Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

α‑klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review)

  • Authors:
    • Yang Xu
    • Hao Peng
    • Ben Ke
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Nanchang University School of Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5691-5695
    |
    Published online on: October 11, 2017
       https://doi.org/10.3892/etm.2017.5287
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Normocytic normochromic anemia is a common complication of chronic kidney disease (CKD) and is associated with numerous adverse consequences. Certain symptoms previously attributed to CKD are now known to be a consequence of anemia. Anemia contributes to an increased cardiac output, and the development of left ventricular hypertrophy, angina and congestive heart failure, leading to high morbidity and mortality in patients with CKD. The multifunctional α‑klotho (KL) protein, which is predominantly expressed in the kidneys, is associated with the occurrence of anemia in patients with CKD. The present review presents current evidence on the potential role of α‑KL in renal anemia. Low expression of α‑KL appears to improve anemia in patients with CKD, and has been hypothesized to be a compensatory mechanism to attenuate the effects of anemia in patients with CKD. Further understanding of the role of α‑KL in renal anemia may offer novel insights into the treatment of patients with CKD complicated with anemia.
View Figures

Figure 1

Figure 2

View References

1 

Zadrazil J and Horak P: Pathophysiology of anemia in chronic kidney diseases: A review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 159:197–202. 2015.PubMed/NCBI

2 

Collister D, Ferguson T, Komenda P and Tangri N: The patterns, risk factors and prediction of progression in chronic kidney disease: A narrative review. Semin Nephrol. 36:273–282. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Singh AK, Szczech L, Tang KL, Barnhart H, Sapp S, Wolfson M and Reddan D: CHOIR Investigators: Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 355:2085–2098. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Drüeke TB, Locatelli F, Clyne N, Eckardt KU, Macdougall IC, Tsakiris D, Burger HU and Scherhag A: CREATE Investigators: Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med. 355:2071–2084. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, Feyzi JM, Ivanovich P, Kewalramani R, Levey AS, et al: A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med. 361:2019–2032. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Akasaka-Manya K, Manya H and Endo T: Function and change with aging of alpha-klotho in the kidney. Vitam and horm. 101:239–256. 2016. View Article : Google Scholar

7 

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, et al: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 390:45–51. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Kurosu H and Kuro OM: The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol. 299:72–78. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Ide N, Olauson H, Sato T, Densmore MJ, Wang H, Hanai JI, Larsson TE and Lanske B: In vivo evidence for a limited role of proximal tubular klotho in renal phosphate handling. Kidney Int. 99:348–362:. 2016. View Article : Google Scholar

10 

Hu MC, Shi M, Zhang J, Addo T, Cho HJ, Barker SL, Ravikumar P, Gillings N, Bian A, Sidhu SS, et al: Renal production, uptake and handling of circulating αKlotho. J Am Soc Nephrol. 27:79–90. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Zhou L, Mo H, Miao J, Zhou D, Tan RJ, Hou FF and Liu Y: Klotho ameliorates kidney injury and fibrosis and normalizes blood pressure by targeting the renin-angiotensin system. Am J Pathol. 185:3211–3223. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Kadoya H, Satoh M, Haruna Y, Sasaki T and Kashihara N: Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice. Clin Exp Nephrol. 20:671–678. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Xie J, Yoon J, An SW, Kuro-o M and Huang CL: Soluble klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate. J Am Soc Nephrol. 26:1150–1160. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Milovanov YS, Mukhin NA, Kozlovskaya LV, Milovanova SY and Markina MM: Impact of anemia correction on the production of the circulating morphogenetic protein alpha-Klotho in patients with stages 3B-4 chronic kidney disease: A new direction of cardionephroprotection. Ter Arkh. 88:21–25. 2016.(In Russian; Abstract available in Russian from the publisher). View Article : Google Scholar : PubMed/NCBI

15 

Wang Y and Sun Z: Current understanding of klotho. Ageing Res Rev. 8:43–51. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Xu Y and Sun Z: Molecular basis of Klotho: from gene to function in aging. Endocr Rev. 36:174–193. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Chen CD, Podvin S, Gillespie E, Leeman SE and Abraham CR: Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci USA. 104:pp. 19796–19801. 2007, View Article : Google Scholar : PubMed/NCBI

