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Interferon‑α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh‑7 cells transfected with hepatitis B virus X gene‑expressing lentivirus

  • Authors:
    • Qian Yang
    • Xiao‑Peng Li
    • Yuan‑Bin Zhong
    • Tian‑Xin Xiang
    • Lun‑Li Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5924-5930
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    Published online on: October 11, 2017
       https://doi.org/10.3892/etm.2017.5288
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Abstract

Hepatitis B virus (HBV) X protein (HBx) serves an important role in HBV infection and the development of HBV‑related liver cancer. Interferon‑α (IFN‑α) is used to treat patients with HBV; however, the role of IFN‑α in the development of HBV‑related liver cancer remains unclear. The present study established a new HBV‑related liver cancer model (Huh‑7‑HBx) by transfecting the hepatoma cell line Huh‑7, with HBx‑expressing lentivirus. Following IFN‑α treatment, cell viability, migration and invasion, as well as the expression of antiviral proteins in Huh‑7‑HBx, were subsequently determined. The results demonstrated that HBx‑expressing lentivirus had no significant effect on cell viability but promoted the migration and invasion of Huh‑7 cells. The expression of the antiviral genes IFN α and β receptor subunit 1 (IFNAR1), IFNAR2, IFN‑stimulated gene factor 3, double‑stranded RNA‑activated protein kinase and ribonuclease L, was also increased. Following treatment of Huh‑7‑HBx cells with IFN‑α, the expression of antiviral genes was increased at the level of transcription and translation, whereas cell migration and invasion was decreased. The present study suggests that IFN‑α may attenuate the development of HBV‑related liver cancer by reducing cell migration and invasion and promoting the expression of antiviral proteins.
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View References

1 

Lavanchy D: Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 11:97–107. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Liaw YF and Chu CM: Hepatitis B virus infection. Lancet. 373:582–592. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Hooshyar A, Habibzadeh S, Ghasemi N, Yazdanbod A, Sohrabi S, Maleki N and Amani F: Females have a lower liver histopathological score in HBeAg-negative chronic hepatitis B than males. Arch Clin Infect Dis. 8:e179722013. View Article : Google Scholar

4 

Yang N and Bertoletti A: Advances in therapeutics for chronic hepatitis B. Hepatol Int. 10:277–285. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Chen J, Zhao J, Chen L, Dong N, Ying Z, Cai Z, Ji D, Zhang Y, Dong L, Li Y, et al: STAT1 modification improves therapeutic effects of interferons on lung cancer cells. J Transl Med. 13:2932015. View Article : Google Scholar : PubMed/NCBI

6 

Gerber SA, Yatsula B, Maier CL, Sadler TJ, Whittaker LW and Pober JS: Interferon-gamma induces prolyl hydroxylase (PHD)3 through a STAT1-dependent mechanism in human endothelial cells. Arterioscler Thromb Vasc Biol. 29:1363–1369. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Rehermann B and Bertoletti A: Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections. Hepatology. 61:712–721. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Bowick GC, Airo AM and Bente DA: Expression of interferon-induced antiviral genes is delayed in a STAT1 knockout mouse model of Crimean-Congo hemorrhagic fever. Virol J. 9:1222012. View Article : Google Scholar : PubMed/NCBI

9 

von Marschall Z, Scholz A, Cramer T, Schäfer G, Schirner M, Oberg K, Wiedenmann B, Höcker M and Rosewicz S: Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis. J Natl Cancer Inst. 95:437–448. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Fazio N and Oberg K: Prospective, randomized, multicenter trial on the antiproliferative effect of lanreotide, interferon alfa and their combination for therapy of metastatic neuroendocrine gastroenteropancreatic tumors. J Clin Oncol. 22:573–575. 2004. View Article : Google Scholar : PubMed/NCBI

11 

De Palma M, Mazzieri R, Politi LS, Pucci F, Zonari E, Sitia G, Mazzoleni S, Moi D, Venneri MA, Indraccolo S, et al: Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell. 14:299–311. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Kim JY, Song EH, Lee HJ, Oh YK, Choi KH, Yu DY, Park SI, Seong JK and Kim WH: HBx-induced hepatic steatosis and apoptosis are regulated by TNFR1- and NF-kappaB-dependent pathways. J Mol Biol. 397:917–931. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Wang HY, Yang SL, Liang HF and Li CH: HBx protein promotes oval cell proliferation by up-regulation of cyclin D1 via activation of the MEK/ERK and PI3K/Akt pathways. Int J Mol Sci. 15:3507–3518. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Murakami S: Hepatitis B virus X protein: A multifunctional viral regulator. J Gastroenterol. 36:651–660. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Kim CM, Koike K, Saito I, Miyamura T and Jay G: HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature. 351:317–320. 1991. View Article : Google Scholar : PubMed/NCBI

