Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E‑deficient mice

  • Authors:
    • Yong‑Hoon Kim
    • Jung‑Ran Noh
    • Jung Hwan Hwang
    • Kyoung‑Shim Kim
    • Dong‑Hee Choi
    • Jin‑Pyo An
    • Won‑Keun Oh
    • Chul‑Ho Lee
  • View Affiliations / Copyright

    Affiliations: Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea, Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5863-5870
    |
    Published online on: October 10, 2017
       https://doi.org/10.3892/etm.2017.5271
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sicyos angulatus (SA), a summer annual vine originating from Northeastern USA, is a widely distributed noxious invasive plant. However, the clinical application of SA has not been investigated previously. The purpose of present study was to determine the effects of SA on atherosclerosis and its underlying mechanism. Atherosclerosis was induced by feeding apolipoprotein E‑deficient (apoE‑/‑) mice with an atherogenic diet for 8 weeks. SA was administered daily by oral gavage during induction of atherosclerosis. ApoE‑/‑ mice treated with SA demonstrated a significant reduction in atherosclerotic plaque area in the whole aorta and aortic sinus compared with vehicle‑treated mice. The plasma lipid profiles, including triglyceride, total cholesterol, high‑density lipoprotein and low‑density lipoprotein, were not affected by SA administration. Of note, gene expression levels of proatherogenic cytokines including tumor necrosis factor α (Tnfα) and interleukin‑6 (Il‑6) were significantly decreased in the aorta of SA administered apoE‑/‑ mice. In lipopolysaccharide‑stimulated RAW 264.7 macrophage cells, SA also inhibited the induction Tnfa, Il‑6 and Il‑1β in a dose‑dependent manner. Furthermore, gene expression levels of endothelial cell adhesion molecules, including vascular cell adhesion protein 1 and intercellular adhesion molecule 1 were reduced in the aorta of apoE‑/- mice treated with SA, which was followed by diminished aortic infiltration of monocytes/macrophages. In conclusion, to the best of our knowledge, this is the first study to demonstrate that SA is able to suppress the development of atherosclerosis by inhibiting the aortic expression of proinflammatory factors in atherogenic diet‑fed apoE‑/‑ mice. The present study may provide novel insights into the application of the environmentally problematic weed SA as a therapeutically effective natural product for preventing atherosclerosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Lusis AJ: Atherosclerosis. Nature. 407:233–241. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C, et al: Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation. 135:e146–e603. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Vargas JD, Manichaikul A, Wang XQ, Rich SS, Rotter JI, Post WS, Polak JF, Budoff MJ and Bluemke DA: Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 245:230–236. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Hicken MT, Adar SD, Hajat A, Kershaw KN, Do DP, Barr RG, Kaufman JD and Diez Roux AV: Air pollution, cardiovascular outcomes and social disadvantage: The Multi-ethnic Study of Atherosclerosis. Epidemiology. 27:42–50. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Spring B, Moller AC, Colangelo LA, Siddique J, Roehrig M, Daviglus ML, Polak JF, Reis JP, Sidney S and Liu K: Healthy lifestyle change and subclinical atherosclerosis in young adults: Coronary Artery Risk Development in Young Adults (CARDIA) study. Circulation. 130:10–17. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Tian J, Gu X, Sun Y, Ban X, Xiao Y, Hu S and Yu B: Effect of statin therapy on the progression of coronary atherosclerosis. BMC Cardiovasc Disord. 12:702012. View Article : Google Scholar : PubMed/NCBI

7 

Hoffmann H, Frieler K, Schlattmann P, Hamm B and Dewey M: Influence of statin treatment on coronary atherosclerosis visualised using multidetector computed tomography. Eur Radiol. 20:2824–2833. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Tabas I, García-Cardeña G and Owens GK: Recent insights into the cellular biology of atherosclerosis. J Cell Biol. 209:13–22. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Witztum JL and Steinberg D: Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 88:1785–1792. 1991. View Article : Google Scholar : PubMed/NCBI

