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Combined effects of tumor necrosis factor‑α and interleukin‑1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro

  • Authors:
    • Yanjun Zhang
    • Jiahuan Jiang
    • Jing Xie
    • Chunming Xu
    • Chunli Wang
    • Lin Yin
    • Li Yang
    • Kuo‑Li Paul Sung
  • View Affiliations / Copyright

    Affiliations: Department of Life Science, Hunan University of Science and Technology, Xiangtan, Hunan 411201, P.R. China, Laboratory of Biomechanics and Tissue Repair, Bioengineering College, Chongqing University, Chongqing 400044, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5258-5266
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    Published online on: October 3, 2017
       https://doi.org/10.3892/etm.2017.5264
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Abstract

Previous studies have demonstrated that inflammatory cytokines are associated with matrix metalloproteinases (MMPs) and/or lysyl oxidases (LOXs) produced by anterior cruciate ligament (ACL) fibroblasts, which may contribute to the poor healing ability of the ACL. To evaluate whether the synovium also participates in ACL healing, the inflammatory microenvironment of the knee joint cavity was mimicked following ACL injury, and the combined effects of tumor necrosis factor‑α (TNF‑α) and interleukin‑1β (IL‑1β) on the expression of MMPs and LOXs in synovial fibroblasts were studied. Cell viability was evaluated using trypan blue staining in the presence of TNF‑α and IL‑1β, and the expression of LOXs and MMPs was measured by reverse transcription‑quantitative polymerase chain reaction. MMP‑2 activity was also measured by zymography. The results indicated that the combined effects of TNF‑α and IL‑1β inhibited LOX expression, while promoting MMP‑1, ‑2 and ‑3 expression and MMP‑2 activity in synovial fibroblasts. These changes may impede healing by altering the balance between the degradative and biosynthetic arms of the ligament tissue remodeling process. Collectively, the present results suggest that the poor healing ability of cruciate ligaments may be due to the sensitivity of the synovium to inflammatory factors. Therefore, the synovium potentially serves a key regulatory role in the joint cavity microenvironment and in the healing process of the ACL, and thus should be considered as a therapeutic target to aid in the treatment of patients with ACL trauma.
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1 

Woo SL, Abramowitch SD, Kilger R and Liang R: Biomechanics of knee ligaments: Injury, healing, and repair. J Biomech. 39:1–20. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Hill CL, Seo GS, Gale D, Totterman S, Gale ME and Felson DT: Cruciate ligament integrity in osteoarthritis of the knee. Arthritis Rheum. 52:794–799. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Sun K, Zhang J, Wang Y, Xia C, Zhang C, Yu T and Tian S: Arthroscopic reconstruction of the anterior cruciate ligament with hamstring tendon autograft and fresh-frozen allograft: A prospective, randomized controlled study. Am J Sports Med. 39:1430–1438. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Kim HS, Seon JK and Jo AR: Current trends in anterior cruciate ligament reconstruction. Knee Surg Relat Res. 25:165–173. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Bray RC, Leonard CA and Salo PT: Correlation of healing capacity with vascular response in the anterior cruciate and medial collateral ligaments of the rabbit. J Orthop Res. 21:1118–1123. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Nagineni CN, Amiel D, Green MH, Berchuck M and Akeson WH: Characterization of the intrinsic properties of the anterior cruciate and medial collateral ligament cells: An in vitro cell culture study. J Orthop Res. 10:465–475. 1992. View Article : Google Scholar : PubMed/NCBI

7 

Sung KL, Yang L, Whittemore DE, Shi Y, Jin G, Hsieh AH, Akeson WH and Sung LA: The differential adhesion forces of anterior cruciate and medial collateral ligament fibroblasts: Effects of tropomodulin, talin, vinculin, and alpha-actinin. Proc Nati Acad Sci USA. 93:pp. 9182–9187. 1996, View Article : Google Scholar

8 

Wiig ME, Amiel D, Ivarsson M, Naqineni CN, Wallace CD and Arfors KE: Type I procollagen gene expression in normal and early healing of the medial collateral and anterior cruciate ligaments in rabbits: An in situ hybridization study. J Orthop Res. 9:374–382. 1991. View Article : Google Scholar : PubMed/NCBI

