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Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells

  • Authors:
    • Ke Zhang
    • Zhanjun Liu
    • Ji Li
    • Juan Li
    • Jianghong Yan
    • Yunchuan Su
    • Shuying Li
    • Jintao Li
  • View Affiliations / Copyright

    Affiliations: Hebei Key Laboratory for Chronic Diseases/Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5817-5824
    |
    Published online on: October 11, 2017
       https://doi.org/10.3892/etm.2017.5279
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Abstract

To explore the significance of human papilloma virus type 52 (HPV52) infection and its integration in cells within cervical lesions, the expression levels of HPV52 were detected using polymerase chain reaction (PCR). The copy numbers of HPV52 E2, HPV52 E6 and the reference gene β‑actin were determined by quantitative PCR to analyze the association between HPV52 integration and cervical lesions. HPV52 integration was analyzed by the amplification of papillomavirus oncogene transcripts. A total of 13 samples from 468 cases were positive for HPV52. Among the samples, 1 case with an E2/E6 ratio >1 was purely episomal, 3 cases with an E2/E6 ratio of 0 were purely integrated, and 9 cases with an E2/E6 ratio of between 0 and 1 were a mixture of integrated and episomal. With the progression of cervical disease, the prevalence of the episomal type decreased gradually, and the prevalence of the integrated (episomal and integrated) forms increased. The pure integration of HPV52 occurred in chromosomes 2, 5 and 8. These results indicate that HPV52 integration into the host genome may be a key factor in cervical lesions. Thus, patients at high risk for cervical lesions may potentially be identified by screening for HPV52 infection and integration.
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View References

1 

Oh JK and Weiderpass E: Infection and cancer: Global distribution and burden of diseases. Ann Glob Health. 80:384–392. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Arbyn M, Castellsagué X, de Sanjosé S, Bruni L, Saraiya M, Bray F and Ferlay J: Worldwide burden of cervical cancer in 2008. Ann Oncol. 22:2675–2686. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Vaccarella S, Laversanne M, Ferlay J and Bray F: Cervical cancer in Africa, Latin America and the Caribbean and Asia: Regional inequalities and changing trends. Int J Cancer. Jul 22–2017.(Epub ahead of print). View Article : Google Scholar

4 

Nayir T, Okyay RA, Nazlican E, Yesilyurt H, Akbaba M, Ilhan B and Kemik A: Cervical cancer screening in an early diagnosis and screening center in mersin, Turkey. Asian Pac J Cancer Prev. 16:6909–6912. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

6 

zur Hansen H: Papillomaviruses and cancer: From basic studies to clinical application. Nat Rev Cancer. 2:342–350. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Bzhalava D, Eklund C and Dillner J: International standardization and classification of human papillomavirus types. Virology. 476:341–344. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Arbyn M, Tommasino M, Depuydt C and Dillner J: Are 20 human papillomavirus types causing cervical cancer? J Pathol. 234:431–435. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Doorbar J, Egawa N, Griffin H, Kranjec C and Murakami I: Human papillomavirus molecular biology and disease association. Rev Med Virol. 25 Suppl 1:S2–S23. 2015. View Article : Google Scholar

10 

de Sanjose S, Quint WG, Alemany L, Geraets DT, Klaustermeier JE, Lloveras B, Tous S, Felix A, Bravo LE, Shin HR, et al: Human papillomavirus genotype attribution in invasive cervical cancer: A retrospective cross-sectional worldwide study. Lancet Oncol. 11:1048–1056. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Smith JS, Lindsay L, Hoots B, Keys J, Franceschi S, Winer R and Clifford GM: Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: A meta-analysis update. Int J Cancer. 121:621–632. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Onuki M, Matsumoto K, Satoh T, Oki A, Okada S, Minaguchi T, Ochi H, Nakao S, Someya K, Yamada N, et al: Human papillomavirus infections among Japanese women: Age-related prevalence and type-specific risk for cervical cancer. Cancer Sci. 100:1312–1316. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Li N, Franceschi S, Howell-Jones R, Snijders PJ and Clifford GM: Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication. Int J Cancer. 128:927–935. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Azuma Y, Kusumoto-Matsuo R, Takeuchi F, Uenoyama A, Kondo K, Tsunoda H, Nagasaka K, Kawana K, Morisada T, Iwata T, et al: Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in Japanese women. Jpn J Clin Oncol. 44:910–917. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Chan PK, Ho WC, Chan MC, Wong MC, Yeung AC, Chor JS and Hui M: Meta-analysis on prevalence and attribution of human papillomavirus types 52 and 58 in cervical neoplasia worldwide. PLoS One. 9:e1075732014. View Article : Google Scholar : PubMed/NCBI

