk factors: Results from SHIELD. Int J Clin Pract. 61:1791–1797. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Alberti KG and Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 15:539–553. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U and Shaw JE: Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 103:137–149. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Mandke P, Wyatt N, Fraser J, Bates B, Berberich SJ and Markey MP: MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame. PLoS One. 7:e420342012. View Article : Google Scholar : PubMed/NCBI

16 

Guay C, Roggli E, Nesca V, Jacovetti C and Regazzi R: Diabetes mellitus, a microRNA-related disease? Transl Res. 157:253–264. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Wu X, Zhong D, Gao Q, Zhai W, Ding Z and Wu J: MicroRNA-34a inhibits human osteosarcoma proliferation by downregulating ether à go-go 1 expression. Int J Med Sci. 10:676–682. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Tan J, Fan L, Mao JJ, Chen B, Zheng L, Zhang T, Li T, Duan J, Duan Y, Jin Z and Kuang W: Restoration of miR-34a in p53 deficient cells unexpectedly promotes the cell survival by increasing NFkB activity. J Cell Biochem. 113:2903–2908. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Okazuka K, Wakabayashi Y, Kashihara M, Inoue J, Sato T, Yokoyama M, Aizawa S, Aizawa Y, Mishima Y and Kominami R: p53 prevents maturation of T cell development to the immature CD4−CD8+ stage in Bcl11b−/− mice. Biochem Biophys Res Commun. 328:545–549. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Zheng SJ, Lamhamedi-Cherradi SE, Wang P, Xu L and Chen YH: Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes. 54:1423–1428. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Zhang S, Zheng M, Kibe R, Huang Y, Marrero L, Warren S, Zieske AW, Iwakuma T, Kolls JK and Cui Y: Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis. FASEB J. 25:2387–2398. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Gururajan M, Haga CL, Das S, Leu CM, Hodson D, Josson S, Turner M and Cooper MD: MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int Immunol. 22:583–592. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Villeneuve LM, Kato M, Reddy MA, Wang M, Lanting L and Natarajan R: Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1. Diabetes. 59:2904–2915. 2010. View Article : Google Scholar : PubMed/NCBI

24 

American Diabetes Association, . Diagnosis and classification of diabetes mellitus. Diabetes Care. 35 Suppl 1:S64–S71. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Tao W, Dong X, Kong G, Fang P, Huang X and Bo P: Elevated circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in type 2 diabetes mellitus with diarrhea-predominant irritable bowel syndrome. Gastroenterol Res Pract. 2016:92562092016. View Article : Google Scholar : PubMed/NCBI

27 

Latouche C, Natoli A, Reddy-Luthmoodoo M, Heywood SE, Armitage JA and Kingwell BA: MicroRNA-194 modulates glucose metabolism and its skeletal muscle expression is reduced in diabetes. PLoS One. 11:e01551082016. View Article : Google Scholar : PubMed/NCBI

28 

Sardu C, Barbieri M, Rizzo MR, Paolisso P, Paolisso G and Marfella R: Cardiac resynchronization therapy outcomes in type 2 diabetic patients: Role of MicroRNA changes. J Diabetes Res. 2016:72925642016. View Article : Google Scholar : PubMed/NCBI

29 

Zhang L, He S, Guo S, Xie W, Xin R, Yu H, Yang F, Qiu J, Zhang D, Zhou S and Zhang K: Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1. J Diabetes Complications. 28:259–264. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, et al: Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 26:745–752. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Wei R, Yang J, Liu GQ, Gao MJ, Hou WF, Zhang L, Gao HW, Liu Y, Chen GA and Hong TP: Dynamic expression of microRNAs during the differentiation of human embryonic stem cells into insulin-producing cells. Gene. 518:246–255. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Chakraborty C, Doss CG, Bandyopadhyay S and Agoramoorthy G: Influence of miRNA in insulin signaling pathway and insulin resistance: Micro-molecules with a major role in type-2 diabetes. Wiley Interdiscip Rev RNA. 5:697–712. 2014.PubMed/NCBI