9 

Zhou D, Lee HS, Villarreal F, Teng A, Lu E, Reynolds S, Qin C, Smith J and Sung KL: Differential MMP-2 activity of ligament cells under mechanical stretch injury: An in vitro study on human ACL and MCL fibroblasts. J Orthop Res. 23:949–957. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Chithra P, Sajithlal GB and Chandrakasan G: Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem. 181:71–76. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Garqiulo S, Gamba P, Poli G and Leonarduzzi G: Metalloproteinases and metalloproteinase inhibitors in age-related diseases. Curr Pharm Des. 20:2993–3018. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Fan SH, Wang YY, Lu J, Zheng YL, Wu DM, Zhang ZF, Shan Q, Hu B, Li MQ and Cheng W: CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer. J Cell Biochem. 116:502–513. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Vater CA, Harris ED Jr and Siegel RC: Native cross-links in collagen fibrils induce resistance to human synovial collagenase. Biochem J. 181:639–645. 1979. View Article : Google Scholar : PubMed/NCBI

14 

Avery NC and Bailey AJ: Enzymic and non-enzymic cross-linking mechanisms in relation to turnover of collagen: Relevance to aging and exercise. Scand J Med Sci Sports. 15:231–240. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Wang Y, Tang Z, Xue R, Singh GK, Lv Y, Shi K, Cai K, Deng L and Yang L: TGF-β1 promoted MMP-2 mediated wound healing of anterior cruciate ligament fibroblasts through NF-κB. Connect Tissue Res. 52:218–225. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Xie J, Jiang J, Huang W, Zhang Y, Xu C, Wang C, Yin L, Chen PC and Sung KL: TNF-α induced down-regulation of lysyl oxidase family in anterior cruciate ligament and medial collateral ligament fibroblasts. Knee. 21:47–53. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Tang Z, Yang L, Xue R, Zhang J, Wang Y, Chen PC and Sung KL: Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after a mechanical injury: Involvement of the p65 subunit of NF-kappaB. Wound Repair Regen. 17:709–716. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Tang Z, Yang L, Wang Y, Xue R, Zhang J, Huang W, Chen PC and Sung KL: Contributions of different intraarticular tissues to the acute phase elevation of synovial fluid MMP-2 following rat ACL rupture. J Orthop Res. 27:243–248. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Wang Y, Yang L, Zhang J, Xue R, Tang Z, Huang W, Jiang D, Tang X, Chen P and Sung KL: Differential MMP-2 activity induced by mechanical compression and inflammatory factors in human synoviocytes. Mol Cell Biomech. 7:105–114. 2010.PubMed/NCBI

20 

Zhang Y, Huang W, Jiang J, Xie J, Xu C, Wang C, Yin L, Yang L, Zhou K, Chen P and Sung KP: Influence of TNF-α and biomechanical stress on matrix metalloproteinases and lysyl oxidases expressions in human knee synovial fibroblasts. Knee Surg Sports Traumatol Arthrosc. 22:1997–2006. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Irie K, Uchiyama E and Iwaso H: Intraarticular inflammatory cytokines in acute anterior cruciate ligament injured knee. Knee. 10:93–96. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Behm B, Babilas P, Landthaler M and Schreml S: Cytokines, chemokines and growth factors in wound healing. J Acad Dermatol Venereol. 26:812–820. 2012. View Article : Google Scholar

23 

Xie J, Wang C, Yin L, Xu C, Zhang Y and Sung KL: Interleukin-1 beta influences on lysyl oxidases and matrix metalloproteinases profile of injured anterior cruciate ligament and medial collateral ligament fibroblasts. Int Orthop. 37:495–505. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Sinno H and Prakash S: Complements and the wound healing cascade: An updated review. Plast Surg Int. 2013:1467642013.PubMed/NCBI