16 

Lara-Pezzi E, Gomez-Gaviro MV, Galvez BG, Mira E, Iñiguez MA, Fresno M, Martínez AC, Arroyo AG and López-Cabrera M: The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. J Clin Invest. 110:1831–1838. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Tanaka Y, Kanai F, Kawakami T, Tateishi K, Ijichi H, Kawabe T, Arakawa Y, Kawakami T, Nishimura T, Shirakata Y, et al: Interaction of the hepatitis B virus X protein (HBx) with heat shock protein 60 enhances HBx-mediated apoptosis. Biochem Biophys Res Commun. 318:461–469. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Zhang X, Liu S, Hu T, Liu S, He Y and Sun S: Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression. Hepatology. 50:490–499. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Lizee G, Aerts JL, Gonzales MI, Chinnasamy N, Morgan RA and Topalian SL: Real-time quantitative reverse transcriptase-polymerase chain reaction as a method for determining lentiviral vector titers and measuring transgene expression. Hum Gene Ther. 14:497–507. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Frodsham AJ, Zhang L, Dumpis U, Taib NA, Best S, Durham A, Hennig BJ, Hellier S, Knapp S, Wright M, et al: Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. Proc Natl Acad Sci USA. 103:pp. 9148–9153. 2006, View Article : Google Scholar : PubMed/NCBI

22 

Zhou J, Smith DK, Lu L, Poon VK, Ng F, Chen DQ, Huang JD, Yuen KY, Cao KY and Zheng BJ: A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection. J Viral Hepat. 16:45–52. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Han Q, Zhang C, Zhang J and Tian Z: Involvement of activation of PKR in HBx-siRNA-mediated innate immune effects on HBV inhibition. PLoS One. 6:e279312011. View Article : Google Scholar : PubMed/NCBI

24 

Park IH, Kwon YC, Ryu WS and Ahn BY: Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L. Antiviral Res. 104:118–127. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Q, Wang Y, Wei L, Jiang D, Wang JH, Rao HY, Zhu L, Chen HS, Fei R and Cong X: Role of ISGF3 in modulating the anti-hepatitis B virus activity of interferon-alpha in vitro. J Gastroenterol Hepatol. 23:1747–1761. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Perz JF, Armstrong GL, Farrington LA, Hutin YJ and Bell BP: The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol. 45:529–538. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Kong J, Kong F, Gao J, Zhang Q, Dong S, Gu F, Ke S, Pan B, Shen Q, Sun H, et al: YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 13:72014. View Article : Google Scholar : PubMed/NCBI

28 

Terrault NA, Bzowej NH, Chang KM, Hwang JP, Jonas MM and Murad MH: American Association for the Study of Liver Diseases: AASLD guidelines for treatment of chronic hepatitis B. Hepatology. 63:261–283. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Yuen MF, Ahn SH, Chen DS, Chen PJ, Dusheiko GM, Hou JL, Maddrey WC, Mizokami M, Seto WK, Zoulim F, et al: Chronic hepatitis b virus infection: Disease revisit and management recommendations. J Clin Gastroenterol. 50:286–294. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Belloni L, Allweiss L, Guerrieri F, Pediconi N, Volz T, Pollicino T, Petersen J, Raimondo G, Dandri M and Levrero M: IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J Clin Invest. 122:529–537. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Lai CL and Yuen MF: Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy. Hepatology. 57:399–408. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Robek MD, Boyd BS and Chisari FV: Lambda interferon inhibits hepatitis B and C virus replication. J Virol. 79:3851–3854. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Piratvisuth T: Reviews for APASL guidelines: Immunomodulator therapy of chronic hepatitis B. Hepatol Int. 2:140–146. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Sprengers D and Janssen HL: Immunomodulatory therapy for chronic hepatitis B virus infection. Fundam Clin Pharmacol. 19:17–26. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Uzé G, Di Marco S, Mouchel-Vielh E, Monneron D, Bandu MT, Horisberger MA, Dorques A, Lutfalla G and Mogensen KE: Domains of interaction between alpha interferon and its receptor components. J Mol Biol. 243:245–257. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Peltekian C, Gordien E, Garreau F, Meas-Yedid V, Soussan P, Willams V, Chaix ML, Olivo-Marin JC, Bréchot C and Kremsdorf D: Human MxA protein participates to the interferon-related inhibition of hepatitis B virus replication in female transgenic mice. J Hepatol. 43:965–972. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Su L and David M: Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol. J Biol Chem. 275:12661–12666. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Rani MR, Leaman DW, Han Y, Leung S, Croze E, Fish EN, Wolfman A and Ransohoff RM: Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase. J Biol Chem. 274:32507–32511. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Ward SV and Samuel CE: The PKR kinase promoter binds both Sp1 and Sp3, but only Sp3 functions as part of the interferon-inducible complex with ISGF-3 proteins. Virology. 313:553–566. 2003. View Article : Google Scholar : PubMed/NCBI