18 

Olauson H, Lindberg K, Amin R, Jia T, Wernerson A, Andersson G and Larsson TE: Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism. J Am Soc Nephrol. 23:1641–1651. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Martin A, David V and Quarles LD: Regulation and function of the FGF23/klotho endocrine pathways. Physiol Rev. 92:131–155. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Liu Y and Zhang Q: Periodontitis aggravated pancreatic beta-cell dysfunction in diabetic mice through interleukin-12 regulation on Klotho. J Diabetes Investig. 7:303–311. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Chen J, Lin Y and Sun Z: Deficiency in the anti-aging gene Klotho promotes aortic valve fibrosis through AMPKα-mediated activation of RUNX2. Aging cell. 15:853–860:. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Madathil Vadakke S, Coe LM, Casu C and Sitara D: Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis. Am J Pathol. 184:827–841. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Solak Y, Cetiner M, Siriopol D, Tarim K, Afsar B, Covic A and Kanbay M: Novel masters of erythropoiesis: hypoxia inducible factors and recent advances in anemia of renal disease. Blood purif. 42:160–167. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Buendia P, Carracedo J, Soriano S, Madueño JA, Ortiz A, Martín-Malo A, Aljama P and Ramírez R: Klotho prevents NFκB translocation and protects endothelial cell from senescence induced by uremia. J Gerontol A Biol Sci Med Sci. 70:1198–1209. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Kempe DS, Ackermann TF, Fischer SS, Koka S, Boini KM, Mahmud H, Föller M, Rosenblatt KP, Kuro-O M and Lang F: Accelerated suicidal erythrocyte death in Klotho-deficient mice. Pflugers Arch. 458:503–512. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Pasricha SR, Drakesmith H, Black J, Hipgrave D and Biggs BA: Control of iron deficiency anemia in low- and middle-income countries. Blood. 121:2607–2617. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Stancu S, Stanciu A, Zugravu A, Bârsan L, Dumitru D, Lipan M and Mircescu G: Bone marrow iron, iron indices and the response to intravenous iron in patients with non-dialysis-dependent CKD. Am J Kidney Dis. 55:639–647. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Barsan L, Stanciu A, Stancu S, Căpuşă C, Brătescu L, Mandache E, Radu E and Mircescu G: Bone marrow iron distribution, hepcidin and ferroportin expression in renal anemia. Hematology. 20:543–552. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Milovanova L, Iu Milovanov S, Kozlovskaia LV and Mukhin NA: Significance of the morphogenetic proteins FGF-23 and Klotho as predictors of prognosis of chronic kidney disease. Ter Arkh. 86:36–44. 2014.(In Russian). PubMed/NCBI

30 

Saito K, Ishizaka N, Mitani H, Ohno M and Nagai R: Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat. FEBS Lett. 551:58–62. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Taylor M, Qu A, Anderson ER, Matsubara T, Martin A, Gonzalez FJ and Shah YM: Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 140:2044–2055. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Goncalves JG, de Braganca AC, Canale D, Shimizu MH, Sanches TR, Moysés RM, Andrade L, Seguro AC and Volpini RA: Vitamin D deficiency aggravates chronic kidney disease progression after ischemic acute kidney injury. PLoS One. 9:e1072282014. View Article : Google Scholar : PubMed/NCBI

33 

Goldsmith DJ: Pro: Should we correct vitamin D deficiency/insufficiency in chronic kidney disease patients with inactive forms of vitamin D or just treat them with active vitamin D forms? Nephrol Dial Transplant. 31:698–705. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Agarwal R and Georgianos PI: Con: Nutritional vitamin D replacement in chronic kidney disease and end-stage renal disease. Nephrol Dial Transplant. 31:706–713. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Monlezun DJ, Camargo CA Jr, Mullen JT and Quraishi SA: Vitamin d status and the risk of anemia in community-dwelling adults: Results from the national health and nutrition examination survey 2001–2006. Medicine (Baltimore). 94:e17992015. View Article : Google Scholar : PubMed/NCBI