10 

Libby P: Inflammation in atherosclerosis. Nature. 420:868–874. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Rocha VZ and Libby P: Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol. 6:399–409. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Hansson GK and Libby P: The immune response in atherosclerosis: A double-edged sword. Nat Rev Immunol. 6:508–519. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Kobayashi H, Kurokawa S and Ikeda K: Dairyland populations of bur cucumber (Sicyos angulatus) as a possible seed source for riverbank populations along the Abukuma River, Japan. Weed Biol Manag. 12:147–155. 2012. View Article : Google Scholar

14 

Lee SM, Radhakrishnan R, Kang SM, Kim JH, Lee IY, Moon BK, Yoon BW and Lee IJ: Phytotoxic mechanisms of bur cucumber seed extracts on lettuce with special reference to analysis of chloroplast proteins, phytohormones and nutritional elements. Ecotoxicol Environ Saf. 122:230–237. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Hulina N: New dangerous weed in Croatia: Sicyos angulatus L. (Cucurbitaceae). Poljopr Znan Smotra. 61:259–264. 1996.

16 

Watanabe O, Kurokawa S, Sasaki H, Nishida T, Onoue T and Yoshimura Y: Geographic scale distribution and occurrence pattern of invasive weeds. Grassl Sci. 48:440–450. 2002.

17 

Badimon L and Vilahur G: LDL-cholesterol versus HDL-cholesterol in the atherosclerotic plaque: Inflammatory resolution versus thrombotic chaos. Ann N Y Acad Sci. 1254:18–32. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Ait-Oufella H, Taleb S, Mallat Z and Tedgui A: Recent advances on the role of cytokines in atherosclerosis. Arterioscler Thromb Vasc Biol. 31:969–979. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Ramji DP and Davies TS: Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets. Cytokine Growth Factor Rev. 26:673–685. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Blankenberg S, Barbaux S and Tiret L: Adhesion molecules and atherosclerosis. Atherosclerosis. 170:191–203. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Merritt WT: Nitric oxide: An important bioregulator. Transplant Proc. 25:2014–2016. 1993.PubMed/NCBI

22 

Gimbrone MA Jr and García-Cardeña G: Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 118:620–636. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Vidal F, Colomé C, Martínez-González J and Badimon L: Atherogenic concentrations of native low-density lipoproteins down-regulate nitric-oxide-synthase mRNA and protein levels in endothelial cells. Eur J Biochem. 252:378–384. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Law MR, Wald NJ and Rudnicka AR: Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review and meta-analysis. BMJ. 326:14232003. View Article : Google Scholar : PubMed/NCBI

25 

Trigatti BL, Krieger M and Rigotti A: Influence of the HDL receptor SR-BI on lipoprotein metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol. 23:1732–1738. 2003. View Article : Google Scholar : PubMed/NCBI

26 

McLaren JE, Michael DR, Ashlin TG and Ramji DP: Cytokines, macrophage lipid metabolism and foam cells: Implications for cardiovascular disease therapy. Prog Lipid Res. 50:331–347. 2011. View Article : Google Scholar : PubMed/NCBI