33 

Chakraborty C, George Priya, Doss C and Bandyopadhyay S: miRNAs in insulin resistance and diabetes-associated pancreatic cancer: The ‘minute and miracle’ molecule moving as a monitor in the ‘genomic galaxy’. Curr Drug Targets. 14:1110–1117. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A and Regazzi R: Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes. 57:2728–2736. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Kong L, Zhu J, Han W, Jiang X, Xu M, Zhao Y, Dong Q, Pang Z, Guan Q, Gao L, et al: Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: A clinical study. Acta Diabetol. 48:61–69. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Nesca V, Guay C, Jacovetti C, Menoud V, Peyot ML, Laybutt DR, Prentki M and Regazzi R: Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes. Diabetologia. 56:2203–2212. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Hotamisligil GS: Inflammation and metabolic disorders. Nature. 444:860–867. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Lasselin J and Capuron L: Chronic low-grade inflammation in metabolic disorders: Relevance for behavioral symptoms. Neuroimmunomodulation. 21:95–101. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Santos VR, Ribeiro FV, Lima JA, Napimoga MH, Bastos MF and Duarte PM: Cytokine levels in sites of chronic periodontitis of poorly controlled and well-controlled type 2 diabetic subjects. J Clin Periodontol. 37:1049–1058. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T and Nomura T: Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev. 212:8–27. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Bettelli E, Oukka M and Kuchroo VK: T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 8:345–350. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Homey B: After TH1/TH2 now comes Treg/TH17: Significance of T helper cells in immune response organization. Hautarzt. 57:730–732. 2006.(In German). View Article : Google Scholar : PubMed/NCBI

43 

Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, Lodish HF and Lim B: MicroRNA-125b is a novel negative regulator of p53. Genes Dev. 23:862–876. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Lin MH, Chou FC, Yeh LT, Fu SH, Chiou HY, Lin KI, Chang DM and Sytwu HK: B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells. Diabetologia. 56:136–146. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Cretney E, Xin A, Shi W, Minnich M, Masson F, Miasari M, Belz GT, Smyth GK, Busslinger M, Nutt SL and Kallies A: The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol. 12:304–311. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Polager S and Ginsberg D: p53 and E2f: Partners in life and death. Nat Rev Cancer. 9:738–748. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Huber M, Brüstle A, Reinhard K, Guralnik A, Walter G, Mahiny A, von Löw E and Lohoff M: IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci USA. 105:pp. 20846–20851. 2008, View Article : Google Scholar : PubMed/NCBI

48 

Allan SE, Crome SQ, Crellin NK, Passerini L, Steiner TS, Bacchetta R, Roncarolo MG and Levings MK: Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol. 19:345–354. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM and Manjili MH: Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J Transl Med. 7:892009. View Article : Google Scholar : PubMed/NCBI

50 

Min HK, Kapoor A, Fuchs M, Mirshahi F, Zhou H, Maher J, Kellum J, Warnick R, Contos MJ and Sanyal AJ: Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 15:665–674. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Li X, Lian F, Liu C, Hu KQ and Wang XD: Isocaloric pair-fed high-carbohydrate diet induced more hepatic steatosis and inflammation than high-fat diet mediated by miR-34a/SIRT1 axis in mice. Sci Rep. 5:167742015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shen Y, Xu H, Pan X, Wu W, Wang H, Yan L, Zhang M, Liu X, Xia S, Shao Q, Shao Q, et al: miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus. Exp Ther Med 14: 5589-5596, 2017.
APA
Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L. ... Shao, Q. (2017). miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 14, 5589-5596. https://doi.org/10.3892/etm.2017.5254
MLA
Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L., Zhang, M., Liu, X., Xia, S., Shao, Q."miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14.6 (2017): 5589-5596.
Chicago
Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L., Zhang, M., Liu, X., Xia, S., Shao, Q."miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5589-5596. https://doi.org/10.3892/etm.2017.5254
Copy and paste a formatted citation
x
Spandidos Publications style
Shen Y, Xu H, Pan X, Wu W, Wang H, Yan L, Zhang M, Liu X, Xia S, Shao Q, Shao Q, et al: miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus. Exp Ther Med 14: 5589-5596, 2017.
APA
Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L. ... Shao, Q. (2017). miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 14, 5589-5596. https://doi.org/10.3892/etm.2017.5254
MLA
Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L., Zhang, M., Liu, X., Xia, S., Shao, Q."miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14.6 (2017): 5589-5596.
Chicago
Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L., Zhang, M., Liu, X., Xia, S., Shao, Q."miR‑34a and miR‑125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5589-5596. https://doi.org/10.3892/etm.2017.5254
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team