26 

Barrientos S, Brem H, Stojadinovic O and Tomic-Canic M: Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen. 22:569–578. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Migita K, Eguchi K, Kawabe Y, Ichinose Y, Tsukada T, Aoyagi T, Nakamura H and Nagataki S: TNF-alpha-mediated expression of membrane-type matrix metalloproteinase in rheumatoid synovial fibroblasts. Immunology. 89:553–557. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Soller JT, Murua-Escobar H, Willenbrock S, Janssen M, Eberle N, Bullerdiek J and Nolte I: Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians. J Hered. 98:485–490. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Shona MI, Shaun G and David MT: Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1beta and TNF-alpha. Mediators Inflamm. 9:155–160. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Guirao X and Lowry SF: Biologic control of injury and inflammation: Much more than too little or too late. World J Surg. 20:437–446. 1996. View Article : Google Scholar : PubMed/NCBI

31 

Menke NB, Ward KR, Witten TM, Bonchev DG and Diegelmann RF: Impaired wound healing. Clin Dermatol. 25:19–25. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Di Giovine FS, Nuki G and Duff GW: Tumour necrosis factor in synovial exudates. Ann Rheum Dis. 47:768–772. 1988. View Article : Google Scholar : PubMed/NCBI

33 

Cameron ML, Fu FH, Paessler HH, Schneider M and Evans CH: Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee. Knee Surg Sports Traumatol Arthrosc. 2:38–44. 1994. View Article : Google Scholar : PubMed/NCBI

34 

Choi HM, Oh DH, Bang JS, Yang HI, Yoo MC and Kim KS: Differential effect of IL-1β and TNFα on the production of IL-6, IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages. Rheumatol Int. 30:1025–1033. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Witkowski J, Yang L, Wood DJ and Sung KL: Migration and healing of ligament cells under inflammatory conditions. J Orthop Res. 15:269–277. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Greenwel P, Tanaka S, Penkov D, Zhang W, Olive M, Moll J, Vinson C, Di Liberto M and Ramirez F: Tumor necrosis factor alpha inhibits type I collagen synthesis through repressive CCAAT/enhancer-binding proteins. Mol Cell Biol. 20:912–918. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Murakami H, Shinomiya N, Kikuchi T, Yoshihara Y and Nemoto K: Upregulated expression of inducible nitric oxide synthase plays a key role in early apoptosis after anterior cruciate ligament injury. J Orthop Res. 24:1521–1534. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Wang Y, Tang Z, Xue R, Singh GK, Shi K, Lv Y and Yang L: Combined effects of TNF-α, IL-1β, and HIF-1α on MMP-2 production in ACL fibroblasts under mechanical stretch: An in vitro study. J Orthop Res. 29:1008–1014. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Fu C, Xie J, Chen R, Wang C, Xu C, Chen C, Wang Z, Lin L, Huang W, Liang X and Sung KL: Effect of titanium particles and TNF-alpha on the gene expression and activity of MMP-1, 2, 3 in human knee joint synovial cells. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 30:1022–1026. 2013.(In Chinese). PubMed/NCBI

40 

Schulze-Tanzil G, Al-Sadi O, Wiegand E, Ertel W, Busch C, Kohl B and Pufe T: The role of pro-inflammatory and immunoregulatory cytokines in tendon healing and rupture: New insights. Scand J Med Sci Sports. 21:337–351. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Nakaya H, Oates TW, Hoang AM, Kamoi K and Cochran DL: Effects of interleukin-1beta on matrix metalloproteinase-3 levels in human periodontal ligament cells. J Periodontol. 68:517–523. 1997. View Article : Google Scholar : PubMed/NCBI