16 

Graham SV: Human Papillomavirus E2 Protein: Linking replication, transcription and RNA processing. J Virol. 90:8384–8388. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Chaiwongkot A, Vinokurova S, Pientong C, Ekalaksananan T, Kongyingyoes B, Kleebkaow P, Chumworathayi B, Patarapadungkit N, Reuschenbach M and von Knebel Doeberitz M: Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions. Int J Cancer. 132:2087–2094. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Alp Avcı G: Genomic organization and proteins of human papillomavirus. Mikrobiyol Bul. 46:507–515. 2012.(In Turkish). PubMed/NCBI

19 

Akagi K, Li J, Broutian TR, Padilla-Nash H, Xiao W, Jiang B, Rocco JW, Teknos TN, Kumar B, Wangsa D, et al: Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res. 24:185–199. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Raybould R, Fiander A, Wilkinson GW and Hibbitts S: HPV integration detection in CaSki and SiHa using detection of integrated papillomavirus sequences and restriction-site PCR. J Virol Methods. 206:51–54. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Klaes R, Woerner SM, Ridder R, Wentzensen N, Duerst M, Schneider A, Lotz B, Melsheimer P and von Knebel Doeberitz M: Dectection of High-Risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res. 59:6132–6136. 1999.PubMed/NCBI

22 

Karlsen F, Kalantari M, Jenkins A, Pettersen E, Kristensen G, Holm R, Johansson B and Hagmar B: Use of Multiple PCR Sets for Optimal Detection of Human papillomavirus. J Clin Microbiol. 34:2095–2100. 1996.PubMed/NCBI

23 

Hillemanns P and Wang XL: Integration of HPV-16 and HPV-18 DNA in vulvar intraepithelial neoplasia. Gynecol Oncol. 100:276–282. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Klimov E, Vinokourova S, Moisjak E, Rakhmanaliev E, Kobseva V, Laimins L, Kisseljov F and Sulimova G: Human papilloma viruses and cervical tumours: Mapping of integration sites and analysis of adjacent cellular sequences. BMC Cancer. 2:242002. View Article : Google Scholar : PubMed/NCBI

25 

Ok Atılgan A, Tepeoğlu M, Haberal AN, Durukan E, Kuşcu E and Haberal M: Papanicolaou smear findings in solid-organ transplant recipients compared with normal subjects according to the Bethesda 2001 system. Exp Clin Transplant. 13 Suppl 1:S219–S222. 2015.

26 

Al-Kadri HM, Kamal M, Bamuhair SS, Omair AA and Bamefleh HS: Prevalence and characteristics of abnormal Papanicolaou smear in Central Saudi Arabia. Saudi Med J. 36:117–122. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Psifidi A, Dovas CI and Banos G: A comparison of six methods for genomic DNA extraction suitable for PCR-based genotypingapplications using ovine milk samples. Mol Cell Probes. 24:93–98. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Psifidi A, Dovas CI, Bramis G, Lazou T, Russel CL, Arsenos G and Banos G: Comparison of eleven methods for genomic DNA extraction suitable for large-scale whole-genome genotyping and long-Term DNA banking using blood samples. PLoS One. 10:e01159602015. View Article : Google Scholar : PubMed/NCBI

29 

Kim ST, Chun JW, Park G and Koh JW: Comparative quantification of plasma TDRD7 mRNA in cataract patients by real-time polymerase chain reaction. Korean J Ophthalmol. 28:343–350. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Yuan B, Li XY, Zhu T, Yuan L, Hu JP, Chen J, Gao W and Ren WZ: Antibody study in canine distemper virus nucleocapsid protein gene-immunized mice. Genet Mol Res. 14:3098–3105. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Das P, Thomas A, Kannan S, Deodhar K, Shrivastava SK, Mahantshetty U and Mulherkar R: Human papillomavirus (HPV) genome status & cervical cancer outcome-A retrospective study. Indian J Med Res. 142:525–532. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Onyekwuluje JM, Steinau M, Swan DC and Unger ER: A real-time PCR assay for HPV52 detection and viral load quantification. Clin Lab. 58:61–66. 2012.PubMed/NCBI

34 

Ardhaoui M, Ennaifer E, Letaief H, Salsabil R, Lassili T, Chahed K, Bougatef S, Bahrini A, El Fehri E, Ouerhani K, et al: Prevalence, genotype distribution and risk factors for cervical human papillomavirus infection in the grand tunis region, Tunisia. PLoS One. 11:e01574322016. View Article : Google Scholar : PubMed/NCBI

35 

Salehi-Vaziri M, Sadeghi F, Bokharaei-Salim F, Younesi S, Alinaghi S, Monavari SH and Keyvani H: The prevalence and genotype distribution of human papillomavirus in the genital tract of males in Iran. Jundishapur J Microbiol. 8:e219122015. View Article : Google Scholar : PubMed/NCBI

