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Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis

  • Authors:
    • Yuchao Jing
    • Haofei Liu
    • Wenwen Xu
    • Qian Yang
  • View Affiliations / Copyright

    Affiliations: College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China
    Copyright: © Jing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6069-6073
    |
    Published online on: October 11, 2017
       https://doi.org/10.3892/etm.2017.5282
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Abstract

Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments have poor tolerability and insufficient therapeutic efficacy, thus, alternative therapeutic approaches are required. Recently, a number of dietary supplements have emerged as promising interventions. In the present study oral administration of a carotenoid (4,4'‑diaponeurosporene)‑producing Bacillus subtilis markedly ameliorated dextran sulfate sodium salt‑induced mouse colitis, as demonstrated by a reduction in weight loss and the severity of bleeding, which indicated that 4,4'‑diaponeurosporene may have beneficial effects on treatments for colitis. This preliminary study indicated that 4,4'‑diaponeurosporene may function synergistically with probiotics to provide a novel and effective strategy to prevent colitis.
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Copy and paste a formatted citation
Spandidos Publications style
Jing Y, Liu H, Xu W and Yang Q: Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis. Exp Ther Med 14: 6069-6073, 2017.
APA
Jing, Y., Liu, H., Xu, W., & Yang, Q. (2017). Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis. Experimental and Therapeutic Medicine, 14, 6069-6073. https://doi.org/10.3892/etm.2017.5282
MLA
Jing, Y., Liu, H., Xu, W., Yang, Q."Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis". Experimental and Therapeutic Medicine 14.6 (2017): 6069-6073.
Chicago
Jing, Y., Liu, H., Xu, W., Yang, Q."Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6069-6073. https://doi.org/10.3892/etm.2017.5282
Copy and paste a formatted citation
x
Spandidos Publications style
Jing Y, Liu H, Xu W and Yang Q: Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis. Exp Ther Med 14: 6069-6073, 2017.
APA
Jing, Y., Liu, H., Xu, W., & Yang, Q. (2017). Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis. Experimental and Therapeutic Medicine, 14, 6069-6073. https://doi.org/10.3892/etm.2017.5282
MLA
Jing, Y., Liu, H., Xu, W., Yang, Q."Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis". Experimental and Therapeutic Medicine 14.6 (2017): 6069-6073.
Chicago
Jing, Y., Liu, H., Xu, W., Yang, Q."Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6069-6073. https://doi.org/10.3892/etm.2017.5282
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