40 

George CX, Das S and Samuel CE: Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5′-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon. Virology. 380:338–343. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Goh KC, Haque SJ and Williams BR: p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J. 18:5601–5608. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Yang X and Chan C: Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2. Cell Res. 19:469–486. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Chai Y, Huang HL, Hu DJ, Luo X, Tao QS, Zhang XL and Zhang SQ: IL-29 and IFN-α regulate the expression of MxA, 2′,5′-OAS and PKR genes in association with the activation of Raf-MEK-ERK and PI3K-AKT signal pathways in HepG2.2.15 cells. Mol Biol Rep. 38:139–143. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Guan SH, Lu M, Grünewald P, Roggendorf M, Gerken G and Schlaak JF: Interferon-alpha response in chronic hepatitis B-transfected HepG2.2.15 cells is partially restored by lamivudine treatment. World J Gastroenterol. 13:228–235. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Mathews JD, McCaw CT, McVernon J, McBryde ES and McCaw JM: A biological model for influenza transmission: Pandemic planning implications of asymptomatic infection and immunity. PLoS One. 2:e12202007. View Article : Google Scholar : PubMed/NCBI

46 

Ren S, Yu H, Zhang H, Liu Y, Huang Y, Ma L, Wei L, Wu H and Chen XY: Polymorphisms of interferon-inducible genes OAS associated with interferon-α treatment response in chronic HBV infection. Antiviral Res. 89:232–237. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang Q, Li XP, Zhong YB, Xiang TX and Zhang LL: Interferon‑α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh‑7 cells transfected with hepatitis B virus X gene‑expressing lentivirus. Exp Ther Med 14: 5924-5930, 2017.
APA
Yang, Q., Li, X., Zhong, Y., Xiang, T., & Zhang, L. (2017). Interferon‑α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh‑7 cells transfected with hepatitis B virus X gene‑expressing lentivirus. Experimental and Therapeutic Medicine, 14, 5924-5930. https://doi.org/10.3892/etm.2017.5288
MLA
Yang, Q., Li, X., Zhong, Y., Xiang, T., Zhang, L."Interferon‑α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh‑7 cells transfected with hepatitis B virus X gene‑expressing lentivirus". Experimental and Therapeutic Medicine 14.6 (2017): 5924-5930.
Chicago
Yang, Q., Li, X., Zhong, Y., Xiang, T., Zhang, L."Interferon‑α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh‑7 cells transfected with hepatitis B virus X gene‑expressing lentivirus". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5924-5930. https://doi.org/10.3892/etm.2017.5288
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Q, Li XP, Zhong YB, Xiang TX and Zhang LL: Interferon‑α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh‑7 cells transfected with hepatitis B virus X gene‑expressing lentivirus. Exp Ther Med 14: 5924-5930, 2017.
APA
Yang, Q., Li, X., Zhong, Y., Xiang, T., & Zhang, L. (2017). Interferon‑α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh‑7 cells transfected with hepatitis B virus X gene‑expressing lentivirus. Experimental and Therapeutic Medicine, 14, 5924-5930. https://doi.org/10.3892/etm.2017.5288
MLA
Yang, Q., Li, X., Zhong, Y., Xiang, T., Zhang, L."Interferon‑α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh‑7 cells transfected with hepatitis B virus X gene‑expressing lentivirus". Experimental and Therapeutic Medicine 14.6 (2017): 5924-5930.
Chicago
Yang, Q., Li, X., Zhong, Y., Xiang, T., Zhang, L."Interferon‑α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh‑7 cells transfected with hepatitis B virus X gene‑expressing lentivirus". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5924-5930. https://doi.org/10.3892/etm.2017.5288
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