36 

Suh YJ, Lee JE, Lee DH, Yi HG, Lee MH, Kim CS, Nah JW and Kim SK: Prevalence and relationships of iron deficiency anemia with blood cadmium and vitamin D levels in Korean women. J Korean Med Sci. 31:25–32. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Forster RE, Jurutka PW, Hsieh JC, Haussler CA, Lowmiller CL, Kaneko I, Haussler MR and Whitfield Kerr G: Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells. Biochem Biophys Res Commun. 414:557–562. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Lips P: Vitamin D physiology. Prog Biophys Mol Biol. 92:4–8. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Kuro-o M: Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. Nat Rev Nephrol. 9:650–660. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Alesutan I, Feger M, Pakladok T, Mia S, Ahmed MS, Voelkl J and Lang F: 25-Hydroxyvitamin D3 1-α-hydroxylase-dependent stimulation of renal klotho expression by spironolactone. Kidney Blood Press Res. 37:475–487. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Takenaka T, Inoue T, Ohno Y, Miyazaki T, Nishiyama A, Ishii N and Suzuki H: Calcitriol supplementation improves endothelium-dependent vasodilation in rat hypertensive renal injury. Kidney Blood Press Res. 39:17–27. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Leibrock CB, Voelkl J, Kuro-O M, Lang F and Lang UE: 1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice. Sci Rep. 6:248792016. View Article : Google Scholar : PubMed/NCBI

43 

Ichii O, Nakamura T, Irie T, Kouguchi H, Nakamura D, Nakamura S, Sato S, Yokoyama K, Horino T, Sunden Y, et al: Female cotton rats (Sigmodon hispidus) develop chronic anemia with renal inflammation and cystic changes. Histochem Cell Biol. 146:351–362. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Chung ACK and Lan HY: Chemokines in renal injury. J Am Soc Nephrol. 22:802–809. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Mack M and Yanagita M: Origin of myofibroblasts and cellular events triggering fibrosis. Kidney Int. 87:297–307. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Wang CY and Babitt JL: Hepcidin regulation in the anemia of inflammation. Curr Opin Hematol. 23:189–197. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, et al: Suppression of aging in mice by the hormone Klotho. Science. 309:1829–1833. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Wada J and Makino H: Inflammation and the pathogenesis of diabetic nephropathy. Clin Sci (Lond). 124:139–152. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Zhao Y, Banerjee S, Dey N, LeJeune WS, Sarkar PS, Brobey R, Rosenblatt KP, Tilton RG and Choudhary S: Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation. Diabetes. 60:1907–1916. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Wu C, Lv C, Chen F, Ma X, Shao Y and Wang Q: The function of miR-199a-5p/Klotho regulating TLR4/NF-kappaB p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. Mol Cell Endocrinol. 417:84–93. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Shao Y, Sha M, Chen L, Li D, Lu J and Xia S: HMGB1/TLR4 signaling induces an inflammatory response following high-pressure renal pelvic perfusion in a porcine model. Am J Physiol Renal Physiol. 311:F915–F925. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Yang K, Nie L, Huang Y, Zhang J, Xiao T, Guan X and Zhao J: Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein. Toxicol Lett. 215:77–83. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Peng H and Ke B: α‑klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review). Exp Ther Med 14: 5691-5695, 2017.
APA
Xu, Y., Peng, H., & Ke, B. (2017). α‑klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review). Experimental and Therapeutic Medicine, 14, 5691-5695. https://doi.org/10.3892/etm.2017.5287
MLA
Xu, Y., Peng, H., Ke, B."α‑klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review)". Experimental and Therapeutic Medicine 14.6 (2017): 5691-5695.
Chicago
Xu, Y., Peng, H., Ke, B."α‑klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review)". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5691-5695. https://doi.org/10.3892/etm.2017.5287
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Peng H and Ke B: α‑klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review). Exp Ther Med 14: 5691-5695, 2017.
APA
Xu, Y., Peng, H., & Ke, B. (2017). α‑klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review). Experimental and Therapeutic Medicine, 14, 5691-5695. https://doi.org/10.3892/etm.2017.5287
MLA
Xu, Y., Peng, H., Ke, B."α‑klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review)". Experimental and Therapeutic Medicine 14.6 (2017): 5691-5695.
Chicago
Xu, Y., Peng, H., Ke, B."α‑klotho and anemia in patients with chronic kidney disease patients: A new perspective (Review)". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5691-5695. https://doi.org/10.3892/etm.2017.5287
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team