42 

Ahn SJ, Rhim EM, Kim JY, Kim KH, Lee HW, Kim EC and Park SH: Tumor necrosis factor-α induces matrix metalloproteinases-3, −10 and −13 in human periodontal ligament cells. J Periodontol. 85:490–497. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Raymond L, Eck S, Hays E, Tomek I, Kantor S and Vincenti M: RelA is required for IL-1beta stimulation of matrix metalloproteinase-1 expression in chondrocytes. Osteoarthritis Cartilage. 15:431–441. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Dunn SL, Wilkinson JM, Crawford A, Le Maitre CL and Bunning RA: Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes. Osteoarthritis Cartilage. 22:133–144. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Zhong Y, Yu W, Feng J, Fan J and Li J: Curcumin suppresses tumor necrosis factor-α-induced matrix metalloproteinase-2 expression and activity in rat vascular smooth muscle cells via the NF-κB pathway. Exp Ther Med. 7:1653–1658. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Gotoh K, Nemoto E, Kanaya S and Shimauchi H: Extracellular β-NAD(+) inhibits interleukin-1-induced matrix metalloproteinase-1 and −3 expression on human gingival fibroblasts. Connect Tissue Res. 54:204–209. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Kerrigan JJ, Mansell JP and Sandy JR: Matrix turnover. J Orthod. 27:227–233. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Rodríguez D, Morrison C and Overall CM: Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics. Biochim Biophys Acta. 1803:39–54. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Trackman PC, Graham RJ, Bittner HK, Carnes DL, Gilles JA and Graves DT: Inflammation-associated lysyl oxidase protein expression in vivo, and modulation by FGF-2 plus IGF-1. Histochem Cell Biol. 110:9–14. 1998. View Article : Google Scholar : PubMed/NCBI

50 

Desmoulière A, Darby I, Costa AM, Raccurt M, Tuchweber B, Sommer P and Gabbiani G: Extracellular matrix deposition, lysyl oxidase expression, and myofibroblastic differentiation during the initial stages of cholestatic fibrosis in the rat. Lab Invest. 76:765–778. 1997.PubMed/NCBI

51 

Roy R, Polgar P, Wang Y, Goldstein RH, Taylor L and Kagan HM: Regulation of lysyl oxidase and cyclooxygenase expression in human lung fibroblast: Interaction among TGF-beta, IL-1 beta, and prostaglandin E. J Cell Biochem. 62:411–417. 1996. View Article : Google Scholar : PubMed/NCBI

52 

Cenizo V, André V, Reymermier C, Sommer P, Damour O and Perrier E: LOXL as a target to increase the elastin content in adult skin: A dill extract induces the LOXL gene expression. Exp Dermatol. 15:574–581. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Jiang J, Xie J, Xu C, Wang C, Yin L, Yang L and Sung KLP: Combined effects of tumor necrosis factor‑α and interleukin‑1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro. Exp Ther Med 14: 5258-5266, 2017.
APA
Zhang, Y., Jiang, J., Xie, J., Xu, C., Wang, C., Yin, L. ... Sung, K.P. (2017). Combined effects of tumor necrosis factor‑α and interleukin‑1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro. Experimental and Therapeutic Medicine, 14, 5258-5266. https://doi.org/10.3892/etm.2017.5264
MLA
Zhang, Y., Jiang, J., Xie, J., Xu, C., Wang, C., Yin, L., Yang, L., Sung, K. P."Combined effects of tumor necrosis factor‑α and interleukin‑1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro". Experimental and Therapeutic Medicine 14.6 (2017): 5258-5266.
Chicago
Zhang, Y., Jiang, J., Xie, J., Xu, C., Wang, C., Yin, L., Yang, L., Sung, K. P."Combined effects of tumor necrosis factor‑α and interleukin‑1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5258-5266. https://doi.org/10.3892/etm.2017.5264
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Jiang J, Xie J, Xu C, Wang C, Yin L, Yang L and Sung KLP: Combined effects of tumor necrosis factor‑α and interleukin‑1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro. Exp Ther Med 14: 5258-5266, 2017.
APA
Zhang, Y., Jiang, J., Xie, J., Xu, C., Wang, C., Yin, L. ... Sung, K.P. (2017). Combined effects of tumor necrosis factor‑α and interleukin‑1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro. Experimental and Therapeutic Medicine, 14, 5258-5266. https://doi.org/10.3892/etm.2017.5264
MLA
Zhang, Y., Jiang, J., Xie, J., Xu, C., Wang, C., Yin, L., Yang, L., Sung, K. P."Combined effects of tumor necrosis factor‑α and interleukin‑1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro". Experimental and Therapeutic Medicine 14.6 (2017): 5258-5266.
Chicago
Zhang, Y., Jiang, J., Xie, J., Xu, C., Wang, C., Yin, L., Yang, L., Sung, K. P."Combined effects of tumor necrosis factor‑α and interleukin‑1β on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5258-5266. https://doi.org/10.3892/etm.2017.5264
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