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Apelin as a novel drug for treating preeclampsia

  • Authors:
    • Chengshu Wang
    • Xiaoli Liu
    • Desheng Kong
    • Xijing Qin
    • Yanqing Li
    • Xu Teng
    • Xianghua Huang
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050005, P.R. China, Department of Gynaecology, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei 050011, P.R. China, Hebei Key Laboratory of Laboratory Animal Science, Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5917-5923
    |
    Published online on: October 13, 2017
       https://doi.org/10.3892/etm.2017.5304
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Abstract

Preeclampsia is a pregnancy‑specific disorder of new‑onset hypertension and proteinuria after 20 weeks' gestation, often resulting in poor outcome. Previous studies demonstrated that apelin is an endogenous active peptide with visodilation and anti‑oxidative stress capabilities. The present study investigated the effects of apelin in a rat model of preeclampsia induced by reduced uterine perfusion pressure (RUPP). Rats with RUPP displayed hypertension and poor pregnancy outcomes, such as decreased fetal and placental weight. Of note, apelin treatment significantly ameliorated the symptoms of preeclampsia, improved the impaired endothelial nitric oxide synthase/nitric oxide signaling and attenuated activation of oxidative stress in RUPP rats. Apelin may be a potential agent for preventing and treating preeclampsia.
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1 

Burton GJ, Jauniaux E and Watson AL: Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: The boyd collection revisited. Am J Obstet Gyneco. 181:718–724. 1999. View Article : Google Scholar

2 

Walker JJ: Pre-eclampsia. Lancet. 356:1260–1265. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Hung TH, Skepper JN and Burton GJ: In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. Am J Pathol. 159:1031–1043. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Redman CW and Sargent IL: Latest advances in understanding preeclampsia. Science. 308:1592–1594. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Duley L: Maternal mortality associated with hypertensive disorders of pregnancy in africa, asia, latin america and the caribbean. Br J Obstet Gynaecol. 99:547–553. 1992. View Article : Google Scholar : PubMed/NCBI

6 

Oyston CJ, Stanley JL and Baker PN: Potential targets for the treatment of preeclampsia. Expert Opin Ther Targets. 19:1517–1530. 2015. View Article : Google Scholar : PubMed/NCBI

7 

O'Carroll AM, Lolait SJ, Harris LE and Pope GR: The apelin receptor APJ: Journey from an orphan to a multifaceted regulator of homeostasis. J Endocrinol. 219:R13–R35. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, Osmond DH, George SR and O'Dowd BF: Characterization of apelin, the ligand for the APJ receptor. J Neurochem. 74:34–41. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR and O'Dowd BF: Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology. 146:231–236. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Chun HJ, Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R, Zheng L, Leeper NJ, Pearl NE, Patterson AJ, et al: Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest. 118:3343–3354. 2008.PubMed/NCBI

11 

Japp AG, Cruden NL, Barnes G, van Gemeren N, Mathews J, Adamson J, Johnston NR, Denvir MA, Megson IL, Flapan AD, et al: Acute cardiovascular cffects of apelin in humans: potential role in patients with chronic heart failure. Circulation. 121:1818–1827. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, Pikkarainen S, Piuhola J, Rysä J, Toth M, et al: Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res. 91:434–440. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Kidoya H and Takakura N: Biology of the apelin-APJ axis in vascular formation. J Biochem. 152:125–131. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Leeper NJ, Tedesco MM, Kojima Y, Schultz GM, Kundu RK, Ashley EA, Tsao PS, Dalman RL and Quertermous T: Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. Am J Physiol Heart Circ Physiol. 296:H1329–H1335. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, Lawrie KW, Hervieu G, Riley G, Bolaky JE, et al: Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 84:1162–1172. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Bortoff KD, Qiu C, Runyon S, Williams MA and Maitra R: Decreased maternal plasma apelin concentrations in preeclampsia. Hypertens Pregnancy. 31:398–404. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Inuzuka H, Nishizawa H, Inagaki A, Suzuki M, Ota S, Miyamura H, Miyazaki J, Sekiya T, Kurahashi H and Udagawa Y: Decreased expression of apelin in placentas from severe pre-eclampsia patients. Hypertens Pregnancy. 32:410–421. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Caudell DL, Shi S, McGee C, Pirro N, Gallagher PE, Taylor RN, et al: Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies. Am J Physiol Endocrinol Metab. 309:E852–E860. 2015.PubMed/NCBI

19 

Furuya M, Okuda M, Usui H, Takenouchi T, Kami D, Nozawa A, Shozu M, Umezawa A, Takahashi T and Aoki I: Expression of angiotensin II receptor-like 1 in the placentas of pregnancy-induced hypertension. Int J Gynecol Pathol. 31:227–235. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Cobellis L, De Falco M, Mastrogiacomo A, Giraldi D, Dattilo D, Scaffa C, Colacurci N and De Luca A: Modulation of apelin and APJ receptor in normal and preeclampsia-complicated placentas. Histol Histopathol. 22:1–8. 2007.PubMed/NCBI

21 

Kucur M, Tuten A, Oncul M, Acikgoz AS, Yuksel MA, Imamoglu M, Balci Ekmekci O, Yilmaz N and Madazli R: Maternal serum apelin and YKL-40 levels in early and late-onset pre-eclampsia. Hypertens Pregnancy. 33:467–475. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Alexander BT, Kassab SE, Miller MT, Abram SR, Reckelhoff JF, Bennett WA and Granger JP: Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide. Hypertension. 37:1191–1195. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Granger JP, LaMarca BB, Cockrell K, Sedeek M, Balzi C, Chandler D and Bennett W: Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia. Methods Mol Med. 122:383–392. 2006.PubMed/NCBI