36 

Ewaisha R, Meshay I, Resnik J, Katchman BA and Anderson KS: Programmable protein arrays for immunoprofiling HPV-associated cancers. Proteomics. 16:1215–1224. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Castle PE, Schiffman M, Scott DR, Sherman ME, Glass AG, Rush BB, Schussler JE, Wacholder S and Lorincz AT: Semiquantitative human papillomavirus type 16 viral load and the prospective risk of cervicalprecancer and cancer. Cancer Epidemiol Biomarkers Prev. 14:1311–1314. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Shukla S, Mahata S, Shishodia G, Pande S, Verma G, Hedau S, Bhambhani S, Kumari A, Batra S, Basir SF, et al: Physical state & copy number of high risk human papillomavirus type 16 DNA in progression of cervical cancer. Indian J Med Res. 139:531–543. 2014.PubMed/NCBI

39 

Wentzensen N, Gravitt PE, Long R, Schiffman M, Dunn ST, Carreon JD, Allen RA, Gunja M, Zuna RE, Sherman ME, et al: Human papillomavirus load measured by Linear Array correlates with quantitative PCR in cervical cytology specimens. J Clin Microbiol. 50:1564–1570. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Theelen W, Reijans M, Simons G, Ramaekers FC, Speel EJ and Hopman AH: A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers. Int J Cancer. 126:959–975. 2010.PubMed/NCBI

41 

Jacobs MV, Walboomers JM, van Beek J, Voorhorst FJ, Verheijen RH, Meijer CJ, van den Brule AJ, Helmerhorst TJ and Snijders PJ: A quantitative polymerase chain reaction-enzyme immunoassay for accurate measurements of human papillomavirus type 16 DNA levels in cervical scrapings. Br J Cancer. 81:114–121. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Constandinou-Williams C, Collins SI, Roberts S, Young LS, Woodman CB and Murray PG: Is human papillomavirus viral load a clinically useful predictive marker? A longitudinal study. Cancer Epidemiol Biomarkers Prev. 19:832–837. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Zhang R, He YF, Chen M, Chen CM, Zhu QJ, Lu H, Wei ZH, Li F, Zhang XX, Xu CJ and Yu L: Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous/cancerous lesions: a comparison of E2/E6E7 ratio-based vs. Multiple E1-L1/E6E7 ratio-based detection techniques. J Transl Med. 12:2822014. View Article : Google Scholar : PubMed/NCBI

44 

Kadaja M, Sumerina A, Verst T, Ojarand M, Ustav E and Ustav M: Genomic instability of the host cell induced by the human papillomavirus replication machinery. EMBO J. 26:2180–2191. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Johansson C, Somberg M, Li X, Winquist Backström E, Fay J, Ryan F, Pim D, Banks L and Schwartz S: HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation. EMBO J. 31:3212–3227. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Al-Shabanah OA, Hafez MM, Hassan ZK, Sayed-Ahmed MM, Abozeed WN, Al-Rejaie SS and Alsheikh AA: Human papillomavirus genotyping and integration in ovarian cancer Saudi patients. Virol J. 10:3432013. View Article : Google Scholar : PubMed/NCBI

47 

Das P, Thomas A, Mahantshetty U, Shrivastava SK, Deodhar K and Mulherkar R: HPV genotyping and site of viral integration in cervical cancers in Indian women. PLoS One. 7:e410122012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang K, Liu Z, Li J, Li J, Yan J, Su Y, Li S and Li J: Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells. Exp Ther Med 14: 5817-5824, 2017.
APA
Zhang, K., Liu, Z., Li, J., Li, J., Yan, J., Su, Y. ... Li, J. (2017). Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells. Experimental and Therapeutic Medicine, 14, 5817-5824. https://doi.org/10.3892/etm.2017.5279
MLA
Zhang, K., Liu, Z., Li, J., Li, J., Yan, J., Su, Y., Li, S., Li, J."Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells". Experimental and Therapeutic Medicine 14.6 (2017): 5817-5824.
Chicago
Zhang, K., Liu, Z., Li, J., Li, J., Yan, J., Su, Y., Li, S., Li, J."Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5817-5824. https://doi.org/10.3892/etm.2017.5279
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang K, Liu Z, Li J, Li J, Yan J, Su Y, Li S and Li J: Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells. Exp Ther Med 14: 5817-5824, 2017.
APA
Zhang, K., Liu, Z., Li, J., Li, J., Yan, J., Su, Y. ... Li, J. (2017). Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells. Experimental and Therapeutic Medicine, 14, 5817-5824. https://doi.org/10.3892/etm.2017.5279
MLA
Zhang, K., Liu, Z., Li, J., Li, J., Yan, J., Su, Y., Li, S., Li, J."Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells". Experimental and Therapeutic Medicine 14.6 (2017): 5817-5824.
Chicago
Zhang, K., Liu, Z., Li, J., Li, J., Yan, J., Su, Y., Li, S., Li, J."Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5817-5824. https://doi.org/10.3892/etm.2017.5279
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