27 

McKellar GE, McCarey DW, Sattar N and McInnes IB: Role for TNF in atherosclerosis? Lessons from autoimmune disease. Nat Rev Cardiol. 6:410–417. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Pober JS and Sessa WC: Evolving functions of endothelial cells in inflammation. Nat Rev Immunol. 7:803–815. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Ohta H, Wada H, Niwa T, Kirii H, Iwamoto N, Fujii H, Saito K, Sekikawa K and Seishima M: Disruption of tumor necrosis factor-alpha gene diminishes the development of atherosclerosis in ApoE-deficient mice. Atherosclerosis. 180:11–17. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Huber SA, Sakkinen P, Conze D, Hardin N and Tracy R: Interleukin-6 exacerbates early atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 19:2364–2367. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Zhang K, Huang XZ, Li XN, Feng M, Li L, Cai XJ, Zhang C, Liu XL, Zhang MX, Zhang Y, et al: Interleukin 6 destabilizes atherosclerotic plaques by downregulating prolyl-4-hydroxylase alpha1 via a mitogen-activated protein kinase and c-Jun pathway. Arch Biochem Biophys. 528:127–133. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, Bavendiek U, von Felden J, Divchev D, Kempf T, et al: Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 32:281–290. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Schieffer B, Selle T, Hilfiker A, Hilfiker-Kleiner D, Grote K, Tietge UJ, Trautwein C, Luchtefeld M, Schmittkamp C, Heeneman S, et al: Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis. Circulation. 110:3493–3500. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Song L and Schindler C: IL-6 and the acute phase response in murine atherosclerosis. Atherosclerosis. 177:43–51. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Kirii H, Niwa T, Yamada Y, Wada H, Saito K, Iwakura Y, Asano M, Moriwaki H and Seishima M: Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 23:656–660. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Clarke MC, Talib S, Figg NL and Bennett MR: Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: Effects of hyperlipidemia-mediated inhibition of phagocytosis. Circ Res. 106:363–372. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Shemesh S, Kamari Y, Shaish A, Olteanu S, Kandel-Kfir M, Almog T, Grosskopf I, Apte RN and Harats D: Interleukin-1 receptor type-1 in non-hematopoietic cells is the target for the pro-atherogenic effects of interleukin-1 in apoE-deficient mice. Atherosclerosis. 222:329–336. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Weber C, Zernecke A and Libby P: The multifaceted contributions of leukocyte subsets to atherosclerosis: Lessons from mouse models. Nat Rev Immunol. 8:802–815. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Moore KJ, Sheedy FJ and Fisher EA: Macrophages in atherosclerosis: A dynamic balance. Nat Rev Immunol. 13:709–721. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Akihisa T, Tamura T and Matsumoto T: 24-Methylene-25-methyllathosterol: A sterol from Sicyos angulatus. Phytochemistry. 26:575–577. 1987. View Article : Google Scholar

41 

Na CS, Lee YH, Murai Y, Iwashina T, Kim TW and Hong SH: Flavonol 3,7-diglycosides from the aerial parts of Sicyos angulatus (Cucurbitaceae) in Korea and Japan. Biochem Syst Ecol. 48:235–237. 2013. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim YH, Noh JR, Hwang JH, Kim KS, Choi DH, An JP, Oh WK and Lee CH: Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E‑deficient mice. Exp Ther Med 14: 5863-5870, 2017.
APA
Kim, Y., Noh, J., Hwang, J.H., Kim, K., Choi, D., An, J. ... Lee, C. (2017). Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E‑deficient mice. Experimental and Therapeutic Medicine, 14, 5863-5870. https://doi.org/10.3892/etm.2017.5271
MLA
Kim, Y., Noh, J., Hwang, J. H., Kim, K., Choi, D., An, J., Oh, W., Lee, C."Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 14.6 (2017): 5863-5870.
Chicago
Kim, Y., Noh, J., Hwang, J. H., Kim, K., Choi, D., An, J., Oh, W., Lee, C."Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5863-5870. https://doi.org/10.3892/etm.2017.5271
Copy and paste a formatted citation
x
Spandidos Publications style
Kim YH, Noh JR, Hwang JH, Kim KS, Choi DH, An JP, Oh WK and Lee CH: Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E‑deficient mice. Exp Ther Med 14: 5863-5870, 2017.
APA
Kim, Y., Noh, J., Hwang, J.H., Kim, K., Choi, D., An, J. ... Lee, C. (2017). Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E‑deficient mice. Experimental and Therapeutic Medicine, 14, 5863-5870. https://doi.org/10.3892/etm.2017.5271
MLA
Kim, Y., Noh, J., Hwang, J. H., Kim, K., Choi, D., An, J., Oh, W., Lee, C."Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 14.6 (2017): 5863-5870.
Chicago
Kim, Y., Noh, J., Hwang, J. H., Kim, K., Choi, D., An, J., Oh, W., Lee, C."Sicyos angulatus ameliorates atherosclerosis through downregulation of aortic inflammatory responses in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5863-5870. https://doi.org/10.3892/etm.2017.5271
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team