24 

Gilbert JS, Ryan MJ, LaMarca BB, Sedeek M, Murphy SR and Granger JP: Pathophysiology of hypertension during preeclampsia: Linking placental ischemia with endothelial dysfunction. Am J Physiol Heart Circ Physiol. 294:H541–H550. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Spradley FT, Tan AY, Joo WS, Daniels G, Kussie P, Karumanchi SA and Granger JP: Placental growth factor administration abolishes placental ischemia-induced hypertension. Hypertension. 67:740–747. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Ashworth JR, Warren AY, Johnson IR and Baker PN: Plasma from pre-eclamptic women and functional change in myometrial resistance arteries. Br J Obstet Gynaecol. 105:459–461. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Hayman R, Warren A, Johnson I and Baker P: Inducible change in the behavior of resistance arteries from circulating factor in preeclampsia: An effect specific to myometrial vessels from pregnant women. Am J Obstet. Gynecol. 184:420–426. 2001. View Article : Google Scholar

28 

Lekontseva O, Jiang Y, Schleppe C and Davidge ST: Altered neuronal nitric oxide synthase in the aging vascular system: Implications for estrogens therapy. Endocrinology. 153:3940–3948. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Amaral LM, Pinheiro LC, Guimaraes DA, Palei AC, Sertório JT, Portella RL and Tanus-Santos JE: Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental pre-eclampsia. J Cell Mol Med. 17:1300–1307. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Eckman DM, Gupta R, Rosenfeld CR, Morgan TM, Charles SM, Mertz H and Moore LG: Pregnancy increases myometrial artery myogenic tone via NOS- or COX-independent mechanisms. Am J Physiol Regul Integr Comp Physiol. 303:R368–R375. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Kulandavelu S, Whiteley KJ, Bainbridge SA, Qu D and Adamson SL: Endothelial NO synthase augments fetoplacental blood flow, placental vascularization, and fetal growth in mice. Hypertension. 61:259–266. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Vadillo-Ortega F, Perichart-Perera O, Espino S, Avila-Vergara MA, Ibarra I, Ahued R, Godines M, Parry S, Macones G and Strauss JF: Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: Randomised controlled trial. BMJ. 342:d29012011. View Article : Google Scholar : PubMed/NCBI

33 

Jia YX, Lu ZF, Zhang J, Pan CS, Yang JH, Zhao J, Yu F, Duan XH, Tang CS and Qi YF: Apelin activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas. Peptides. 28:2023–2029. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Busch R, Strohbach A, Pennewitz M, Lorenz F, Bahls M, Busch MC and Felix SB: Regulation of the endothelial apelin/APJ system by hemodynamic fluid flow. Cell Signal. 27:1286–1296. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Siddiqui IA, Jaleel A, Tamimi W and Al Kadri HM: Role of oxidative stress in the pathogenesis of preeclampsia. Arch Gynecol Obstet. 282:469–474. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Wu F, Tian FJ and Lin Y: Oxidative stress in placenta: Health and diseases. Biomed Res Int. 2015:2932712015. View Article : Google Scholar : PubMed/NCBI

37 

Than A, Zhang X, Leow MK, Poh CL, Chong SK and Chen P: Apelin attenuates oxidative stress in human adipocytes. J Biol Chem. 289:3763–3774. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Pisarenko O, Shulzhenko V, Studneva I, Pelogeykina Y, Timoshin A, Anesia R, Valet P, Parini A and Kunduzova O: Structural apelin analogues: Mitochondrial ROS inhibition and cardiometabolic protection in myocardial ischaemia reperfusion injury. Br J Pharmacol. 172:2933–2945. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Liu X, Kong D, Qin X, Li Y, Teng X and Huang X: Apelin as a novel drug for treating preeclampsia. Exp Ther Med 14: 5917-5923, 2017.
APA
Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., & Huang, X. (2017). Apelin as a novel drug for treating preeclampsia. Experimental and Therapeutic Medicine, 14, 5917-5923. https://doi.org/10.3892/etm.2017.5304
MLA
Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., Huang, X."Apelin as a novel drug for treating preeclampsia". Experimental and Therapeutic Medicine 14.6 (2017): 5917-5923.
Chicago
Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., Huang, X."Apelin as a novel drug for treating preeclampsia". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5917-5923. https://doi.org/10.3892/etm.2017.5304
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Liu X, Kong D, Qin X, Li Y, Teng X and Huang X: Apelin as a novel drug for treating preeclampsia. Exp Ther Med 14: 5917-5923, 2017.
APA
Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., & Huang, X. (2017). Apelin as a novel drug for treating preeclampsia. Experimental and Therapeutic Medicine, 14, 5917-5923. https://doi.org/10.3892/etm.2017.5304
MLA
Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., Huang, X."Apelin as a novel drug for treating preeclampsia". Experimental and Therapeutic Medicine 14.6 (2017): 5917-5923.
Chicago
Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., Huang, X."Apelin as a novel drug for treating preeclampsia". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5917-5923. https://doi.org/10.3892/etm.2017.5304
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